[article]
| Titre : |
Sexual Dimorphism in Telomere Length in Childhood Autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Yasin PANAHI, Auteur ; Fahimeh SALASAR MOGHADDAM, Auteur ; Khadijeh BABAEI, Auteur ; Mohammad EFTEKHAR, Auteur ; Reza SHERVIN BADV, Auteur ; Mohammad Reza ESKANDARI, Auteur ; Mohammad VAFAEE-SHAHI, Auteur ; Hamid PEZESHK, Auteur ; Mehrdad PEDRAM, Auteur |
| Article en page(s) : |
p.2050-2061 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorders (ASD) are strikingly more prevalent in males, but the molecular mechanisms responsible for ASD sex-differential risk are poorly understood. Abnormally shorter telomeres have been associated with autism. Examination of relative telomere lengths (RTL) among non-syndromic male (N=14) and female (N=10) children with autism revealed that only autistic male children had significantly shorter RTL than typically-developing controls (N=24) and paired siblings (N=10). While average RTL of autistic girls did not differ significantly from controls, it was substantially longer than autistic boys. Our findings indicate a sexually-dimorphic pattern of RTL in childhood autism and could have important implications for RTL as a potential biomarker and the role/s of telomeres in the molecular mechanisms responsible for ASD sex-biased prevalence and etiology. |
| En ligne : |
https://doi.org/10.1007/s10803-022-05486-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 |
in Journal of Autism and Developmental Disorders > 53-5 (May 2023) . - p.2050-2061
[article] Sexual Dimorphism in Telomere Length in Childhood Autism [Texte imprimé et/ou numérique] / Yasin PANAHI, Auteur ; Fahimeh SALASAR MOGHADDAM, Auteur ; Khadijeh BABAEI, Auteur ; Mohammad EFTEKHAR, Auteur ; Reza SHERVIN BADV, Auteur ; Mohammad Reza ESKANDARI, Auteur ; Mohammad VAFAEE-SHAHI, Auteur ; Hamid PEZESHK, Auteur ; Mehrdad PEDRAM, Auteur . - p.2050-2061. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 53-5 (May 2023) . - p.2050-2061
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorders (ASD) are strikingly more prevalent in males, but the molecular mechanisms responsible for ASD sex-differential risk are poorly understood. Abnormally shorter telomeres have been associated with autism. Examination of relative telomere lengths (RTL) among non-syndromic male (N=14) and female (N=10) children with autism revealed that only autistic male children had significantly shorter RTL than typically-developing controls (N=24) and paired siblings (N=10). While average RTL of autistic girls did not differ significantly from controls, it was substantially longer than autistic boys. Our findings indicate a sexually-dimorphic pattern of RTL in childhood autism and could have important implications for RTL as a potential biomarker and the role/s of telomeres in the molecular mechanisms responsible for ASD sex-biased prevalence and etiology. |
| En ligne : |
https://doi.org/10.1007/s10803-022-05486-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 |
|
Sexual Dimorphism in Telomere Length in Childhood Autism in Journal of Autism and Developmental Disorders, 53-5 (May 2023)
