Report from a randomized control trial: improved alignment between circadian biology and sleep-wake behavior as a mechanism of depression symptom improvement in evening-type adolescents with depressive symptoms / Adriane SOEHNER ; Emily DOLSEN ; Lulu DONG ; Allison G. HARVEY in Journal of Child Psychology and Psychiatry, 64-12 (December 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1652-1664 Titre : Report from a randomized control trial: improved alignment between circadian biology and sleep-wake behavior as a mechanism of depression symptom improvement in evening-type adolescents with depressive symptoms Type de document : texte imprimé Auteurs : Adriane SOEHNER, Auteur ; Emily DOLSEN, Auteur ; Lulu DONG, Auteur ; Allison G. HARVEY, Auteur Article en page(s) : p.1652-1664 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Study objectives An evening circadian preference is common among adolescents. It is characterized by a behavioral predilection for later sleep and wake timing and is associated with higher rates of Major Depressive Disorder (MDD). The present study aims to (a) test the effectiveness of a cognitive behavioral sleep intervention (Transdiagnostic Sleep and Circadian Intervention; TranS-C) in a sample of adolescents with an evening circadian preference and clinically significant depressive symptoms and (b) evaluate improved alignment between circadian biology and sleep-wake behavior as a potential mechanism in the relationship between sleep and depression symptom improvement. Methods Adolescents with an evening circadian preference and clinically significant depressive symptoms were randomized to receive TranS-C (n=24) or a psychoeducation condition (PE; n=18). Alignment between circadian biology and sleep-wake behavior was measured using objective biological measurement. Measures of sleep and circadian rhythm were taken at pre- and posttreatment, and depression symptoms were measured at pre- and posttreatment and 6- and 12-month follow-up. Results Mixed effects modeling revealed that compared with an active control condition, TranS-C resulted in a significant reduction in MDD severity at 12-month follow-up. A MacArthur mediation analysis conducted to explore alignment between circadian biology and sleep-wake behavior as a mediator of depression severity reduction through 12-month follow-up revealed a significant interaction between change in alignment between circadian biology and sleep-wake behavior and treatment arm, indicating that improved alignment between circadian biology and sleep-wake behavior at posttreatment was associated with improvements in depression outcomes at 12-month follow-up under the treatment condition. Conclusions These results provide novel evidence for improved alignment between circadian biology and sleep-wake behavior as a specific mechanism of depression improvement, provide key clues into the complex relationship between sleep and depression, and have significant clinical implications for adolescents with depression. En ligne : https://doi.org/10.1111/jcpp.13880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Report from a randomized control trial: improved alignment between circadian biology and sleep-wake behavior as a mechanism of depression symptom improvement in evening-type adolescents with depressive symptoms [texte imprimé] / Adriane SOEHNER, Auteur ; Emily DOLSEN, Auteur ; Lulu DONG, Auteur ; Allison G. HARVEY, Auteur . - p.1652-1664. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1652-1664 Index. décimale : PER Périodiques Résumé : Study objectives An evening circadian preference is common among adolescents. It is characterized by a behavioral predilection for later sleep and wake timing and is associated with higher rates of Major Depressive Disorder (MDD). The present study aims to (a) test the effectiveness of a cognitive behavioral sleep intervention (Transdiagnostic Sleep and Circadian Intervention; TranS-C) in a sample of adolescents with an evening circadian preference and clinically significant depressive symptoms and (b) evaluate improved alignment between circadian biology and sleep-wake behavior as a potential mechanism in the relationship between sleep and depression symptom improvement. Methods Adolescents with an evening circadian preference and clinically significant depressive symptoms were randomized to receive TranS-C (n=24) or a psychoeducation condition (PE; n=18). Alignment between circadian biology and sleep-wake behavior was measured using objective biological measurement. Measures of sleep and circadian rhythm were taken at pre- and posttreatment, and depression symptoms were measured at pre- and posttreatment and 6- and 12-month follow-up. Results Mixed effects modeling revealed that compared with an active control condition, TranS-C resulted in a significant reduction in MDD severity at 12-month follow-up. A MacArthur mediation analysis conducted to explore alignment between circadian biology and sleep-wake behavior as a mediator of depression severity reduction through 12-month follow-up revealed a significant interaction between change in alignment between circadian biology and sleep-wake