[article] 
inJournal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.67-74

Titre :	Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder
Type de document :	texte imprimé
Auteurs :	Jasmin ROOHI, Auteur ; Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Eli HATCHWELL, Auteur
Année de publication :	2009
Article en page(s) :	p.67-74
Langues :	Anglais (eng)
Mots-clés :	Autism Asperger’s-syndrome PDD-NOS Autism-spectrum-disorder Attention-deficit/hyperactivity-disorder Generalized-anxiety-disorder Monoamine-oxidase MAO-A Genetics
Index. décimale :	PER Périodiques
Résumé :	The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0600-8
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660

[article] Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder [texte imprimé] / Jasmin ROOHI, Auteur ; Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Eli HATCHWELL, Auteur . - 2009 . - p.67-74.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.67-74

Mots-clés :	Autism Asperger’s-syndrome PDD-NOS Autism-spectrum-disorder Attention-deficit/hyperactivity-disorder Generalized-anxiety-disorder Monoamine-oxidase MAO-A Genetics
Index. décimale :	PER Périodiques
Résumé :	The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0600-8
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660