[article]
| Titre : |
Neurophysiological hyperresponsivity to sensory input in autism spectrum disorders |
| Type de document : |
texte imprimé |
| Auteurs : |
Y. TAKARAE, Auteur ; S. R. SABLICH, Auteur ; S. P. WHITE, Auteur ; J. A. SWEENEY, Auteur |
| Article en page(s) : |
p.29 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Contrast sensitivity Heterogeneity Individual differences Sensory hypersensitivity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Atypical sensory processing is a common clinical observation in autism spectrum disorder (ASD). Neural hyperexcitability has been suggested as the cause for sensory hypersensitivity, a frequently reported clinical observation in ASD. We examined visual evoked responses to parametric increases in stimulus contrast in order to model neural responsivity of sensory systems in ASD. METHODS: Thirteen high-functioning individuals with ASD and 12 typically developing (TD) individuals completed a steady-state visual evoked potential study. Stimuli were vertical circular gratings oscillating at 3.76 Hz at varying contrasts (5, 10, 20,..., 90 % contrast, 10 levels). The average spectral power at the stimulus oscillation frequency was calculated for each contrast level. RESULTS: The magnitude of evoked sensory responses increased at a significantly greater rate and resulted in disproportionately elevated activation with higher contrasts in the ASD group. Approximately 45 % of ASD participants had rates of response increases greater than any TD participant. This alteration was highly associated with parental reports of these participants' sensory difficulties. CONCLUSIONS: Greater increases in visual responses over contrast manipulation suggest heightened excitability in the sensory cortex in ASD participants. Heightened neural excitability was observed in a substantial portion but not all of the ASD participants. This pattern suggests that individuals with higher excitability may constitute a neurobiologically distinct subgroup requiring individualized treatment interventions. |
| En ligne : |
http://dx.doi.org/10.1186/s11689-016-9162-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 |
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.29
[article] Neurophysiological hyperresponsivity to sensory input in autism spectrum disorders [texte imprimé] / Y. TAKARAE, Auteur ; S. R. SABLICH, Auteur ; S. P. WHITE, Auteur ; J. A. SWEENEY, Auteur . - p.29. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.29
| Mots-clés : |
Autism Contrast sensitivity Heterogeneity Individual differences Sensory hypersensitivity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Atypical sensory processing is a common clinical observation in autism spectrum disorder (ASD). Neural hyperexcitability has been suggested as the cause for sensory hypersensitivity, a frequently reported clinical observation in ASD. We examined visual evoked responses to parametric increases in stimulus contrast in order to model neural responsivity of sensory systems in ASD. METHODS: Thirteen high-functioning individuals with ASD and 12 typically developing (TD) individuals completed a steady-state visual evoked potential study. Stimuli were vertical circular gratings oscillating at 3.76 Hz at varying contrasts (5, 10, 20,..., 90 % contrast, 10 levels). The average spectral power at the stimulus oscillation frequency was calculated for each contrast level. RESULTS: The magnitude of evoked sensory responses increased at a significantly greater rate and resulted in disproportionately elevated activation with higher contrasts in the ASD group. Approximately 45 % of ASD participants had rates of response increases greater than any TD participant. This alteration was highly associated with parental reports of these participants' sensory difficulties. CONCLUSIONS: Greater increases in visual responses over contrast manipulation suggest heightened excitability in the sensory cortex in ASD participants. Heightened neural excitability was observed in a substantial portion but not all of the ASD participants. This pattern suggests that individuals with higher excitability may constitute a neurobiologically distinct subgroup requiring individualized treatment interventions. |
| En ligne : |
http://dx.doi.org/10.1186/s11689-016-9162-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 |
|  |
Neurophysiological hyperresponsivity to sensory input in autism spectrum disorders in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)
