Allostatic processes in the family / Rena L. REPETTI in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.921-938 Titre : Allostatic processes in the family Type de document : Texte imprimé et/ou numérique Auteurs : Rena L. REPETTI, Auteur ; Theodore F. ROBLES, Auteur ; Bridget REYNOLDS, Auteur Année de publication : 2011 Article en page(s) : p.921-938 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The concepts of allostatic load and allostatic processes can help psychologists understand how health trajectories are influenced by stressful childhood experiences in the family. This paper describes psychological pathways and two key allostatic mediators, the hypothalamic–pituitary–adrenal axis and the immune system, through which stressful early rearing conditions may influence adult mental and physical health. The action of meshed gears is introduced as a metaphor to illustrate how responses occurring within a brief time frame, for example, immediate reactions to stressors, can influence developmental and health processes unfolding over much longer spans of time. We identify early-developing psychological and biological response patterns that could link chronic stressors in childhood to later health outcomes. Some of these “precursor outcomes” (e.g., heightened vigilance and preparedness for threats; enhanced inflammatory and humoral responses to infectious microorganisms) appear to be aimed at protection from immediate dangers; they may reflect “adaptive trade-offs” that balance short-term survival advantages under harsh rearing conditions against disadvantages manifested later in development. Our analysis also suggests mechanisms that underlie resilience in risky family environments. En ligne : http://dx.doi.org/10.1017/S095457941100040X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Allostatic processes in the family [Texte imprimé et/ou numérique] / Rena L. REPETTI, Auteur ; Theodore F. ROBLES, Auteur ; Bridget REYNOLDS, Auteur . - 2011 . - p.921-938. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.921-938 Index. décimale : PER Périodiques Résumé : The concepts of allostatic load and allostatic processes can help psychologists understand how health trajectories are influenced by stressful childhood experiences in the family. This paper describes psychological pathways and two key allostatic mediators, the hypothalamic–pituitary–adrenal axis and the immune system, through which stressful early rearing conditions may influence adult mental and physical health. The action of meshed gears is introduced as a metaphor to illustrate how responses occurring within a brief time frame, for example, immediate reactions to stressors, can influence developmental and health processes unfolding over much longer spans of time. We identify early-developing psychological and biological response patterns that could link chronic stressors in childhood to later health outcomes. Some of these “precursor outcomes” (e.g., heightened vigilance and preparedness for threats; enhanced inflammatory and humoral responses to infectious microorganisms) appear to be aimed at protection from immediate dangers; they may reflect “adaptive trade-offs” that balance short-term survival advantages under harsh rearing conditions against disadvantages manifested later in development. Our analysis also suggests mechanisms that underlie resilience in risky family environments. En ligne : http://dx.doi.org/10.1017/S095457941100040X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Annual Research Review: Social relationships and the immune system during development / Theodore F. ROBLES in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.539-559 Titre : Annual Research Review: Social relationships and the immune system during development Type de document : Texte imprimé et/ou numérique Auteurs : Theodore F. ROBLES, Auteur Article en page(s) : p.539-559 Langues : Anglais (eng) Mots-clés : Social factors  biology  family functioning  parent-child relationships  peer relationships Index. décimale : PER Périodiques Résumé : A child's social relationships serve critical functions during development. The interface between a child's social world and their immune system, particularly innate immunity, which helped children survive in the face of infections, nutritional scarcity, and violence throughout human history, is the focus of this Annual Research Review. This article reviews the state of research on social relationships and innate immune inflammation during childhood. Warmth and rejection in childhood social relationships, as well as physical trauma and unpredictable social environments, were not consistently related to circulating inflammatory markers such as interleukin-6 and C-reactive protein during childhood. Instead, links between social environments and inflammation were observed in studies that focus on children with greater background risk factors, such as low family socioeconomic status, family history of mood disorders, or presence of chronic interpersonal stressors combined with acute episodic stressors. In addition, studies on worse childhood social environments and greater inflammation in adulthood were more consistent. Warmth and rejection in the social environment may be related to sensitivity of immune cells to the anti-inflammatory actions of glucocorticoids, though this is primarily observed in adolescent women at risk for depression. Additional mechanistic evidence suggests that greater warmth and less rejection are related to processes that regulate inflammation, including greater expression of the glucocorticoid receptor gene and lower expression of genes that are responsive to the pro-inflammatory transcription factor NF-kappa B. The article concludes by discussing implications of the interface between a child's social relationships and inflammation for mental health and other recent (on evolutionary timescales) health threats, as well as recommendations for future research, and recommendations for researchers interested in integrating inflammatory measures in developmental research. En ligne : http://dx.doi.org/10.1111/jcpp.13350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Annual Research Review: Social relationships and the immune system during development [Texte imprimé et/ou numérique] / Theodore F. ROBLES, Auteur . - p.539-559. