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in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : Mouse Behavior and Models for Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Laura RICCERI, Auteur ; Caterina MICHETTI, Auteur ; Maria Luisa SCATTONI, Auteur Année de publication : 2016 Importance : p.269-293 Langues : Anglais (eng) Mots-clés : Mouse behavior Mouse models Mutants Olfactory tests Repetitive behaviors Social approach Social communication Social interaction Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorders (ASDs) are behaviorally defined disorders including attenuated or abnormal social interaction and communication, as well as aberrant repetitive behavior, with symptoms emerging early in childhood. Although the cause of autism has not been discovered, several data strongly support the role of genetic factors in its etiology. For this reason, preclinical research has focused on transgenic and knockout mice bearing mutations in genes identified in autistic children, with the aim of understanding the role of those genes in autism etiology, discovering the biological mechanisms underlying behavioral alterations observed and evaluating potential treatments. In past years, a number of behavioral phenotyping assays for rodent models of autism and related disorders have been developed. In the first part of our review, we describe these behavioral paradigms currently used in ASD rodent models; the second part is an overview of valid and robust animal models of ASD. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00017-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Mouse Behavior and Models for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Laura RICCERI, Auteur ; Caterina MICHETTI, Auteur ; Maria Luisa SCATTONI, Auteur . - 2016 . - p.269-293.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Mouse behavior Mouse models Mutants Olfactory tests Repetitive behaviors Social approach Social communication Social interaction Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorders (ASDs) are behaviorally defined disorders including attenuated or abnormal social interaction and communication, as well as aberrant repetitive behavior, with symptoms emerging early in childhood. Although the cause of autism has not been discovered, several data strongly support the role of genetic factors in its etiology. For this reason, preclinical research has focused on transgenic and knockout mice bearing mutations in genes identified in autistic children, with the aim of understanding the role of those genes in autism etiology, discovering the biological mechanisms underlying behavioral alterations observed and evaluating potential treatments. In past years, a number of behavioral phenotyping assays for rodent models of autism and related disorders have been developed. In the first part of our review, we describe these behavioral paradigms currently used in ASD rodent models; the second part is an overview of valid and robust animal models of ASD. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00017-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
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