[article] 
inDevelopment and Psychopathology > 31-2 (May 2019) . - p.443-456

Titre :	Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Eric L. THIBODEAU, Auteur ; Katherine E. MASYN, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur
Article en page(s) :	p.443-456
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing “well-adjusted,” “externalizing,” “internalizing,” and “socially dominant” groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p < .0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p = .004), adjusting for sex, age, and covariate interaction effects.
En ligne :	http://dx.doi.org/10.1017/S0954579419000014
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

[article] Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model [Texte imprimé et/ou numérique] / Eric L. THIBODEAU, Auteur ; Katherine E. MASYN, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur . - p.443-456.
Langues : Anglais (eng)
in Development and Psychopathology > 31-2 (May 2019) . - p.443-456

Index. décimale :	PER Périodiques
Résumé :	This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing “well-adjusted,” “externalizing,” “internalizing,” and “socially dominant” groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p < .0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p = .004), adjusting for sex, age, and covariate interaction effects.
En ligne :	http://dx.doi.org/10.1017/S0954579419000014
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393