[article] 
inJournal of Neurodevelopmental Disorders > 3-2 (June 2011) . - p.144-51

Titre :	Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders
Type de document :	Texte imprimé et/ou numérique
Auteurs :	F. J. SYMONS, Auteur ; J. J. WOLFF, Auteur ; L. S. STONE, Auteur ; T. K. LIM, Auteur ; James W. BODFISH, Auteur
Article en page(s) :	p.144-51
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; alpha-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i.e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p < 0.01) between the SIB and control group (SIB > control). Within-group analyses showed significant differences (p < 0.05) in levels of salivary alpha-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB + SMD > SIB). Salivary alpha-amylase was significantly correlated with frequency of stereotypy among the SIB group (r = 0.36, p < 0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.
En ligne :	http://dx.doi.org/10.1007/s11689-011-9080-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

[article] Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders [Texte imprimé et/ou numérique] / F. J. SYMONS, Auteur ; J. J. WOLFF, Auteur ; L. S. STONE, Auteur ; T. K. LIM, Auteur ; James W. BODFISH, Auteur . - p.144-51.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 3-2 (June 2011) . - p.144-51

Index. décimale :	PER Périodiques
Résumé :	Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; alpha-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i.e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p < 0.01) between the SIB and control group (SIB > control). Within-group analyses showed significant differences (p < 0.05) in levels of salivary alpha-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB + SMD > SIB). Salivary alpha-amylase was significantly correlated with frequency of stereotypy among the SIB group (r = 0.36, p < 0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.
En ligne :	http://dx.doi.org/10.1007/s11689-011-9080-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343