[article]
| Titre : |
Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity |
| Type de document : |
texte imprimé |
| Auteurs : |
Maj LIIWAND, Auteur ; Joni HAIKONEN, Auteur ; Bojana KOKINOVIC, Auteur ; Svetlana M. MOLCHANOVA, Auteur ; Teemu AITTA-AHO, Auteur ; Sari E. LAURI, Auteur ; Maria RYAZANTSEVA, Auteur |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The MECP2 gene is located on the X chromosome and encodes a methyl-CpG-binding protein 2 involved in transcriptional regulation. Loss-of-function mutations in the MECP2 gene lead to Rett syndrome, a severe neurodevelopmental disorder. The clinical picture of Rett syndrome includes, among other symptoms, social deficits, learning impairment, and heightened anxiety. The amygdala is a brain region responsible for emotional learning and is involved in the regulation of social behaviour as well as fear and anxiety. Parvalbumin interneurons tightly control the excitability, oscillation and synchronisation of the amygdala network, which are relevant to its functions. Here, we investigated the effects of Mecp2 gene ablation in parvalbumin interneurons on the microcircuit and functional connectivity of the mouse amygdala. |
| En ligne : |
https://doi.org/10.1186/s13229-025-00699-5 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 |
in Molecular Autism > 17 (2026)
[article] Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity [texte imprimé] / Maj LIIWAND, Auteur ; Joni HAIKONEN, Auteur ; Bojana KOKINOVIC, Auteur ; Svetlana M. MOLCHANOVA, Auteur ; Teemu AITTA-AHO, Auteur ; Sari E. LAURI, Auteur ; Maria RYAZANTSEVA, Auteur. Langues : Anglais ( eng) in Molecular Autism > 17 (2026)
| Index. décimale : |
PER Périodiques |
| Résumé : |
The MECP2 gene is located on the X chromosome and encodes a methyl-CpG-binding protein 2 involved in transcriptional regulation. Loss-of-function mutations in the MECP2 gene lead to Rett syndrome, a severe neurodevelopmental disorder. The clinical picture of Rett syndrome includes, among other symptoms, social deficits, learning impairment, and heightened anxiety. The amygdala is a brain region responsible for emotional learning and is involved in the regulation of social behaviour as well as fear and anxiety. Parvalbumin interneurons tightly control the excitability, oscillation and synchronisation of the amygdala network, which are relevant to its functions. Here, we investigated the effects of Mecp2 gene ablation in parvalbumin interneurons on the microcircuit and functional connectivity of the mouse amygdala. |
| En ligne : |
https://doi.org/10.1186/s13229-025-00699-5 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 |
|  |
Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity in Molecular Autism, 17 (2026)
