Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187 Titre : Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur Année de publication : 2010 Article en page(s) : p.180-187 Langues : Anglais (eng) Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant. Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 [article] Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur . - 2010 . - p.180-187. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187 Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant. Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941

Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 49-4 (April 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440 Titre : Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur Année de publication : 2008 Article en page(s) : p.433–440 Langues : Anglais (eng) Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed. Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles. Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20. Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur . - 2008 . - p.433–440. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440 Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed. Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles. Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20. Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

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