behavior and treatment arm, indicating that improved alignment between circadian biology and sleep-wake behavior at posttreatment was associated with improvements in depression outcomes at 12-month follow-up under the treatment condition. Conclusions These results provide novel evidence for improved alignment between circadian biology and sleep-wake behavior as a specific mechanism of depression improvement, provide key clues into the complex relationship between sleep and depression, and have significant clinical implications for adolescents with depression. En ligne : https://doi.org/10.1111/jcpp.13880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Risk factors associated with longitudinal trajectories of mania symptoms in youth / Jasmin DÖNICKE in Development and Psychopathology, 38-4 (October 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-4 (October 2026) . - p.1940-1951 Titre : Risk factors associated with longitudinal trajectories of mania symptoms in youth Type de document : texte imprimé Auteurs : Jasmin DÖNICKE, Auteur ; Rebecca COOPER, Auteur ; Adriane SOEHNER, Auteur ; Maria JALBRZIKOWSKI, Auteur Article en page(s) : p.1940-1951 Langues : Anglais (eng) Mots-clés : adolescents  epidemiology  longitudinal study  mania trajectories  risk factors Index. décimale : PER Périodiques Résumé : Mania symptoms in youth predict poor long-term mental health outcomes, yet their developmental trajectories and associated risk factors remain unclear. Leveraging data from the Adolescent Brain Cognitive Development Study (N = 10,474; 9–10 years at baseline; 48% female, 65% white), we used latent growth mixture models to identify trajectories of mania symptoms across two years in early adolescence. We used multinomial logistic regressions to examine associations between trajectories and risk factors across mental and physical health, cognition, and family/environmental domains. We identified three trajectories: Low (58%), Moderate (32%), and High/Variable Mania Symptoms (10%). All mental health symptoms (depression, attention deficit hyperactivity disorder, conduct and oppositional defiant disorders and anxiety), two physical health factors (sleep disturbances, irritable bowel syndrome symptoms), one cognitive factor (verbal learning impairment), and three family/environmental factors (trauma, parent- and youth-reported family conflict) significantly differentiated between all three trajectories, reflecting incremental increases in risk factor severity with increasing mania symptoms. Other physical, cognitive, family and environmental factors were also associated with more severe mania symptom trajectories. More severe mania symptom trajectories in early adolescence are associated with multiple mental, physical, cognitive, family and environmental risk factors, underscoring the need for comprehensive risk prediction approaches in youth. En ligne : https://dx.doi.org/10.1017/S0954579426101606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Risk factors associated with longitudinal trajectories of mania symptoms in youth [texte imprimé] / Jasmin DÖNICKE, Auteur ; Rebecca COOPER, Auteur ; Adriane SOEHNER, Auteur ; Maria JALBRZIKOWSKI, Auteur . - p.1940-1951. Langues : Anglais (eng) in Development and Psychopathology > 38-4 (October 2026) . - p.1940-1951 Mots-clés : adolescents  epidemiology  longitudinal study  mania trajectories  risk factors Index. décimale : PER Périodiques Résumé : Mania symptoms in youth predict poor long-term mental health outcomes, yet their developmental trajectories and associated risk factors remain unclear. Leveraging data from the Adolescent Brain Cognitive Development Study (N = 10,474; 9–10 years at baseline; 48% female, 65% white), we used latent growth mixture models to identify trajectories of mania symptoms across two years in early adolescence. We used multinomial logistic regressions to examine associations between trajectories and risk factors across mental and physical health, cognition, and family/environmental domains. We identified three trajectories: Low (58%), Moderate (32%), and High/Variable Mania Symptoms (10%). All mental health symptoms (depression, attention deficit hyperactivity disorder, conduct and oppositional defiant disorders and anxiety), two physical health factors (sleep disturbances, irritable bowel syndrome symptoms), one cognitive factor (verbal learning impairment), and three family/environmental factors (trauma, parent- and youth-reported family conflict) significantly differentiated between all three trajectories, reflecting incremental increases in risk factor severity with increasing mania symptoms. Other physical, cognitive, family and environmental factors were also associated with more severe mania symptom trajectories. More severe mania symptom trajectories in early adolescence are associated with multiple mental, physical, cognitive, family and environmental risk factors, underscoring the need for comprehensive risk prediction approaches in youth. En ligne : https://dx.doi.org/10.1017/S0954579426101606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

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