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Auteur Showming KWOK |
Documents disponibles écrits par cet auteur (1)
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PI3K Signaling and miRNA Regulation in Autism Spectrum Disorders / Showming KWOK
Titre : PI3K Signaling and miRNA Regulation in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Showming KWOK, Auteur ; Nikolaos MELLIOS, Auteur ; Mriganka SUR, Auteur Année de publication : 2013 Importance : p.449-459 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Despite the heterogeneity of autism spectrum disorders (ASD), dysregulation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has emerged as one potentially common and unifying theme. Multiple genes linked to syndromic or non-syndromic forms of ASD appear to interplay with small non-coding RNAs to generate a complex and interconnected molecular network that, when perturbed, results in alterations in protein synthesis and aberrant synaptic plasticity. In this chapter we attempt to elucidate the interactions between ASD-related genes and PI3K/Akt/mTOR signaling, with particular mention of the contribution of microRNAs (miRNAs), a category of non-coding RNAs with increased relevance to brain disorders. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 PI3K Signaling and miRNA Regulation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Showming KWOK, Auteur ; Nikolaos MELLIOS, Auteur ; Mriganka SUR, Auteur . - 2013 . - p.449-459.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Despite the heterogeneity of autism spectrum disorders (ASD), dysregulation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has emerged as one potentially common and unifying theme. Multiple genes linked to syndromic or non-syndromic forms of ASD appear to interplay with small non-coding RNAs to generate a complex and interconnected molecular network that, when perturbed, results in alterations in protein synthesis and aberrant synaptic plasticity. In this chapter we attempt to elucidate the interactions between ASD-related genes and PI3K/Akt/mTOR signaling, with particular mention of the contribution of microRNAs (miRNAs), a category of non-coding RNAs with increased relevance to brain disorders. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
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