[article] 
inJournal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.1101-1111

Titre :	Sociability: Comparing the Effect of Chlorpyrifos with Valproic Acid
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Miguel MORALES-NAVAS, Auteur ; Cristian PEREZ-FERNANDEZ, Auteur ; Sergio CASTAÑO-CASTAÑO, Auteur ; Ainhoa SÁNCHEZ-GIL, Auteur ; María Teresa COLOMINA, Auteur ; Xavier LEINEKUGEL, Auteur ; Fernando SÁNCHEZ-SANTED, Auteur
Article en page(s) :	p.1101-1111
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	In recent years, exposures to organophosphate pesticide have been highlighted as a possible cause or aggravating factor of autism spectrum disorder (ASD). The present study examined if Wistar rats prenatally exposed to chlorpyrifos (CPF) at a dose of 1 mg/kg in GD 12.5-15.5 could express similar behaviors to those exposed to valproic acid (VPA, 400 mg/kg) during the same administration window, which is an accepted animal model of autism. The 3-chambered test was employed to evaluate sociability and reaction to social novelty in two experiments, the first in adolescence and the second in adulthood. The results obtained in this study show that animals prenatally treated with CPF or VPA show a similar behavioral phenotype compared to the control group (CNT). In adolescence, the CPF animals showed a negative index in the reaction to social novelty, followed closely by the VPA, while both experimental groups showed a recovery in this aspect during adulthood. This study therefore provides evidence to suggest that prenatal exposure to CPF in rats could have similar effects on certain components of sociability to those seen in autistic models.
En ligne :	https://doi.org/10.1007/s10803-024-06263-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=549

[article] Sociability: Comparing the Effect of Chlorpyrifos with Valproic Acid [Texte imprimé et/ou numérique] / Miguel MORALES-NAVAS, Auteur ; Cristian PEREZ-FERNANDEZ, Auteur ; Sergio CASTAÑO-CASTAÑO, Auteur ; Ainhoa SÁNCHEZ-GIL, Auteur ; María Teresa COLOMINA, Auteur ; Xavier LEINEKUGEL, Auteur ; Fernando SÁNCHEZ-SANTED, Auteur . - p.1101-1111.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.1101-1111

Index. décimale :	PER Périodiques
Résumé :	In recent years, exposures to organophosphate pesticide have been highlighted as a possible cause or aggravating factor of autism spectrum disorder (ASD). The present study examined if Wistar rats prenatally exposed to chlorpyrifos (CPF) at a dose of 1 mg/kg in GD 12.5-15.5 could express similar behaviors to those exposed to valproic acid (VPA, 400 mg/kg) during the same administration window, which is an accepted animal model of autism. The 3-chambered test was employed to evaluate sociability and reaction to social novelty in two experiments, the first in adolescence and the second in adulthood. The results obtained in this study show that animals prenatally treated with CPF or VPA show a similar behavioral phenotype compared to the control group (CNT). In adolescence, the CPF animals showed a negative index in the reaction to social novelty, followed closely by the VPA, while both experimental groups showed a recovery in this aspect during adulthood. This study therefore provides evidence to suggest that prenatal exposure to CPF in rats could have similar effects on certain components of sociability to those seen in autistic models.
En ligne :	https://doi.org/10.1007/s10803-024-06263-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=549