The interaction between polygenic risk and environmental influences: A direct test of the 3P model of insomnia in adolescents / Nicola L. BARCLAY ; Alice M. GREGORY in Journal of Child Psychology and Psychiatry, 65-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.308-315 Titre : The interaction between polygenic risk and environmental influences: A direct test of the 3P model of insomnia in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Nicola L. BARCLAY, Auteur ; Alice M. GREGORY, Auteur Article en page(s) : p.308-315 Index. décimale : PER Périodiques Résumé : Background Stress is a universal phenomenon and one of the most common precipitants of insomnia. However, not everyone develops insomnia after experiencing a stressful life event. This study aims to test aspects of Spielman's ?3P model of insomnia? (during adolescence) by exploring the extent to which: (a) insomnia symptoms are predicted by polygenic scores (PGS); (b) life events predict insomnia symptoms; (c) the interaction between PGS and life events contribute to the prediction of insomnia symptoms; (d) gene?environment interaction effects remain after controlling for sex. Methods The sample comprised 4,629 twins aged 16 from the Twin Early Development Study who reported on their insomnia symptoms and life events. PGS for insomnia were calculated. In order to test the main hypothesis of this study (a significant interaction between PGS and negative life events), we fitted a series of mixed effect regressions. Results The best fit was provided by the model including sex, PGS for insomnia, negative life events, and their interactions (AIC?=?26,158.7). Our results show that the association between insomnia symptoms and negative life events is stronger for those with a higher genetic risk for insomnia. Conclusions This work sheds light on the complex relationship between genetic and environmental factors implicated for insomnia. This study has tested for the first time the interaction between genetic predisposition (PGS) for insomnia and environmental stressors (negative life events) in adolescents. This work represents a direct test of components of Spielman's 3P model for insomnia which is supported by our results. En ligne : https://doi.org/10.1111/jcpp.13895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] The interaction between polygenic risk and environmental influences: A direct test of the 3P model of insomnia in adolescents [Texte imprimé et/ou numérique] / Nicola L. BARCLAY, Auteur ; Alice M. GREGORY, Auteur . - p.308-315. in Journal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.308-315 Index. décimale : PER Périodiques Résumé : Background Stress is a universal phenomenon and one of the most common precipitants of insomnia. However, not everyone develops insomnia after experiencing a stressful life event. This study aims to test aspects of Spielman's ?3P model of insomnia? (during adolescence) by exploring the extent to which: (a) insomnia symptoms are predicted by polygenic scores (PGS); (b) life events predict insomnia symptoms; (c) the interaction between PGS and life events contribute to the prediction of insomnia symptoms; (d) gene?environment interaction effects remain after controlling for sex. Methods The sample comprised 4,629 twins aged 16 from the Twin Early Development Study who reported on their insomnia symptoms and life events. PGS for insomnia were calculated. In order to test the main hypothesis of this study (a significant interaction between PGS and negative life events), we fitted a series of mixed effect regressions. Results The best fit was provided by the model including sex, PGS for insomnia, negative life events, and their interactions (AIC?=?26,158.7). Our results show that the association between insomnia symptoms and negative life events is stronger for those with a higher genetic risk for insomnia. Conclusions This work sheds light on the complex relationship between genetic and environmental factors implicated for insomnia. This study has tested for the first time the interaction between genetic predisposition (PGS) for insomnia and environmental stressors (negative life events) in adolescents. This work represents a direct test of components of Spielman's 3P model for insomnia which is supported by our results. En ligne : https://doi.org/10.1111/jcpp.13895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

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