Increased resting-state thalamocortical functional connectivity in children and young adults with autism spectrum disorder / Quynh Trang Huong NGUYEN ; Dimitrios MYLONAS ; Susan L. SANTANGELO ; Dara S. MANOACH in Autism Research, 16-2 (February 2023)  

Public ISBD [article]  inAutism Research > 16-2 (February 2023) . - p.271-279 Titre : Increased resting-state thalamocortical functional connectivity in children and young adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Quynh Trang Huong NGUYEN, Auteur ; Dimitrios MYLONAS, Auteur ; Susan L. SANTANGELO, Auteur ; Dara S. MANOACH, Auteur Article en page(s) : p.271-279 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract There is converging evidence that abnormal thalamocortical interactions contribute to attention deficits and sensory sensitivities in autism spectrum disorder (ASD). However, previous functional MRI studies of thalamocortical connectivity in ASD have produced inconsistent findings in terms of both the direction (hyper vs. hypoconnectivity) and location of group differences. This may reflect, in part, the confounding effects of head motion during scans. In the present study, we investigated resting-state thalamocortical functional connectivity in 8-25â€year-olds with ASD and their typically developing (TD) peers. We used pre-scan training, on-line motion correction, and rigorous data quality assurance protocols to minimize motion confounds. ASD participants showed increased thalamic connectivity with temporal cortex relative to TD. Both groups showed similar age-related decreases in thalamic connectivity with occipital cortex, consistent with a process of circuit refinement. Findings of thalamocortical hyperconnectivity in ASD are consistent with other evidence that decreased thalamic inhibition leads to increase and less filtered sensory information reaching the cortex where it disrupts attention and contributes to sensory sensitivity. This literature motivates studies of mechanisms, functional consequences, and treatment of thalamocortical circuit dysfunction in ASD. En ligne : https://doi.org/10.1002/aur.2875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 [article] Increased resting-state thalamocortical functional connectivity in children and young adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Quynh Trang Huong NGUYEN, Auteur ; Dimitrios MYLONAS, Auteur ; Susan L. SANTANGELO, Auteur ; Dara S. MANOACH, Auteur . - p.271-279. Langues : Anglais (eng) in Autism Research > 16-2 (February 2023) . - p.271-279 Index. décimale : PER Périodiques Résumé : Abstract There is converging evidence that abnormal thalamocortical interactions contribute to attention deficits and sensory sensitivities in autism spectrum disorder (ASD). However, previous functional MRI studies of thalamocortical connectivity in ASD have produced inconsistent findings in terms of both the direction (hyper vs. hypoconnectivity) and location of group differences. This may reflect, in part, the confounding effects of head motion during scans. In the present study, we investigated resting-state thalamocortical functional connectivity in 8-25â€year-olds with ASD and their typically developing (TD) peers. We used pre-scan training, on-line motion correction, and rigorous data quality assurance protocols to minimize motion confounds. ASD participants showed increased thalamic connectivity with temporal cortex relative to TD. Both groups showed similar age-related decreases in thalamic connectivity with occipital cortex, consistent with a process of circuit refinement. Findings of thalamocortical hyperconnectivity in ASD are consistent with other evidence that decreased thalamic inhibition leads to increase and less filtered sensory information reaching the cortex where it disrupts attention and contributes to sensory sensitivity. This literature motivates studies of mechanisms, functional consequences, and treatment of thalamocortical circuit dysfunction in ASD. En ligne : https://doi.org/10.1002/aur.2875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495

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