Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised / H. C. GUSTAFSSON in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.773-785 Titre : Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised Type de document : Texte imprimé et/ou numérique Auteurs : H. C. GUSTAFSSON, Auteur ; S. H. GOODMAN, Auteur ; T. FENG, Auteur ; J. CHOI, Auteur ; S. LEE, Auteur ; D. J. NEWPORT, Auteur ; B. KNIGHT, Auteur ; B. PINGETON, Auteur ; Z. N. STOWE, Auteur ; C. MONK, Auteur Article en page(s) : p.773-785 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychotropic medication use and psychiatric symptoms during pregnancy each are associated with adverse neurodevelopmental outcomes in offspring. Commonly, studies considering medication effects do not adequately assess symptoms, nor evaluate children when the effects are believed to occur, the fetal period. This study examined maternal serotonin reuptake inhibitor and polypharmacy use in relation to serial assessments of five indices of fetal neurobehavior and Bayley Scales of Infant Development at 12 months in N = 161 socioeconomically advantaged, non-Hispanic White women with a shared risk phenotype, diagnosed major depressive disorder. On average fetuses showed the expected development over gestation. In contrast, infant average Bayley psychomotor and mental development scores were low (M = 84.10 and M = 89.92, range of normal limits 85-114) with rates of delay more than 2-3 times what would be expected based on this measure's normative data. Controlling for prenatal and postnatal depressive symptoms, prenatal medication effects on neurobehavioral development were largely undetected in the fetus and infant. Mental health care directed primarily at symptoms may not address the additional psychosocial needs of women parenting infants. Speculatively, prenatal serotonin reuptake inhibitor exposure may act as a plasticity rather than risk factor, potentially enhancing receptivity to a nonoptimal postnatal environment in some mother-infant dyads. En ligne : http://dx.doi.org/10.1017/s0954579418000639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised [Texte imprimé et/ou numérique] / H. C. GUSTAFSSON, Auteur ; S. H. GOODMAN, Auteur ; T. FENG, Auteur ; J. CHOI, Auteur ; S. LEE, Auteur ; D. J. NEWPORT, Auteur ; B. KNIGHT, Auteur ; B. PINGETON, Auteur ; Z. N. STOWE, Auteur ; C. MONK, Auteur . - p.773-785. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.773-785 Index. décimale : PER Périodiques Résumé : Psychotropic medication use and psychiatric symptoms during pregnancy each are associated with adverse neurodevelopmental outcomes in offspring. Commonly, studies considering medication effects do not adequately assess symptoms, nor evaluate children when the effects are believed to occur, the fetal period. This study examined maternal serotonin reuptake inhibitor and polypharmacy use in relation to serial assessments of five indices of fetal neurobehavior and Bayley Scales of Infant Development at 12 months in N = 161 socioeconomically advantaged, non-Hispanic White women with a shared risk phenotype, diagnosed major depressive disorder. On average fetuses showed the expected development over gestation. In contrast, infant average Bayley psychomotor and mental development scores were low (M = 84.10 and M = 89.92, range of normal limits 85-114) with rates of delay more than 2-3 times what would be expected based on this measure's normative data. Controlling for prenatal and postnatal depressive symptoms, prenatal medication effects on neurobehavioral development were largely undetected in the fetus and infant. Mental health care directed primarily at symptoms may not address the additional psychosocial needs of women parenting infants. Speculatively, prenatal serotonin reuptake inhibitor exposure may act as a plasticity rather than risk factor, potentially enhancing receptivity to a nonoptimal postnatal environment in some mother-infant dyads. En ligne : http://dx.doi.org/10.1017/s0954579418000639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Opening windows of opportunities: Evidence for interventions to prevent or treat depression in pregnant women being associated with changes in offspring's developmental trajectories of psychopathology risk / S. H. GOODMAN in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.1179-1196 Titre : Opening windows of opportunities: Evidence for interventions to prevent or treat depression in pregnant women being associated with changes in offspring's developmental trajectories of psychopathology risk Type de document : Texte imprimé et/ou numérique Auteurs : S. H. GOODMAN, Auteur ; K. A. CULLUM, Auteur ; S. DIMIDJIAN, Auteur ; L. M. RIVER, Auteur ; C. Y. KIM, Auteur Article en page(s) : p.1179-1196 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although animal models and correlational studies support a model of fetal programming as a mechanism in the transmission of risk for psychopathology from parents to children, the experimental studies that are required to empirically test the model with the human prenatal dyad are scarce. With a systematic review and meta-analysis of the literature, we critically examined the evidence regarding the neurobiological and behavioral changes in infants as a function of randomized clinical trials to prevent or reduce maternal depression during pregnancy, treating randomized clinical trials as experiments testing the fetal programming model. Based on 25 articles that met inclusion criteria, we found support for interventions designed to change maternal prenatal mood being associated with changes in offspring functioning, but with a very small effect size. Effect sizes ranged broadly, and were higher for younger children. The findings enhance understanding of putative mechanisms in the transmission of risk from women's prenatal depression to infants' vulnerabilities to, and early signs of, the development of psychopathology. We note limitations of the literature and suggest solutions to advance understanding of how preventing or treating depression in pregnant women might disrupt the transmission of risk to the infants. En ligne : http://dx.doi.org/10.1017/s0954579418000536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Opening windows of opportunities: Evidence for interventions to prevent or treat depression in pregnant women being associated with changes in offspring's developmental trajectories of psychopathology risk [Texte imprimé et/ou numérique] / S. H. GOODMAN, Auteur ; K. A. CULLUM, Auteur ; S. DIMIDJIAN, Auteur ; L. M. RIVER, Auteur ; C. Y. KIM, Auteur . - p.1179-1196. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.1179-1196 Index. décimale : PER Périodiques Résumé : Although animal models and correlational studies support a model of fetal programming as a mechanism in the transmission of risk for psychopathology from parents to children, the experimental studies that are required to empirically test the model with the human prenatal dyad are scarce. With a systematic review and meta-analysis of the literature, we critically examined the evidence regarding the neurobiological and behavioral changes in infants as a function of randomized clinical trials to prevent or reduce maternal depression during pregnancy, treating randomized clinical trials as experiments testing the fetal programming model. Based on 25 articles that met inclusion criteria, we found support for interventions designed to change maternal prenatal mood being associated with changes in offspring functioning, but with a very small effect size. Effect sizes ranged broadly, and were higher for younger children. The findings enhance understanding of putative mechanisms in the transmission of risk from women's prenatal depression to infants' vulnerabilities to, and early signs of, the development of psychopathology. We note limitations of the literature and suggest solutions to advance understanding of how preventing or treating depression in pregnant women might disrupt the transmission of risk to the infants. En ligne : http://dx.doi.org/10.1017/s0954579418000536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

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