[article]
| Titre : |
Understanding discrepancy in autism epidemiology in view of underpinning genetic architecture: Lessons learnt from studies in consanguineous populations |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Ahmed B. IDRIS, Auteur ; Watfa AL-MAMARI, Auteur ; Reem ABDULRAHIM, Auteur ; Abeer ALSAYEGH, Auteur |
| Article en page(s) : |
101944 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
This short commentary aims to shed light on the discrepancy in the epidemiological findings and underlying genetic architecture of Autism Spectrum Disorder (ASD) between demographically distinct populations; consanguineous and non-consanguineous. Here we discuss the effect of advanced paternal age as a risk factor acting as a proxy for potential underlying genetic mechanisms. On that account, this narrative postulates that disparity might possibly be explained in the context of the differences in genetic makeup and abundance of recessive mutations in the highly consanguineous populations. |
| En ligne : |
https://doi.org/10.1016/j.rasd.2022.101944 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 |
in Research in Autism Spectrum Disorders > 93 (May 2022) . - 101944
[article] Understanding discrepancy in autism epidemiology in view of underpinning genetic architecture: Lessons learnt from studies in consanguineous populations [Texte imprimé et/ou numérique] / Ahmed B. IDRIS, Auteur ; Watfa AL-MAMARI, Auteur ; Reem ABDULRAHIM, Auteur ; Abeer ALSAYEGH, Auteur . - 101944. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 93 (May 2022) . - 101944
| Index. décimale : |
PER Périodiques |
| Résumé : |
This short commentary aims to shed light on the discrepancy in the epidemiological findings and underlying genetic architecture of Autism Spectrum Disorder (ASD) between demographically distinct populations; consanguineous and non-consanguineous. Here we discuss the effect of advanced paternal age as a risk factor acting as a proxy for potential underlying genetic mechanisms. On that account, this narrative postulates that disparity might possibly be explained in the context of the differences in genetic makeup and abundance of recessive mutations in the highly consanguineous populations. |
| En ligne : |
https://doi.org/10.1016/j.rasd.2022.101944 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 |
|
Understanding discrepancy in autism epidemiology in view of underpinning genetic architecture: Lessons learnt from studies in consanguineous populations in Research in Autism Spectrum Disorders, 93 (May 2022)
