Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study / David PAGLIACCIO in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.254-264 Titre : Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : David PAGLIACCIO, Auteur ; Poornima KUMAR, Auteur ; Rahil A. KAMATH, Auteur ; Diego A. PIZZAGALLI, Auteur ; Randy P. AUERBACH, Auteur Article en page(s) : p.254-264 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Depression risk increases during adolescent development, and individual differences in neural sensitivity to peer feedback (rejection vs. acceptance) may be a key diathesis in understanding stress-related depression risk. Methods At baseline, adolescents (12-14 years old; N=124) completed clinical interviews and self-report symptom measures, and the Chatroom Task while MRI data were acquired. The majority of participants provided usable MRI data (N=90; 76% female), which included adolescents with no maternal depression history (low risk n=64) and those with a maternal depression history (high risk n=26). Whole-brain regression models probed group differences in neural sensitivity following peer feedback, and whole-brain linear mixed-effects models examined neural sensitivity to peer feedback by peer stress interactions relating to depression symptoms at up to nine longitudinal assessments over 2 years. Results Whole-brain cluster-corrected results indicated brain activation moderating the strong positive association between peer interpersonal stress and depression over time. This included activation in the anterior insula, cingulate, amygdala, and striatum during anticipation and receipt of feedback (i.e., rejection vs. acceptance). Moderation effects were stronger when examining peer interpersonal (vs. non-interpersonal) stress and in relation to depression (vs. social anxiety) symptoms. Conclusions Neural responses to peer feedback in key social and incentive processing brain regions may reflect core dispositional risk factors that interact with peer interpersonal stressors to predict adolescent depression symptom severity over time. En ligne : https://doi.org/10.1111/jcpp.13690 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study [Texte imprimé et/ou numérique] / David PAGLIACCIO, Auteur ; Poornima KUMAR, Auteur ; Rahil A. KAMATH, Auteur ; Diego A. PIZZAGALLI, Auteur ; Randy P. AUERBACH, Auteur . - p.254-264. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.254-264 Index. décimale : PER Périodiques Résumé : Background Depression risk increases during adolescent development, and individual differences in neural sensitivity to peer feedback (rejection vs. acceptance) may be a key diathesis in understanding stress-related depression risk. Methods At baseline, adolescents (12-14 years old; N=124) completed clinical interviews and self-report symptom measures, and the Chatroom Task while MRI data were acquired. The majority of participants provided usable MRI data (N=90; 76% female), which included adolescents with no maternal depression history (low risk n=64) and those with a maternal depression history (high risk n=26). Whole-brain regression models probed group differences in neural sensitivity following peer feedback, and whole-brain linear mixed-effects models examined neural sensitivity to peer feedback by peer stress interactions relating to depression symptoms at up to nine longitudinal assessments over 2 years. Results Whole-brain cluster-corrected results indicated brain activation moderating the strong positive association between peer interpersonal stress and depression over time. This included activation in the anterior insula, cingulate, amygdala, and striatum during anticipation and receipt of feedback (i.e., rejection vs. acceptance). Moderation effects were stronger when examining peer interpersonal (vs. non-interpersonal) stress and in relation to depression (vs. social anxiety) symptoms. Conclusions Neural responses to peer feedback in key social and incentive processing brain regions may reflect core dispositional risk factors that interact with peer interpersonal stressors to predict adolescent depression symptom severity over time. En ligne : https://doi.org/10.1111/jcpp.13690 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Stress exposure in at-risk, depressed, and suicidal adolescents / Diego A. PIZZAGALLI ; Randy P. AUERBACH in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.942-958 Titre : Stress exposure in at-risk, depressed, and suicidal adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Diego A. PIZZAGALLI, Auteur ; Randy P. AUERBACH, Auteur Article en page(s) : p.942-958 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Stress exposure contributes to the onset, maintenance, and