[article]
| Titre : |
A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Kensuke NOMURA, Auteur ; Kenji SANADA, Auteur ; Katsuma MIYAHO, Auteur ; Chiharu ISHII, Auteur ; Shinji FUKUDA, Auteur ; Chiaki IWAMOTO, Auteur ; Minori NARAOKA, Auteur ; Shintaro YONEDA, Auteur ; Masahiro IMAFUKU, Auteur ; Juntaro MATSUZAKI, Auteur ; Yoshimasa SAITO, Auteur ; Masaru MIMURA, Auteur ; Taishiro KISHIMOTO, Auteur |
| Article en page(s) : |
p.1184-1195 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Previous research has shown a significant link between gut microbiota in children with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). However, much remains unknown because of the heterogeneity of disorders and the potential confounders such as dietary patterns and control group variations. Methods Children aged 6-12?years who had been clinically diagnosed with ASD and/or ADHD, their unaffected neurotypical siblings, and non-related neurotypical volunteers were recruited cross-sectionally. The ASD diagnosis was confirmed using the Autism Diagnostic Observation Schedule-2 (ADOS-2) in all patients, including those with ADHD. Standardized DNA extraction and sequencing methods were used to compare gut microbial alpha-diversity among the groups. Dietary diversity was calculated from a standardized dietary questionnaire form. We compared the difference in gut microbiome between patients with ASD and/or ADHD with neurotypical siblings and non-related neurotypical controls. Results Ninety-eight subjects were included in the study (18 with ASD, 19 with ADHD, 20 with both ASD and ADHD, 13 neurotypical siblings, and 28 non-related neurotypical controls). The alpha-diversity indices, such as Chao 1 and Shannon index, showed a significant difference between the groups in a Linear mixed-effect model (F(4, 93) = 4.539, p = .02), (F(4, 93) = 3.185, p = .017), respectively. In a post-hoc pairwise comparison, patients with ASD had lower alpha-diversity compared with non-related controls after Bonferroni correction. Dietary diversity shown in Shannon index did not differ among the groups (F(4, 84) = 1.494, p = .211). Conclusions Our study indicates disorder-specific microbiome differences in patients with ASD. In future research on gut microbiota in neurodevelopmental disorders, it is necessary to consider the impact of ASD and ADHD co-occurrence, and strictly control for background information such as diet, to elucidate the gut-microbiota interaction in ASD and ADHD for exploring the potential of therapeutic interventions. |
| En ligne : |
https://doi.org/10.1111/jcpp.13962 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 |
in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1184-1195
[article] A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study [Texte imprimé et/ou numérique] / Kensuke NOMURA, Auteur ; Kenji SANADA, Auteur ; Katsuma MIYAHO, Auteur ; Chiharu ISHII, Auteur ; Shinji FUKUDA, Auteur ; Chiaki IWAMOTO, Auteur ; Minori NARAOKA, Auteur ; Shintaro YONEDA, Auteur ; Masahiro IMAFUKU, Auteur ; Juntaro MATSUZAKI, Auteur ; Yoshimasa SAITO, Auteur ; Masaru MIMURA, Auteur ; Taishiro KISHIMOTO, Auteur . - p.1184-1195. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1184-1195
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Previous research has shown a significant link between gut microbiota in children with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). However, much remains unknown because of the heterogeneity of disorders and the potential confounders such as dietary patterns and control group variations. Methods Children aged 6-12?years who had been clinically diagnosed with ASD and/or ADHD, their unaffected neurotypical siblings, and non-related neurotypical volunteers were recruited cross-sectionally. The ASD diagnosis was confirmed using the Autism Diagnostic Observation Schedule-2 (ADOS-2) in all patients, including those with ADHD. Standardized DNA extraction and sequencing methods were used to compare gut microbial alpha-diversity among the groups. Dietary diversity was calculated from a standardized dietary questionnaire form. We compared the difference in gut microbiome between patients with ASD and/or ADHD with neurotypical siblings and non-related neurotypical controls. Results Ninety-eight subjects were included in the study (18 with ASD, 19 with ADHD, 20 with both ASD and ADHD, 13 neurotypical siblings, and 28 non-related neurotypical controls). The alpha-diversity indices, such as Chao 1 and Shannon index, showed a significant difference between the groups in a Linear mixed-effect model (F(4, 93) = 4.539, p = .02), (F(4, 93) = 3.185, p = .017), respectively. In a post-hoc pairwise comparison, patients with ASD had lower alpha-diversity compared with non-related controls after Bonferroni correction. Dietary diversity shown in Shannon index did not differ among the groups (F(4, 84) = 1.494, p = .211). Conclusions Our study indicates disorder-specific microbiome differences in patients with ASD. In future research on gut microbiota in neurodevelopmental disorders, it is necessary to consider the impact of ASD and ADHD co-occurrence, and strictly control for background information such as diet, to elucidate the gut-microbiota interaction in ASD and ADHD for exploring the potential of therapeutic interventions. |
| En ligne : |
https://doi.org/10.1111/jcpp.13962 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 |
|
Faire une suggestion Affiner la rechercheA comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study / Kensuke NOMURA ; Kenji SANADA ; Katsuma MIYAHO ; Chiharu ISHII ; Shinji FUKUDA ; Chiaki IWAMOTO ; Minori NARAOKA ; Shintaro YONEDA ; Masahiro IMAFUKU ; Juntaro MATSUZAKI ; Yoshimasa SAITO ; Masaru MIMURA ; Taishiro KISHIMOTO in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)
