A controlled study of mercury levels in hair samples of children with autism as compared to their typically developing siblings / P. GAIL WILLIAMS in Research in Autism Spectrum Disorders, 2-1 (January/March 2008)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 2-1 (January/March 2008) . - p.170-175 Titre : A controlled study of mercury levels in hair samples of children with autism as compared to their typically developing siblings Type de document : Texte imprimé et/ou numérique Auteurs : P. GAIL WILLIAMS, Auteur ; Joseph H. HERSH, Auteur ; AnnaMary ALLARD, Auteur ; Lonnie L. SEARS, Auteur Année de publication : 2008 Article en page(s) : p.170-175 Langues : Anglais (eng) Mots-clés : Autism Mercury-toxicity Hair-analysis Index. décimale : PER Périodiques Résumé : Autism is a developmental disability characterized by severe, pervasive deficits in social interaction, communication and range of interests and activities. The neurobiologic basis of autism is well accepted, although the specific etiology is unknown. It has been theorized that autism may result from a combination of predisposing genes and environmental factors. While autism has a known association with environmental factors such as rubella and valproic acid exposure in utero, other proposed environmental mechanisms such as mercury toxicity or other heavy metal exposure have minimal research support. Despite this fact, interventions including oral and topical chelation therapy are being used to treat autism following evaluation of hair, blood, or urine samples for heavy metal toxicity. In this study, hair samples were obtained from 15 children with autism between the ages of 2 and 6 years and 16 controls in the same age range who are the siblings of the subjects. The hair samples were obtained according to lab. specifications and submitted in a blind fashion to Doctor's Data Lab. for measurement of mercury levels. Data from the two groups were then compared using T-test. No significant differences were found between mercury levels for the two groups. This study raises questions about the theory that mercury toxicity causes autism and points to the difficulty in quantifying chronic mercury exposure through currently available laboratory measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] A controlled study of mercury levels in hair samples of children with autism as compared to their typically developing siblings [Texte imprimé et/ou numérique] / P. GAIL WILLIAMS, Auteur ; Joseph H. HERSH, Auteur ; AnnaMary ALLARD, Auteur ; Lonnie L. SEARS, Auteur . - 2008 . - p.170-175. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 2-1 (January/March 2008) . - p.170-175 Mots-clés : Autism Mercury-toxicity Hair-analysis Index. décimale : PER Périodiques Résumé : Autism is a developmental disability characterized by severe, pervasive deficits in social interaction, communication and range of interests and activities. The neurobiologic basis of autism is well accepted, although the specific etiology is unknown. It has been theorized that autism may result from a combination of predisposing genes and environmental factors. While autism has a known association with environmental factors such as rubella and valproic acid exposure in utero, other proposed environmental mechanisms such as mercury toxicity or other heavy metal exposure have minimal research support. Despite this fact, interventions including oral and topical chelation therapy are being used to treat autism following evaluation of hair, blood, or urine samples for heavy metal toxicity. In this study, hair samples were obtained from 15 children with autism between the ages of 2 and 6 years and 16 controls in the same age range who are the siblings of the subjects. The hair samples were obtained according to lab. specifications and submitted in a blind fashion to Doctor's Data Lab. for measurement of mercury levels. Data from the two groups were then compared using T-test. No significant differences were found between mercury levels for the two groups. This study raises questions about the theory that mercury toxicity causes autism and points to the difficulty in quantifying chronic mercury exposure through currently available laboratory measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism / Estate M. SOKHADZE in Journal of Autism and Developmental Disorders, 39-4 (April 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-4 (April 2009) . - p.619-634 Titre : Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Estate M. SOKHADZE, Auteur ; Manuel F. CASANOVA, Auteur ; Lonnie L. SEARS, Auteur ; Ayman S. EL-BAZ, Auteur ; Grace MATHAI, Auteur ; Joshua M. BARUTH, Auteur Année de publication : 2009 Article en page(s) : p.619-634 Langues : Anglais (eng) Mots-clés : Autism Minicolumns Event-related-potentials Electroencephalography Gamma-frequencies Index. décimale : PER Périodiques Résumé : Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism. En ligne : http://dx.doi.org/10.1007/s10803-008-0662-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=706 [article] Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism [Texte imprimé et/ou numérique] / Estate M. SOKHADZE, Auteur ; Manuel F. CASANOVA, Auteur ; Lonnie L. SEARS, Auteur ; Ayman S. EL-BAZ, Auteur ; Grace MATHAI, Auteur ; Joshua M. BARUTH, Auteur . - 2009 . - p.619-634. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-4 (April 2009) . - p.619-634 Mots-clés : Autism Minicolumns Event-related-potentials Electroencephalography Gamma-frequencies Index. décimale : PER Périodiques Résumé : Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism. En ligne : http://dx.doi.org/10.1007/s10803-008-0662-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=706

Introduction to Autism Spectrum Disorder / Grace MATHAI KURAVACKEL

Public ISBD in Autism Spectrum Disorder: Neuromodulation, Neurofeedback, and Sensory Integration Approaches to Research and Treatment / Estate M. SOKHADZE Titre : Introduction to Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Grace MATHAI KURAVACKEL, Auteur ; Lonnie L. SEARS, Auteur Année de publication : 2019 Importance : p.1-18 Langues : Anglais (eng) Index. décimale : AUT-F AUT-F - L'Autisme - Soins Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399 in Autism Spectrum Disorder: Neuromodulation, Neurofeedback, and Sensory Integration Approaches to Research and Treatment / Estate M. SOKHADZE Introduction to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Grace MATHAI KURAVACKEL, Auteur ; Lonnie L. SEARS, Auteur . - 2019 . - p.1-18. Langues : Anglais (eng) Index. décimale : AUT-F AUT-F - L'Autisme - Soins Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399

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