recurrence of major depressive disorder (MDD) in adolescents. However, the precise stress facets (e.g. chronicity, domain) most strongly linked to outcomes at different stages along the depression severity continuum remain unclear. Across two studies, chronic and episodic stressors were comprehensively assessed among: (a) healthy youth with (High-Risk [HR]) and without (Low-Risk [LR]) a maternal history of MDD and (b) adolescents with current MDD and suicide ideation and healthy controls (HC). Method Study 1 included LR (n = 65) and HR (n = 22) 12- to 14-year-olds (49 females; 56.32%) with no lifetime history of mental disorders. Study 2 enrolled 87 mid-to-late adolescents (64 females; 73.56%), including 57 MDD youth from a short-term intensive treatment service and 30 HCs from the community. All depressed youth reported recent suicide ideation; some had no lifetime history suicide attempts (SI; n = 31) and others reported at least one past year attempt (SA; n = 26). The Life Events and Difficulties Schedule was used to capture stressor severity in both studies. Results We used multiple linear regression models that adjusted for demographic and clinical covariates. Being in the HR versus LR group was associated with more severe chronic (? = .22, CI95 = 0.01-0.42, p = .041), independent (? = .34, CI95 = 0.12-0.56, p = .003), and interpersonal (? = .23, CI95 = 0.004-0.45, p = .047) stress severity. By contrast, the MDD group reported significantly more severe chronic (? = .62, CI95 = 0.45-0.79, p <.001) and dependent (? = .41, CI95 = 0.21-0.61, p <.001) stress than the HC group, but not independent (p = .083) stress. Stress severity did not differ between recent attempters versus youth who reported suicide ideation alone (SA vs. SI contrast). However, the SA group reported a higher rate of targeted rejection events (RR = 3.53, CI95 = 1.17-10.70, p = .026). Conclusions Our findings clarify the stressor features that may most strongly contribute to adolescent depression and its clinical correlates at two important points along depression's clinical course. En ligne : https://doi.org/10.1111/jcpp.13935 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Stress exposure in at-risk, depressed, and suicidal adolescents [Texte imprimé et/ou numérique] / Diego A. PIZZAGALLI, Auteur ; Randy P. AUERBACH, Auteur . - p.942-958. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.942-958 Index. décimale : PER Périodiques Résumé : Background Stress exposure contributes to the onset, maintenance, and recurrence of major depressive disorder (MDD) in adolescents. However, the precise stress facets (e.g. chronicity, domain) most strongly linked to outcomes at different stages along the depression severity continuum remain unclear. Across two studies, chronic and episodic stressors were comprehensively assessed among: (a) healthy youth with (High-Risk [HR]) and without (Low-Risk [LR]) a maternal history of MDD and (b) adolescents with current MDD and suicide ideation and healthy controls (HC). Method Study 1 included LR (n = 65) and HR (n = 22) 12- to 14-year-olds (49 females; 56.32%) with no lifetime history of mental disorders. Study 2 enrolled 87 mid-to-late adolescents (64 females; 73.56%), including 57 MDD youth from a short-term intensive treatment service and 30 HCs from the community. All depressed youth reported recent suicide ideation; some had no lifetime history suicide attempts (SI; n = 31) and others reported at least one past year attempt (SA; n = 26). The Life Events and Difficulties Schedule was used to capture stressor severity in both studies. Results We used multiple linear regression models that adjusted for demographic and clinical covariates. Being in the HR versus LR group was associated with more severe chronic (? = .22, CI95 = 0.01-0.42, p = .041), independent (? = .34, CI95 = 0.12-0.56, p = .003), and interpersonal (? = .23, CI95 = 0.004-0.45, p = .047) stress severity. By contrast, the MDD group reported significantly more severe chronic (? = .62, CI95 = 0.45-0.79, p <.001) and dependent (? = .41, CI95 = 0.21-0.61, p <.001) stress than the HC group, but not independent (p = .083) stress. Stress severity did not differ between recent attempters versus youth who reported suicide ideation alone (SA vs. SI contrast). However, the SA group reported a higher rate of targeted rejection events (RR = 3.53, CI95 = 1.17-10.70, p = .026). Conclusions Our findings clarify the stressor features that may most strongly contribute to adolescent depression and its clinical correlates at two important points along depression's clinical course. En ligne : https://doi.org/10.1111/jcpp.13935 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

---

1 (1 - 2 / 2)