[article] 
inJournal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1966-1975

Titre :	Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; Stefanie JERNIGAN, Auteur ; Amanda HUBANKS, Auteur ; Shannon ROSE, Auteur ; David W. GAYLOR, Auteur
Année de publication :	2008
Article en page(s) :	p.1966-1975
Note générale :	An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-008-0614-2
Langues :	Anglais (eng)
Mots-clés :	Autism Homocysteine Glutathione DNA-methylation Parents
Index. décimale :	PER Périodiques
Résumé :	An integrated metabolic profile reflects the combined influence of genetic, epigenetic, and environmental factors that affect the candidate pathway of interest. Recent evidence suggests that some autistic children may have reduced detoxification capacity and may be under chronic oxidative stress. Based on reports of abnormal methionine and glutathione metabolism in autistic children, it was of interest to examine the same metabolic profile in the parents. The results indicated that parents share similar metabolic deficits in methylation capacity and glutathione-dependent antioxidant/detoxification capacity observed in many autistic children. Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0591-5
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642

[article] Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism [Texte imprimé et/ou numérique] / S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; Stefanie JERNIGAN, Auteur ; Amanda HUBANKS, Auteur ; Shannon ROSE, Auteur ; David W. GAYLOR, Auteur . - 2008 . - p.1966-1975.
An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-008-0614-2
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1966-1975

Mots-clés :	Autism Homocysteine Glutathione DNA-methylation Parents
Index. décimale :	PER Périodiques
Résumé :	An integrated metabolic profile reflects the combined influence of genetic, epigenetic, and environmental factors that affect the candidate pathway of interest. Recent evidence suggests that some autistic children may have reduced detoxification capacity and may be under chronic oxidative stress. Based on reports of abnormal methionine and glutathione metabolism in autistic children, it was of interest to examine the same metabolic profile in the parents. The results indicated that parents share similar metabolic deficits in methylation capacity and glutathione-dependent antioxidant/detoxification capacity observed in many autistic children. Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0591-5
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642