An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2198-2210 Titre : An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIRKOVSKI, Auteur ; Mervyn SINGH, Auteur ; Thijs DHOLLANDER, Auteur ; Ian FUELSCHER, Auteur ; Christian HYDE, Auteur ; Natalia ALBEIN-URIOS, Auteur ; Peter H. DONALDSON, Auteur ; Peter G. ENTICOTT, Auteur Article en page(s) : p.2198-2210 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19?+?7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87?+?3.15 years) ASD cohort. Among the oldest ASD cohort (17.07?+?3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. En ligne : https://doi.org/10.1007/s10803-023-05980-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure [Texte imprimé et/ou numérique] / Melissa KIRKOVSKI, Auteur ; Mervyn SINGH, Auteur ; Thijs DHOLLANDER, Auteur ; Ian FUELSCHER, Auteur ; Christian HYDE, Auteur ; Natalia ALBEIN-URIOS, Auteur ; Peter H. DONALDSON, Auteur ; Peter G. ENTICOTT, Auteur . - p.2198-2210. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2198-2210 Index. décimale : PER Périodiques Résumé : Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19?+?7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87?+?3.15 years) ASD cohort. Among the oldest ASD cohort (17.07?+?3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. En ligne : https://doi.org/10.1007/s10803-023-05980-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1 / Anita K. CHISHOLM in Journal of Autism and Developmental Disorders, 53-7 (July 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2835-2850 Titre : Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1 Type de document : Texte imprimé et/ou numérique Auteurs : Anita K. CHISHOLM, Auteur ; Francesca LAMI, Auteur ; Kristina M. HAEBICH, Auteur ; Alex URE, Auteur ; Amanda BRIGNELL, Auteur ; Tiba MALOOF, Auteur ; Natalie A. PRIDE, Auteur ; Karin S. WALSH, Auteur ; Alice MAIER, Auteur ; Melissa ROUEL, Auteur ; Yael GRANADER, Auteur ; Belinda BARTON, Auteur ; Hayley DARKE, Auteur ; Ian FUELSCHER, Auteur ; Gabriel DABSCHECK, Auteur ; Vicki A. ANDERSON, Auteur ; Katrina WILLIAMS, Auteur ; Kathryn N. NORTH, Auteur ; Jonathan M. PAYNE, Auteur Article en page(s) : p.2835-2850 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ? 60). Thirty-four males and 28 females (3-16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1. En ligne : https://doi.org/10.1007/s10803-022-05571-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1 [Texte imprimé et/ou numérique] / Anita K. CHISHOLM, Auteur ; Francesca LAMI, Auteur ; Kristina M. HAEBICH, Auteur ; Alex URE, Auteur ; Amanda BRIGNELL, Auteur ; Tiba MALOOF, Auteur ; Natalie A. PRIDE, Auteur ; Karin S. WALSH, Auteur ; Alice MAIER, Auteur ; Melissa ROUEL, Auteur ; Yael GRANADER, Auteur ; Belinda BARTON, Auteur ; Hayley DARKE, Auteur ; Ian FUELSCHER, Auteur ; Gabriel DABSCHECK, Auteur ; Vicki A. ANDERSON, Auteur ; Katrina WILLIAMS, Auteur ; Kathryn N. NORTH, Auteur ; Jonathan M. PAYNE, Auteur . - p.2835-2850. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2835-2850 Index. décimale : PER Périodiques Résumé : This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ? 60). Thirty-four males and 28 females (3-16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1. En ligne : https://doi.org/10.1007/s10803-022-05571-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

---

1 (1 - 2 / 2)