[article] 
inJournal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500

Titre :	Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur
Article en page(s) :	p.1492-1500
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5?years old) and then approximately every 2?years for a mean of 10.6?years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions.
En ligne :	https://doi.org/10.1111/jcpp.13739
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

[article] Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder [Texte imprimé et/ou numérique] / Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur . - p.1492-1500.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500

Index. décimale :	PER Périodiques
Résumé :	Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5?years old) and then approximately every 2?years for a mean of 10.6?years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions.
En ligne :	https://doi.org/10.1111/jcpp.13739
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512