[article] 
inJournal of Child Psychology and Psychiatry > 49-7 (July 2008) . - p.691 - 704

Titre :	Research Review: Dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Gail TRIPP, Auteur ; Jeff R. WICKENS, Auteur
Année de publication :	2008
Article en page(s) :	p.691 - 704
Langues :	Anglais (eng)
Mots-clés :	Attention-deficit-hyperactivity-disorder reinforcement mechanisms neurobiology dopamine
Index. décimale :	PER Périodiques
Résumé :	This review considers the hypothesis that changes in dopamine signalling might account for altered sensitivity to positive reinforcement in children with ADHD. The existing evidence regarding dopamine cell activity in relation to positive reinforcement is reviewed. We focus on the anticipatory firing of dopamine cells brought about by a transfer of dopamine cell responses to cues that precede reinforcers. It is proposed that in children with ADHD there is diminished anticipatory dopamine cell firing, which we call the dopamine transfer deficit (DTD). The DTD theory leads to specific and testable predictions for human and animal research. The extent to which DTD explains symptoms of ADHD and effects of pharmacological interventions is discussed. We conclude by considering the neural changes underlying the etiology of DTD.
En ligne :	http://dx.doi.org/10.1111/j.1469-7610.2007.01851.x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540

[article] Research Review: Dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD [Texte imprimé et/ou numérique] / Gail TRIPP, Auteur ; Jeff R. WICKENS, Auteur . - 2008 . - p.691 - 704.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-7 (July 2008) . - p.691 - 704

Mots-clés :	Attention-deficit-hyperactivity-disorder reinforcement mechanisms neurobiology dopamine
Index. décimale :	PER Périodiques
Résumé :	This review considers the hypothesis that changes in dopamine signalling might account for altered sensitivity to positive reinforcement in children with ADHD. The existing evidence regarding dopamine cell activity in relation to positive reinforcement is reviewed. We focus on the anticipatory firing of dopamine cells brought about by a transfer of dopamine cell responses to cues that precede reinforcers. It is proposed that in children with ADHD there is diminished anticipatory dopamine cell firing, which we call the dopamine transfer deficit (DTD). The DTD theory leads to specific and testable predictions for human and animal research. The extent to which DTD explains symptoms of ADHD and effects of pharmacological interventions is discussed. We conclude by considering the neural changes underlying the etiology of DTD.
En ligne :	http://dx.doi.org/10.1111/j.1469-7610.2007.01851.x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540