Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children / Valeska STONAWSKI in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.419-431 Titre : Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children Type de document : Texte imprimé et/ou numérique Auteurs : Valeska STONAWSKI, Auteur ; Stefan FREY, Auteur ; Yulia GOLUB, Auteur ; Nicolas ROHLEDER, Auteur ; Jennifer KRIEBEL, Auteur ; Tamme W. GOECKE, Auteur ; Peter A. FASCHING, Auteur ; Matthias W. BECKMANN, Auteur ; Johannes KORNHUBER, Auteur ; Oliver KRATZ, Auteur ; Gunther H. MOLL, Auteur ; Hartmut HEINRICH, Auteur ; Anna EICHLER, Auteur Article en page(s) : p.419-431 Langues : Anglais (eng) Mots-clés : cortisol DNA methylation epigenetics pregnancy prenatal depression Index. décimale : PER Périodiques Résumé : Epigenetic DNA modifications in genes related to the hypothalamic–pituitary–adrenal (HPA) axis are discussed as a mechanism underlying the association between prenatal depression and altered child HPA activity. In a longitudinal study, DNA methylation changes related to prenatal depressive symptoms were investigated in 167 children aged 6 to 9 years. At six candidate genes, 126 cytosine–guanine dinucleotides were considered without correcting for multiple testing due to the exploratory nature of the study. Further associations with the basal child HPA activity were examined. Children exposed to prenatal depressive symptoms exhibited lower bedtime cortisol (p = .003, ?p2 = 0.07) and a steeper diurnal slope (p = .023, ?p2 = 0.06). For total cortisol release, prenatal exposure was related to lower cortisol release in boys, and higher release in girls. Furthermore, prenatal depressive symptoms were associated with altered methylation in the glucocorticoid receptor gene (NR3C1), the mineralocorticoid receptor gene (NR3C2), and the serotonin receptor gene (SLC6A4), with some sex-specific effects (p = .012–.040, ?p2 = 0.03–0.04). In boys, prenatal depressive symptoms predicted bedtime cortisol mediated by NR3C2 methylation, indirect effect = –0.07, 95% confidence interval [–0.16, –0.02]. Results indicate relations of prenatal depressive symptoms to both child basal HPA activity and DNA methylation, partially fitting a mediation model, with exposed boys and girls being affected differently. En ligne : http://dx.doi.org/10.1017/S0954579418000056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children [Texte imprimé et/ou numérique] / Valeska STONAWSKI, Auteur ; Stefan FREY, Auteur ; Yulia GOLUB, Auteur ; Nicolas ROHLEDER, Auteur ; Jennifer KRIEBEL, Auteur ; Tamme W. GOECKE, Auteur ; Peter A. FASCHING, Auteur ; Matthias W. BECKMANN, Auteur ; Johannes KORNHUBER, Auteur ; Oliver KRATZ, Auteur ; Gunther H. MOLL, Auteur ; Hartmut HEINRICH, Auteur ; Anna EICHLER, Auteur . - p.419-431. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.419-431 Mots-clés : cortisol DNA methylation epigenetics pregnancy prenatal depression Index. décimale : PER Périodiques Résumé : Epigenetic DNA modifications in genes related to the hypothalamic–pituitary–adrenal (HPA) axis are discussed as a mechanism underlying the association between prenatal depression and altered child HPA activity. In a longitudinal study, DNA methylation changes related to prenatal depressive symptoms were investigated in 167 children aged 6 to 9 years. At six candidate genes, 126 cytosine–guanine dinucleotides were considered without correcting for multiple testing due to the exploratory nature of the study. Further associations with the basal child HPA activity were examined. Children exposed to prenatal depressive symptoms exhibited lower bedtime cortisol (p = .003, ?p2 = 0.07) and a steeper diurnal slope (p = .023, ?p2 = 0.06). For total cortisol release, prenatal exposure was related to lower cortisol release in boys, and higher release in girls. Furthermore, prenatal depressive symptoms were associated with altered methylation in the glucocorticoid receptor gene (NR3C1), the mineralocorticoid receptor gene (NR3C2), and the serotonin receptor gene (SLC6A4), with some sex-specific effects (p = .012–.040, ?p2 = 0.03–0.04). In boys, prenatal depressive symptoms predicted bedtime cortisol mediated by NR3C2 methylation, indirect effect = –0.07, 95% confidence interval [–0.16, –0.02]. Results indicate relations of prenatal depressive symptoms to both child basal HPA activity and DNA methylation, partially fitting a mediation model, with exposed boys and girls being affected differently. En ligne : http://dx.doi.org/10.1017/S0954579418000056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Effects of prenatal alcohol consumption on cognitive development and ADHD?related behaviour in primary?school age: a multilevel study based on meconium ethyl glucuronide / Anna EICHLER in Journal of Child Psychology and Psychiatry, 59-2 (February 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.110-118 Titre : Effects of prenatal alcohol consumption on cognitive development and