[article]
| Titre : |
The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Nurit YIRMIYA, Auteur ; Tony CHARMAN, Auteur |
| Année de publication : |
2010 |
| Article en page(s) : |
p.432-458 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism-spectrum-disorders early-markers genetics brain-development siblings perinatal-development diagnosis |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the 'core' disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and 'high risk' sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. While no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate early presentation and even 'prevent' emergence of the full syndrome. |
| En ligne : |
http://dx.doi.org/10.1111/j.1469-7610.2010.02214.x |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=989 |
in Journal of Child Psychology and Psychiatry > 51-4 (April 2010) . - p.432-458
[article] The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics [Texte imprimé et/ou numérique] / Nurit YIRMIYA, Auteur ; Tony CHARMAN, Auteur . - 2010 . - p.432-458. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 51-4 (April 2010) . - p.432-458
| Mots-clés : |
Autism-spectrum-disorders early-markers genetics brain-development siblings perinatal-development diagnosis |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the 'core' disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and 'high risk' sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. While no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate early presentation and even 'prevent' emergence of the full syndrome. |
| En ligne : |
http://dx.doi.org/10.1111/j.1469-7610.2010.02214.x |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=989 |
|
The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics in Journal of Child Psychology and Psychiatry, 51-4 (April 2010)
