[article]
| Titre : |
Using causal methods to map symptoms to brain circuits in neurodevelopment disorders: moving from identifying correlates to developing treatments |
| Type de document : |
texte imprimé |
| Auteurs : |
Alexander Li COHEN, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Brain/diagnostic imaging Neurodevelopmental Disorders/therapy Neurofeedback/methods Neuroimaging/methods Transcranial Magnetic Stimulation/methods Neurodevelopmental disorders Real-time fMRI neurofeedback Transcranial direct current stimulation Transcranial magnetic Stimulation Transdiagnostic symptoms Translational neuroimaging |
| Index. décimale : |
PER Périodiques |
| Résumé : |
A wide variety of model systems and experimental techniques can provide insight into the structure and function of the human brain in typical development and in neurodevelopmental disorders. Unfortunately, this work, whether based on manipulation of animal models or observational and correlational methods in humans, has a high attrition rate in translating scientific discovery into practicable treatments and therapies for neurodevelopmental disorders.With new computational and neuromodulatory approaches to interrogating brain networks, opportunities exist for "bedside-to bedside-translation" with a potentially shorter path to therapeutic options. Specifically, methods like lesion network mapping can identify brain networks involved in the generation of complex symptomatology, both from acute onset lesion-related symptoms and from focal developmental anomalies. Traditional neuroimaging can examine the generalizability of these findings to idiopathic populations, while non-invasive neuromodulation techniques such as transcranial magnetic stimulation provide the ability to do targeted activation or inhibition of these specific brain regions and networks. In parallel, real-time functional MRI neurofeedback also allow for endogenous neuromodulation of specific targets that may be out of reach for transcranial exogenous methods.Discovery of novel neuroanatomical circuits for transdiagnostic symptoms and neuroimaging-based endophenotypes may now be feasible for neurodevelopmental disorders using data from cohorts with focal brain anomalies. These novel circuits, after validation in large-scale highly characterized research cohorts and tested prospectively using noninvasive neuromodulation and neurofeedback techniques, may represent a new pathway for symptom-based targeted therapy. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-022-09433-1 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 |
in Journal of Neurodevelopmental Disorders > 14 (2022)
[article] Using causal methods to map symptoms to brain circuits in neurodevelopment disorders: moving from identifying correlates to developing treatments [texte imprimé] / Alexander Li COHEN, Auteur. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 14 (2022)
| Mots-clés : |
Brain/diagnostic imaging Neurodevelopmental Disorders/therapy Neurofeedback/methods Neuroimaging/methods Transcranial Magnetic Stimulation/methods Neurodevelopmental disorders Real-time fMRI neurofeedback Transcranial direct current stimulation Transcranial magnetic Stimulation Transdiagnostic symptoms Translational neuroimaging |
| Index. décimale : |
PER Périodiques |
| Résumé : |
A wide variety of model systems and experimental techniques can provide insight into the structure and function of the human brain in typical development and in neurodevelopmental disorders. Unfortunately, this work, whether based on manipulation of animal models or observational and correlational methods in humans, has a high attrition rate in translating scientific discovery into practicable treatments and therapies for neurodevelopmental disorders.With new computational and neuromodulatory approaches to interrogating brain networks, opportunities exist for "bedside-to bedside-translation" with a potentially shorter path to therapeutic options. Specifically, methods like lesion network mapping can identify brain networks involved in the generation of complex symptomatology, both from acute onset lesion-related symptoms and from focal developmental anomalies. Traditional neuroimaging can examine the generalizability of these findings to idiopathic populations, while non-invasive neuromodulation techniques such as transcranial magnetic stimulation provide the ability to do targeted activation or inhibition of these specific brain regions and networks. In parallel, real-time functional MRI neurofeedback also allow for endogenous neuromodulation of specific targets that may be out of reach for transcranial exogenous methods.Discovery of novel neuroanatomical circuits for transdiagnostic symptoms and neuroimaging-based endophenotypes may now be feasible for neurodevelopmental disorders using data from cohorts with focal brain anomalies. These novel circuits, after validation in large-scale highly characterized research cohorts and tested prospectively using noninvasive neuromodulation and neurofeedback techniques, may represent a new pathway for symptom-based targeted therapy. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-022-09433-1 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 |
|  |
Using causal methods to map symptoms to brain circuits in neurodevelopment disorders: moving from identifying correlates to developing treatments in Journal of Neurodevelopmental Disorders, 14 (2022)
