[article]
| Titre : |
GABAa Receptor Downregulation in Brains of Subjects with Autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur |
| Année de publication : |
2009 |
| Article en page(s) : |
p.223-230 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
GABRA1 GABRA2 GABRA3 GABRB3 Autism Brain |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABAA receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann’s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABAA receptor subunit expression in the three brain areas. Our results demonstrate that GABAA receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-008-0646-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683 |
in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.223-230
[article] GABAa Receptor Downregulation in Brains of Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur . - 2009 . - p.223-230. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.223-230
| Mots-clés : |
GABRA1 GABRA2 GABRA3 GABRB3 Autism Brain |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABAA receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann’s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABAA receptor subunit expression in the three brain areas. Our results demonstrate that GABAA receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-008-0646-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683 |
|
GABAa Receptor Downregulation in Brains of Subjects with Autism in Journal of Autism and Developmental Disorders, 39-2 (February 2009)