ADHD?related behaviour in primary?school age: a multilevel study based on meconium ethyl glucuronide Type de document : Texte imprimé et/ou numérique Auteurs : Anna EICHLER, Auteur ; Linda HUDLER, Auteur ; Juliane GRUNITZ, Auteur ; Jennifer GRIMM, Auteur ; Eva RAABE, Auteur ; Tamme W. GOECKE, Auteur ; Peter A. FASCHING, Auteur ; Matthias W. BECKMANN, Auteur ; Oliver KRATZ, Auteur ; Gunther H. MOLL, Auteur ; Johannes KORNHUBER, Auteur ; Hartmut HEINRICH, Auteur Article en page(s) : p.110-118 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Alcohol intake during pregnancy is considered to be a risk factor for child development. Child biomarkers of intrauterine alcohol exposure have been rarely studied. We investigated whether a meconium alcohol metabolite (ethyl glucuronide, EtG) was associated with cognitive development, ADHD?related behaviour and neurophysiological markers of attention and executive control of children at primary?school age. Methods Mothers provided self?report on prenatal alcohol consumption during their 3rd trimester. Meconium samples were collected at birth. A total of 44 children with a meconium EtG above the detection limit (?10 ng/g) and 44 nonexposed matched controls were compared. A second threshold (?154 ng/g) was applied to study the dose effects. When children reached primary?school age, mothers rated ADHD?related behaviour, child cognitive development was measured using an IQ test battery, and event?related potentials were recorded during a cued go/nogo task. Results Children in both EtG?positive groups allocated fewer attentional resources than controls to the go/nogo task (reduced P3 component in go?trials). Children with a meconium EtG above 154 ng/g were also found to have an IQ that was six points lower than the other groups. Within the EtG ? 154 ng/g group, there was a positive correlation between EtG value and ADHD?related behaviour. These significant effects were not observed in relation to the maternal self?report data. Conclusions Associations between EtG and cognitive deficits, attentional resource capacity and ADHD?related behaviour could be documented with effects that were partially dose?dependent. In addition to maternal self?reports, this biomarker of intrauterine alcohol exposure may be considered as a predictor of child development. En ligne : https://doi.org/10.1111/jcpp.12794 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Effects of prenatal alcohol consumption on cognitive development and ADHD?related behaviour in primary?school age: a multilevel study based on meconium ethyl glucuronide [Texte imprimé et/ou numérique] / Anna EICHLER, Auteur ; Linda HUDLER, Auteur ; Juliane GRUNITZ, Auteur ; Jennifer GRIMM, Auteur ; Eva RAABE, Auteur ; Tamme W. GOECKE, Auteur ; Peter A. FASCHING, Auteur ; Matthias W. BECKMANN, Auteur ; Oliver KRATZ, Auteur ; Gunther H. MOLL, Auteur ; Johannes KORNHUBER, Auteur ; Hartmut HEINRICH, Auteur . - p.110-118. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.110-118 Index. décimale : PER Périodiques Résumé : Background Alcohol intake during pregnancy is considered to be a risk factor for child development. Child biomarkers of intrauterine alcohol exposure have been rarely studied. We investigated whether a meconium alcohol metabolite (ethyl glucuronide, EtG) was associated with cognitive development, ADHD?related behaviour and neurophysiological markers of attention and executive control of children at primary?school age. Methods Mothers provided self?report on prenatal alcohol consumption during their 3rd trimester. Meconium samples were collected at birth. A total of 44 children with a meconium EtG above the detection limit (?10 ng/g) and 44 nonexposed matched controls were compared. A second threshold (?154 ng/g) was applied to study the dose effects. When children reached primary?school age, mothers rated ADHD?related behaviour, child cognitive development was measured using an IQ test battery, and event?related potentials were recorded during a cued go/nogo task. Results Children in both EtG?positive groups allocated fewer attentional resources than controls to the go/nogo task (reduced P3 component in go?trials). Children with a meconium EtG above 154 ng/g were also found to have an IQ that was six points lower than the other groups. Within the EtG ? 154 ng/g group, there was a positive correlation between EtG value and ADHD?related behaviour. These significant effects were not observed in relation to the maternal self?report data. Conclusions Associations between EtG and cognitive deficits, attentional resource capacity and ADHD?related behaviour could be documented with effects that were partially dose?dependent. In addition to maternal self?reports, this biomarker of intrauterine alcohol exposure may be considered as a predictor of child development. En ligne : https://doi.org/10.1111/jcpp.12794 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

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