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Contribution of chromosomal abnormalities at 10q and 22q to autism / Nagwa A. MEGUID in Research in Autism Spectrum Disorders, 50 (June 2018)

Titre :	Contribution of chromosomal abnormalities at 10q and 22q to autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Nagwa A. MEGUID, Auteur ; Maha M. EID, Auteur ; Amal M. MOHAMED, Auteur ; Heba GHANOUM, Auteur ; Nivine A. HELMY, Auteur ; Ola M. EID, Auteur
Année de publication :	2018
Article en page(s) :	p.43-50
Langues :	Anglais (eng)
Mots-clés :	Autism Chromosomal abnormalities Chromosome 10q Chromosome 22q
Index. décimale :	PER Périodiques
Résumé :	Autism’s etiology is heterogeneous. It derives generically from a complex of interactions between genetic, epigenetic and environmental factors. Chromosomal rearrangements at almost all chromosomes have been reported among individuals with autism spectrum disorders (ASD). In this report, we represent three autistic patients with chromosomal abnormalities at 10q and 22q with an interesting case of 10q duplication rather than deletion. This report explores the contribution of the affected genomic regions to ASD. It may contribute to the field of research categorizing candidate loci for ASD, which would be useful in genotype– phenotype analyses for ASD.
En ligne :	https://doi.org/10.1016/j.rasd.2018.03.003
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