Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population / Desana KOCEVSKA in Journal of Child Psychology and Psychiatry, 65-5 (May 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.710-719 Titre : Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Desana KOCEVSKA, Auteur ; Katerina TRAJANOSKA, Auteur ; Rosa H. MULDER, Auteur ; M. Elisabeth KOOPMAN-VERHOEFF, Auteur ; Annemarie I. LUIK, Auteur ; Henning TIEMEIER, Auteur ; Eus J.W. VAN SOMEREN, Auteur Article en page(s) : p.710-719 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Twin studies show moderate heritability of sleep traits: 40% for insomnia symptoms and 46% for sleep duration. Genome-wide association studies (GWAS) have identified genetic variants involved in insomnia and sleep duration in adults, but it is unknown whether these variants affect sleep during early development. We assessed whether polygenic risk scores for insomnia (PRS-I) and sleep duration (PRS-SD) affect sleep throughout early childhood to adolescence. Methods We included 2,458 children of European ancestry (51% girls). Insomnia-related items of the Child Behavior Checklist were reported by mothers at child's age 1.5, 3, and 6?years. At 10-15?years, the Sleep Disturbance Scale for Children and actigraphy were assessed in a subsample (N = 975). Standardized PRS-I and PRS-SD (higher scores indicate genetic susceptibility for insomnia and longer sleep duration, respectively) were computed at multiple p-value thresholds based on largest GWAS to date. Results Children with higher PRS-I had more insomnia-related sleep problems between 1.5 and 15?years (BPRS-I < 0.001 = .09, 95% CI: 0.05; 0.14). PRS-SD was not associated with mother-reported sleep problems. A higher PRS-SD was in turn associated with longer actigraphically estimated sleep duration (BPRS-SD < 5e08 = .05, 95% CI: 0.001; 0.09) and more wake after sleep onset (BPRS-SD < 0.005 = .25, 95% CI: 0.04; 0.47) at 10-15?years, but these associations did not survive multiple testing correction. Conclusions Children who are genetically predisposed to insomnia have more insomnia-like sleep problems, whereas those who are genetically predisposed to longer sleep have longer sleep duration, but are also more awake during the night in adolescence. This indicates that polygenic risk for sleep traits, based on GWAS in adults, affects sleep already in children. En ligne : https://doi.org/10.1111/jcpp.13899 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population [Texte imprimé et/ou numérique] / Desana KOCEVSKA, Auteur ; Katerina TRAJANOSKA, Auteur ; Rosa H. MULDER, Auteur ; M. Elisabeth KOOPMAN-VERHOEFF, Auteur ; Annemarie I. LUIK, Auteur ; Henning TIEMEIER, Auteur ; Eus J.W. VAN SOMEREN, Auteur . - p.710-719. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.710-719 Index. décimale : PER Périodiques Résumé : Background Twin studies show moderate heritability of sleep traits: 40% for insomnia symptoms and 46% for sleep duration. Genome-wide association studies (GWAS) have identified genetic variants involved in insomnia and sleep duration in adults, but it is unknown whether these variants affect sleep during early development. We assessed whether polygenic risk scores for insomnia (PRS-I) and sleep duration (PRS-SD) affect sleep throughout early childhood to adolescence. Methods We included 2,458 children of European ancestry (51% girls). Insomnia-related items of the Child Behavior Checklist were reported by mothers at child's age 1.5, 3, and 6?years. At 10-15?years, the Sleep Disturbance Scale for Children and actigraphy were assessed in a subsample (N = 975). Standardized PRS-I and PRS-SD (higher scores indicate genetic susceptibility for insomnia and longer sleep duration, respectively) were computed at multiple p-value thresholds based on largest GWAS to date. Results Children with higher PRS-I had more insomnia-related sleep problems between 1.5 and 15?years (BPRS-I < 0.001 = .09, 95% CI: 0.05; 0.14). PRS-SD was not associated with mother-reported sleep problems. A higher PRS-SD was in turn associated with longer actigraphically estimated sleep duration (BPRS-SD < 5e08 = .05, 95% CI: 0.001; 0.09) and more wake after sleep onset (BPRS-SD < 0.005 = .25, 95% CI: 0.04; 0.47) at 10-15?years, but these associations did not survive multiple testing correction. Conclusions Children who are genetically predisposed to insomnia have more insomnia-like sleep problems, whereas those who are genetically predisposed to longer sleep have longer sleep duration, but are also more awake during the night in adolescence. This indicates that polygenic risk for sleep traits, based on GWAS in adults, affects sleep already in children. En ligne : https://doi.org/10.1111/jcpp.13899 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

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