Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity / Sohair SALEM in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2266-2273 Titre : Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity Type de document : Texte imprimé et/ou numérique Auteurs : Sohair SALEM, Auteur ; Engy ASHAAT, Auteur Article en page(s) : p.2266-2273 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001). En ligne : https://doi.org/10.1007/s10803-023-05965-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity [Texte imprimé et/ou numérique] / Sohair SALEM, Auteur ; Engy ASHAAT, Auteur . - p.2266-2273. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2266-2273 Index. décimale : PER Périodiques Résumé : Autism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001). En ligne : https://doi.org/10.1007/s10803-023-05965-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

---

1 (1 - 1 / 1)