3 recherche sur le mot-clé 'Drosophila'

The gut-microbiota-brain axis in autism: what Drosophila models can offer? / Safa SALIM in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : The gut-microbiota-brain axis in autism: what Drosophila models can offer? Type de document : texte imprimé Auteurs : Safa SALIM, Auteur ; Ayesha BANU, Auteur ; Amira ALWA, Auteur ; Swetha B.M. GOWDA, Auteur ; Farhan MOHAMMAD, Auteur Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder  Autistic Disorder  Brain  Drosophila  Gastrointestinal Microbiome  Humans  Autism spectrum disorders  Gastrointestinal issues  Gut-microbiome-brain axis Index. décimale : PER Périodiques Résumé : The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD. En ligne : https://dx.doi.org/10.1186/s11689-021-09378-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] The gut-microbiota-brain axis in autism: what Drosophila models can offer? [texte imprimé] / Safa SALIM, Auteur ; Ayesha BANU, Auteur ; Amira ALWA, Auteur ; Swetha B.M. GOWDA, Auteur ; Farhan MOHAMMAD, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Animals  Autism Spectrum Disorder  Autistic Disorder  Brain  Drosophila  Gastrointestinal Microbiome  Humans  Autism spectrum disorders  Gastrointestinal issues  Gut-microbiome-brain axis Index. décimale : PER Périodiques Résumé : The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD. En ligne : https://dx.doi.org/10.1186/s11689-021-09378-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

From wings to whiskers to stem cells: why every model matters in fragile X syndrome research / Soraya O. SANDOVAL in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : From wings to whiskers to stem cells: why every model matters in fragile X syndrome research Type de document : texte imprimé Auteurs : Soraya O. SANDOVAL, Auteur ; Natasha M. MÉNDEZ-ALBELO, Auteur ; Zhiyan XU, Auteur ; Xinyu ZHAO, Auteur Langues : Anglais (eng) Mots-clés : Animals  Humans  Disease Models, Animal  Fragile X Mental Retardation Protein/genetics  Fragile X Syndrome/genetics/physiopathology  Pluripotent Stem Cells  Drosophila  Fmr1  Fmrp  Fragile X syndrome  Human  Mouse  Neuron  Organoid  Stem cells  iPSCs Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is caused by epigenetic silencing of the X-linked fragile X messenger ribonucleoprotein 1 (FMR1) gene located on chromosome Xq27.3, which leads to the loss of its protein product, fragile X messenger ribonucleoprotein (FMRP). It is the most prevalent inherited form of intellectual disability and the highest single genetic cause of autism. Since the discovery of the genetic basis of FXS, extensive studies using animal models and human pluripotent stem cells have unveiled the functions of FMRP and mechanisms underlying FXS. However, clinical trials have not yielded successful treatment. Here we review what we have learned from commonly used models for FXS, potential limitations of these models, and recommendations for future steps. En ligne : https://dx.doi.org/10.1186/s11689-024-09545-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] From wings to whiskers to stem cells: why every model matters in fragile X syndrome research [texte imprimé] / Soraya O. SANDOVAL, Auteur ; Natasha M. MÉNDEZ-ALBELO, Auteur ; Zhiyan XU, Auteur ; Xinyu ZHAO, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Animals  Humans  Disease Models, Animal  Fragile X Mental Retardation Protein/genetics  Fragile X Syndrome/genetics/physiopathology  Pluripotent Stem Cells  Drosophila  Fmr1  Fmrp  Fragile X syndrome  Human  Mouse  Neuron  Organoid  Stem cells  iPSCs Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is caused by epigenetic silencing of the X-linked fragile X messenger ribonucleoprotein 1 (FMR1) gene located on chromosome Xq27.3, which leads to the loss of its protein product, fragile X messenger ribonucleoprotein (FMRP). It is the most prevalent inherited form of intellectual disability and the highest single genetic cause of autism. Since the discovery of the genetic basis of FXS, extensive studies using animal models and human pluripotent stem cells have unveiled the functions of FMRP and mechanisms underlying FXS. However, clinical trials have not yielded successful treatment. Here we review what we have learned from commonly used models for FXS, potential limitations of these models, and recommendations for future steps. En ligne : https://dx.doi.org/10.1186/s11689-024-09545-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Selecting the Right Species: Practical Information on Organism Models / Catherine BARTOLI

Public ISBD in Organism models of autism spectrum disorders / Pierre L. ROUBERTOUX Titre : Selecting the Right Species: Practical Information on Organism Models Type de document : texte imprimé Auteurs : Catherine BARTOLI, Auteur ; Arnaud BLANCHARD, Auteur ; Christine BUSKE, Auteur ; Gwenaelle COLLOD-BÉROUD, Auteur ; Laurent FASANO, Auteur ; Christophe SCAJOLA, Auteur ; Pierre L. ROUBERTOUX, Auteur Année de publication : 2015 Importance : p.67-97 Langues : Anglais (eng) Mots-clés : Yeast  Caenorhabditis elegans  Drosophila  Zebra fish  Dog  Nonhuman primates Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=265 in Organism models of autism spectrum disorders / Pierre L. ROUBERTOUX Selecting the Right Species: Practical Information on Organism Models [texte imprimé] / Catherine BARTOLI, Auteur ; Arnaud BLANCHARD, Auteur ; Christine BUSKE, Auteur ; Gwenaelle COLLOD-BÉROUD, Auteur ; Laurent FASANO, Auteur ; Christophe SCAJOLA, Auteur ; Pierre L. ROUBERTOUX, Auteur . - 2015 . - p.67-97. Langues : Anglais (eng) Mots-clés : Yeast  Caenorhabditis elegans  Drosophila  Zebra fish  Dog  Nonhuman primates Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=265

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