[article]
| Titre : |
Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Xingxing LIAO, Auteur ; Kaiyue HAN, Auteur ; Maoyuan NIU, Auteur ; Jiarou CHEN, Auteur ; Xianna Wang, Auteur ; Jianjun LIU, Auteur ; Yan ZHANG, Auteur ; Hao Zhang, Auteur |
| Article en page(s) : |
p.1497-1512 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
autism spectrum disorder insulin-like growth factor-1 meta-analysis systematic review thyroid hormone |
| Index. décimale : |
PER Périodiques |
| Résumé : |
ABSTRACT The action of the thyroid hormones and insulin-like growth factor 1 (IGF-1) is interdependent. The levels of thyroid hormone and IGF-1 were reported to be altered in individuals with autism spectrum disorder (ASD), but the results were controversial. This study aims to compare levels of thyroxine, triiodothyronine, thyroid stimulating hormone, and IGF-1 between the ASD group and neurotypical controls. PubMed, Web of Science, Cochrane, and Embase databases were searched for eligible observational studies. We calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) of our data using a random or fixed effect model. The search strategy provided a total of 1710 articles, of which 16 articles were quantitatively analyzed. The total number of included participants was 2399 (1285 cases and 1114 controls). The meta-analysis revealed no significantly changed blood levels of thyroxine, free triiodothyronine, free thyroxine, and IGF-1 of subjects with ASD compared to non-autistic controls. The blood TSH levels were significantly lower in ASD subjects than in controls (n?=?859, Hedges' g?=??1.18, 95% CI: ?2.17 to ?0.20, p?=?0.02). Subgroup-analysis results showed that blood free triiodothyronine (n?=?153, Hedges' g?=??0.74, 95% CI: ?1.08 to ?0.40, p? |
| En ligne : |
https://doi.org/10.1002/aur.70052 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 |
in Autism Research > 18-7 (July 2025) . - p.1497-1512
[article] Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Xingxing LIAO, Auteur ; Kaiyue HAN, Auteur ; Maoyuan NIU, Auteur ; Jiarou CHEN, Auteur ; Xianna Wang, Auteur ; Jianjun LIU, Auteur ; Yan ZHANG, Auteur ; Hao Zhang, Auteur . - p.1497-1512. Langues : Anglais ( eng) in Autism Research > 18-7 (July 2025) . - p.1497-1512
| Mots-clés : |
autism spectrum disorder insulin-like growth factor-1 meta-analysis systematic review thyroid hormone |
| Index. décimale : |
PER Périodiques |
| Résumé : |
ABSTRACT The action of the thyroid hormones and insulin-like growth factor 1 (IGF-1) is interdependent. The levels of thyroid hormone and IGF-1 were reported to be altered in individuals with autism spectrum disorder (ASD), but the results were controversial. This study aims to compare levels of thyroxine, triiodothyronine, thyroid stimulating hormone, and IGF-1 between the ASD group and neurotypical controls. PubMed, Web of Science, Cochrane, and Embase databases were searched for eligible observational studies. We calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) of our data using a random or fixed effect model. The search strategy provided a total of 1710 articles, of which 16 articles were quantitatively analyzed. The total number of included participants was 2399 (1285 cases and 1114 controls). The meta-analysis revealed no significantly changed blood levels of thyroxine, free triiodothyronine, free thyroxine, and IGF-1 of subjects with ASD compared to non-autistic controls. The blood TSH levels were significantly lower in ASD subjects than in controls (n?=?859, Hedges' g?=??1.18, 95% CI: ?2.17 to ?0.20, p?=?0.02). Subgroup-analysis results showed that blood free triiodothyronine (n?=?153, Hedges' g?=??0.74, 95% CI: ?1.08 to ?0.40, p? |
| En ligne : |
https://doi.org/10.1002/aur.70052 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 |
|
Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis in Autism Research, 18-7 (July 2025)
