Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder / Danella M. HAFEMAN in Journal of Child Psychology and Psychiatry, 64-10 (October 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Titre : Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder Type de document : texte imprimé Auteurs : Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David A. AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur Article en page(s) : p.1492-1500 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5 years old) and then approximately every 2 years for a mean of 10.6 years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder [texte imprimé] / Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David A. AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur . - p.1492-1500. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5 years old) and then approximately every 2 years for a mean of 10.6 years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Research Review: A systematic review and meta-analysis of infant and toddler temperament as predictors of childhood attention-deficit/hyperactivity disorder / Heather M. JOSEPH in Journal of Child Psychology and Psychiatry, 64-5 (May 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-5 (May 2023) . - p.715-735 Titre : Research Review: A systematic review and meta-analysis of infant and toddler temperament as predictors of childhood attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Heather M. JOSEPH, Auteur ; Nicole E. LORENZO, Auteur ; Nadiyah FISHER, Auteur ; Danielle R. NOVICK, Auteur ; Cassandra GIBSON, Auteur ; Scott D. ROTHENBERGER, Auteur ; Jill E. FOUST, Auteur ; Andrea CHRONIS-TUSCANO, Auteur Article en page(s) : p.715-735 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with onset as early as preschool and impairment across the lifespan. Temperament factors, specifically those that theoretically map onto ADHD symptoms, may be early markers of risk for developing later childhood ADHD that could be identifiable in infancy or toddlerhood. This meta-analysis examined the associations between these early temperamental factors and later symptoms and diagnosis of ADHD and mapped early temperament constructs onto the three ADHD symptom dimensions. Methods A systemic review of the literature was conducted to identify prospective longitudinal studies that included theoretically relevant temperament constructs (sustained attention, activity level, inhibition, and negative emotionality) examined from birth to 36 months old and ADHD (symptoms or diagnosis) in preschool or childhood. The association between each temperament construct and ADHD outcomes was examined using pooled standardized estimates in meta-analyses. Results Forty-eight articles (n = 112,716 infants/toddlers) prospectively examined temperament and the relation to childhood ADHD symptoms or diagnosis. Activity level (k = 18) in infancy and toddlerhood was moderately associated with childhood ADHD (r = .39, CI = 0.27, 0.51, p En ligne : https://doi.org/10.1111/jcpp.13753 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Research Review: A systematic review and meta-analysis of infant and toddler temperament as predictors of childhood attention-deficit/hyperactivity disorder [texte imprimé] / Heather M. JOSEPH, Auteur ; Nicole E. LORENZO, Auteur ; Nadiyah FISHER, Auteur ; Danielle R. NOVICK, Auteur ; Cassandra GIBSON, Auteur ; Scott D. ROTHENBERGER, Auteur ; Jill E. FOUST, Auteur ; Andrea CHRONIS-TUSCANO, Auteur . - p.715-735. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-5 (May 2023) . - p.715-735 Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with onset as early as preschool and impairment across the lifespan. Temperament factors, specifically those that theoretically map onto ADHD symptoms, may be early markers of risk for developing later childhood ADHD that could be identifiable in infancy or toddlerhood. This meta-analysis examined the associations between these early temperamental factors and later symptoms and diagnosis of ADHD and mapped early temperament constructs onto the three ADHD symptom dimensions. Methods A systemic review of the literature was conducted to identify prospective longitudinal studies that included theoretically relevant temperament constructs (sustained attention, activity level, inhibition, and negative emotionality) examined from birth to 36 months old and ADHD (symptoms or diagnosis) in preschool or childhood. The association between each temperament construct and ADHD outcomes was examined using pooled standardized estimates in meta-analyses. Results Forty-eight articles (n = 112,716 infants/toddlers) prospectively examined temperament and the relation to childhood ADHD symptoms or diagnosis. Activity level (k = 18) in infancy and toddlerhood was moderately associated with childhood ADHD (r = .39, CI = 0.27, 0.51, p En ligne : https://doi.org/10.1111/jcpp.13753 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS / Frances L. WANG in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.704-718 Titre : Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS Type de document : texte imprimé Auteurs : Frances L. WANG, Auteur ; Shirley DUONG, Auteur ; Heather M. JOSEPH, Auteur ; Traci M. KENNEDY, Auteur ; Catharina HARTMAN, Auteur Article en page(s) : p.704-718 Langues : Anglais (eng) Mots-clés : Externalizing  internalizing  polygenic risk score  temperament multi-trajectory groups Index. décimale : PER Périodiques Résumé : It is well-established that adolescents’ temperament trajectories predict future psychopathology. Less well understood is how temperament traits co-develop from adolescence to young adulthood. We characterized how youths’ trajectories of effortful control, frustration, affiliation, and shyness formed multi-trajectory groups and examined their associations with adulthood psychopathology and polygenic risk scores (PRS). Participants were drawn from a larger longitudinal cohort (N = 1412). Effortful control, frustration, affiliation, and shyness were measured four times from ages 10-23. Adulthood internalizing and externalizing problems were measured at ages 24–27. PRS for externalizing problems and major depressive disorder were calculated. Group-based multi-trajectory analyses showed that a five-group model fit best, including “high-risk” on all temperament traits, “undercontrolled” and exuberant, “low-risk” on all traits, “overcontrolled” and inhibited, and “low affiliation” groups that differed on both the levels and slopes of temperament traits over time. The undercontrolled group showed the highest, and overcontrolled the lowest, externalizing PRS scores. The high-risk group showed heightened scores on the depression PRS. We found specific linkages between the high-risk group and withdrawn/depressed symptoms and the high-risk and undercontrolled groups with externalizing problems. Findings shed light on developmental patterns of temperament in adolescence-to-adulthood and unique combinations of temperament trajectories with specific linkages to etiologic factors and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579425100680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS [texte imprimé] / Frances L. WANG, Auteur ; Shirley DUONG, Auteur ; Heather M. JOSEPH, Auteur ; Traci M. KENNEDY, Auteur ; Catharina HARTMAN, Auteur . - p.704-718. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.704-718 Mots-clés : Externalizing  internalizing  polygenic risk score  temperament multi-trajectory groups Index. décimale : PER Périodiques Résumé : It is well-established that adolescents’ temperament trajectories predict future psychopathology. Less well understood is how temperament traits co-develop from adolescence to young adulthood. We characterized how youths’ trajectories of effortful control, frustration, affiliation, and shyness formed multi-trajectory groups and examined their associations with adulthood psychopathology and polygenic risk scores (PRS). Participants were drawn from a larger longitudinal cohort (N = 1412). Effortful control, frustration, affiliation, and shyness were measured four times from ages 10-23. Adulthood internalizing and externalizing problems were measured at ages 24–27. PRS for externalizing problems and major depressive disorder were calculated. Group-based multi-trajectory analyses showed that a five-group model fit best, including “high-risk” on all temperament traits, “undercontrolled” and exuberant, “low-risk” on all traits, “overcontrolled” and inhibited, and “low affiliation” groups that differed on both the levels and slopes of temperament traits over time. The undercontrolled group showed the highest, and overcontrolled the lowest, externalizing PRS scores. The high-risk group showed heightened scores on the depression PRS. We found specific linkages between the high-risk group and withdrawn/depressed symptoms and the high-risk and undercontrolled groups with externalizing problems. Findings shed light on developmental patterns of temperament in adolescence-to-adulthood and unique combinations of temperament trajectories with specific linkages to etiologic factors and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579425100680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

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