Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children / Wolff SCHLOTZ in Journal of Child Psychology and Psychiatry, 49-11 (November 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1228-1236 Titre : Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children Type de document : Texte imprimé et/ou numérique Auteurs : Wolff SCHLOTZ, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur Année de publication : 2008 Article en page(s) : p.1228-1236 Langues : Anglais (eng) Mots-clés : Fetal-growth temperament effortful-control behavioural-problems hyperactivity birth-weight Index. décimale : PER Périodiques Résumé : Background: Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on behaviour later in life. However, no study so far has examined effects on temperament and potential developmental pathways. Temperamental traits may be particularly susceptible to neurodevelopmental alterations, and they are linked to behavioural problems. Therefore, we tested for associations of fetal growth with behavioural problems in children and tested if temperament mediated such effects. Methods: One hundred and thirty-nine mother–child pairs were recruited in early pregnancy. Weight, head circumference and gestational age were measured at birth, and the mother reported on their child's behavioural problems and temperament at age 7 to 9 years. Results: Birth weight and head circumference at birth adjusted for gestational age (i.e., fetal growth) were inversely associated with hyperactivity and total behavioural problems, and positively associated with the temperamental trait Effortful Control. Path analyses showed that Effortful Control mediated the effects of fetal growth on hyperactivity and total behavioural problems. Conclusions: Our results suggest that an adverse fetal environment is associated with behavioural problems in childhood, in particular in those children that show a low capacity for attentional and behavioural regulation. An adverse fetal environment might induce vulnerability for behavioural problems, or it might induce changes in temperament and behavioural problems independently, representing a common cause. Pathways are likely to be based on long-lasting neurodevelopmental alterations due to prenatal adversity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01946.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633 [article] Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children [Texte imprimé et/ou numérique] / Wolff SCHLOTZ, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur . - 2008 . - p.1228-1236. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1228-1236 Mots-clés : Fetal-growth temperament effortful-control behavioural-problems hyperactivity birth-weight Index. décimale : PER Périodiques Résumé : Background: Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on behaviour later in life. However, no study so far has examined effects on temperament and potential developmental pathways. Temperamental traits may be particularly susceptible to neurodevelopmental alterations, and they are linked to behavioural problems. Therefore, we tested for associations of fetal growth with behavioural problems in children and tested if temperament mediated such effects. Methods: One hundred and thirty-nine mother–child pairs were recruited in early pregnancy. Weight, head circumference and gestational age were measured at birth, and the mother reported on their child's behavioural problems and temperament at age 7 to 9 years. Results: Birth weight and head circumference at birth adjusted for gestational age (i.e., fetal growth) were inversely associated with hyperactivity and total behavioural problems, and positively associated with the temperamental trait Effortful Control. Path analyses showed that Effortful Control mediated the effects of fetal growth on hyperactivity and total behavioural problems. Conclusions: Our results suggest that an adverse fetal environment is associated with behavioural problems in childhood, in particular in those children that show a low capacity for attentional and behavioural regulation. An adverse fetal environment might induce vulnerability for behavioural problems, or it might induce changes in temperament and behavioural problems independently, representing a common cause. Pathways are likely to be based on long-lasting neurodevelopmental alterations due to prenatal adversity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01946.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633

Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring / Wolff SCHLOTZ in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.594-602 Titre : Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring Type de document : Texte imprimé et/ou numérique Auteurs : Wolff SCHLOTZ, Auteur ; Sian M. ROBINSON, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur ; Catherine GALE, Auteur Année de publication : 2010 Article en page(s) : p.594-602 Langues : Anglais (eng) Mots-clés : Fetal-programming folate behavioural-difficulties fetal-brain-growth hyperactivity peer-problems Index. décimale : PER Périodiques Résumé : Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring. Methods: In a prospective cohort study, maternal red blood cell folate (RCF) was measured at 14 weeks of pregnancy and total folate intake (TFI) from food and supplements was assessed in early and late pregnancy. The offspring's head circumference and body weight were measured at birth and in infancy, and 100 mothers reported on children's behavioural difficulties at a mean age of 8.75 years using the Strengths and Difficulties Questionnaire. Results: Lower maternal RCF and TFI in early pregnancy were associated with higher childhood hyperactivity (RCF: beta = −.24; p = .013; TFI: beta = −.24; p = .022) and peer problems scores (RCF: beta = −.28; p = .004; TFI: beta = −.28; p = .009) in the offspring. Maternal gestational RCF was positively associated with head circumference at birth (adjusted for gestational age), and mediation analyses showed significant inverse indirect associations of RCF with hyperactivity/inattention and peer problems via fetal brain growth. Adjustment for mother's smoking and drinking alcohol during pregnancy did not change the results. Conclusions: Although the associations are small and residual confounding is possible, our data provide preliminary support for the hypothesis that lower folate status in early pregnancy might impair fetal brain development and affect hyperactivity/inattention and peer problems in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02182.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring [Texte imprimé et/ou numérique] / Wolff SCHLOTZ, Auteur ; Sian M. ROBINSON, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur ; Catherine GALE, Auteur . - 2010 . - p.594-602. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.594-602 Mots-clés : Fetal-programming folate behavioural-difficulties fetal-brain-growth hyperactivity peer-problems Index. décimale : PER Périodiques Résumé : Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring. Methods: In a prospective cohort study, maternal red blood cell folate (RCF) was measured at 14 weeks of pregnancy and total folate intake (TFI) from food and supplements was assessed in early and late pregnancy. The offspring's head circumference and body weight were measured at birth and in infancy, and 100 mothers reported on children's behavioural difficulties at a mean age of 8.75 years using the Strengths and Difficulties Questionnaire. Results: Lower maternal RCF and TFI in early pregnancy were associated with higher childhood hyperactivity (RCF: beta = −.24; p = .013; TFI: beta = −.24; p = .022) and peer problems scores (RCF: beta = −.28; p = .004; TFI: beta = −.28; p = .009) in the offspring. Maternal gestational RCF was positively associated with head circumference at birth (adjusted for gestational age), and mediation analyses showed significant inverse indirect associations of RCF with hyperactivity/inattention and peer problems via fetal brain growth. Adjustment for mother's smoking and drinking alcohol during pregnancy did not change the results. Conclusions: Although the associations are small and residual confounding is possible, our data provide preliminary support for the hypothesis that lower folate status in early pregnancy might impair fetal brain development and affect hyperactivity/inattention and peer problems in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02182.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

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