[article] 
inJournal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1331-1338

Titre :	Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur
Année de publication :	2008
Article en page(s) :	p.1331-1338
Langues :	Anglais (eng)
Mots-clés :	Autism Asperger's-syndrome PDD-NOS autism-spectrum-disorder attention-deficit/hyperactivity-disorder impulsivity social-anxiety dopamine dopamine-transporter-gene genetics Tourette-syndrome
Index. décimale :	PER Périodiques
Résumé :	Background: Autism spectrum disorder (ASD) is associated with high rates of psychiatric disturbance to include attention-deficit/hyperactivity disorder (ADHD), tic disorder, and anxiety disorders. The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism located in the 3'-untranslated region of the dopamine transporter gene (DAT1) and the severity of these symptoms as well as the association between the DAT1 DdeI polymorphism and severity of tics. Methods: Parents (n = 62) and teachers (n = 57) completed a DSM-IV-referenced rating scale for 67 children with ASD. Results: According to parent ratings, children with the 10-10 repeat allele (versus a combined group of all other genotypes) exhibited less severe symptoms of hyperactivity and impulsivity as well as less severe language deficits. Teacher ratings indicated that social anxiety and tic symptoms were more severe for children with the 10-10 genotype versus all others. Exploratory analyses provided preliminary support for the notion that heterozygosity (9–10 repeat genotype) may be a risk/protective factor. There were no associations of tic severity with the DAT1 DdeI polymorphism. Conclusion: Collectively, these results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations. Nevertheless, replication with independent samples is necessary to confirm this preliminary finding.
En ligne :	http://dx.doi.org/10.1111/j.1469-7610.2008.01952.x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645

[article] Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur . - 2008 . - p.1331-1338.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1331-1338

Mots-clés :	Autism Asperger's-syndrome PDD-NOS autism-spectrum-disorder attention-deficit/hyperactivity-disorder impulsivity social-anxiety dopamine dopamine-transporter-gene genetics Tourette-syndrome
Index. décimale :	PER Périodiques
Résumé :	Background: Autism spectrum disorder (ASD) is associated with high rates of psychiatric disturbance to include attention-deficit/hyperactivity disorder (ADHD), tic disorder, and anxiety disorders. The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism located in the 3'-untranslated region of the dopamine transporter gene (DAT1) and the severity of these symptoms as well as the association between the DAT1 DdeI polymorphism and severity of tics. Methods: Parents (n = 62) and teachers (n = 57) completed a DSM-IV-referenced rating scale for 67 children with ASD. Results: According to parent ratings, children with the 10-10 repeat allele (versus a combined group of all other genotypes) exhibited less severe symptoms of hyperactivity and impulsivity as well as less severe language deficits. Teacher ratings indicated that social anxiety and tic symptoms were more severe for children with the 10-10 genotype versus all others. Exploratory analyses provided preliminary support for the notion that heterozygosity (9–10 repeat genotype) may be a risk/protective factor. There were no associations of tic severity with the DAT1 DdeI polymorphism. Conclusion: Collectively, these results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations. Nevertheless, replication with independent samples is necessary to confirm this preliminary finding.
En ligne :	http://dx.doi.org/10.1111/j.1469-7610.2008.01952.x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645