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.539-559 Mots-clés : Social factors  biology  family functioning  parent-child relationships  peer relationships Index. décimale : PER Périodiques Résumé : A child's social relationships serve critical functions during development. The interface between a child's social world and their immune system, particularly innate immunity, which helped children survive in the face of infections, nutritional scarcity, and violence throughout human history, is the focus of this Annual Research Review. This article reviews the state of research on social relationships and innate immune inflammation during childhood. Warmth and rejection in childhood social relationships, as well as physical trauma and unpredictable social environments, were not consistently related to circulating inflammatory markers such as interleukin-6 and C-reactive protein during childhood. Instead, links between social environments and inflammation were observed in studies that focus on children with greater background risk factors, such as low family socioeconomic status, family history of mood disorders, or presence of chronic interpersonal stressors combined with acute episodic stressors. In addition, studies on worse childhood social environments and greater inflammation in adulthood were more consistent. Warmth and rejection in the social environment may be related to sensitivity of immune cells to the anti-inflammatory actions of glucocorticoids, though this is primarily observed in adolescent women at risk for depression. Additional mechanistic evidence suggests that greater warmth and less rejection are related to processes that regulate inflammation, including greater expression of the glucocorticoid receptor gene and lower expression of genes that are responsive to the pro-inflammatory transcription factor NF-kappa B. The article concludes by discussing implications of the interface between a child's social relationships and inflammation for mental health and other recent (on evolutionary timescales) health threats, as well as recommendations for future research, and recommendations for researchers interested in integrating inflammatory measures in developmental research. En ligne : http://dx.doi.org/10.1111/jcpp.13350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Family environments and leukocyte transcriptome indicators of a proinflammatory phenotype in children and parents / Theodore F. ROBLES in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.235-253 Titre : Family environments and leukocyte transcriptome indicators of a proinflammatory phenotype in children and parents Type de document : Texte imprimé et/ou numérique Auteurs : Theodore F. ROBLES, Auteur ; Rena L. REPETTI, Auteur ; Bridget M. REYNOLDS, Auteur ; Paul J. CHUNG, Auteur ; Jesusa M. G. AREVALO, Auteur ; Steven W. COLE, Auteur Article en page(s) : p.235-253 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : High conflict and low warmth in families may contribute to immune cells developing a tendency to respond to threats with exaggerated inflammation that is insensitive to inhibitory signaling. We tested associations between family environments and expression of genes bearing response elements for transcription factors that regulate inflammation: nuclear factor kappa B (NF-?B) and glucocorticoid receptor. The overall sample (47 families) completed interviews, questionnaires, and 8-week daily diary assessments of conflict and warmth, which were used to create composite family conflict and warmth scores. The diaries assessed upper respiratory infection (URI) symptoms, and URI episodes were clinically verified. Leukocyte RNA was extracted from whole blood samples provided by a subsample of 42 children (8–13 years of age) and 73 parents. In children, higher conflict and lower warmth were related to greater expression of genes bearing response elements for the proinflammatory transcription factor NF-?B, and more severe URI symptoms. In parents, higher conflict and lower warmth were also related to greater NF-?B–associated gene expression. Monocytes and dendritic cells were implicated as primary cellular sources of differential gene expression in the sample. Consistent with existing conceptual frameworks, stressful family environments were related to a proinflammatory phenotype at the level of the circulating leukocyte transcriptome. En ligne : https://doi.org/10.1017/S0954579417000591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Family environments and leukocyte transcriptome indicators of a proinflammatory phenotype in children and parents [Texte imprimé et/ou numérique] / Theodore F. ROBLES, Auteur ; Rena L. REPETTI, Auteur ; Bridget M. REYNOLDS, Auteur ; Paul J. CHUNG, Auteur ; Jesusa M. G. AREVALO, Auteur ; Steven W. COLE, Auteur . - p.235-253. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.235-253 Index. décimale : PER Périodiques Résumé : High conflict and low warmth in families may contribute to immune cells developing a tendency to respond to threats with exaggerated inflammation that is insensitive to inhibitory signaling. We tested associations between family environments and expression of genes bearing response elements for transcription factors that regulate inflammation: nuclear factor kappa B (NF-?B) and glucocorticoid receptor. The overall sample (47 families) completed interviews, questionnaires, and 8-week daily diary assessments of conflict and warmth, which were used to create composite family conflict and warmth scores. The diaries assessed upper respiratory infection (URI) symptoms, and URI episodes were clinically verified. Leukocyte RNA was extracted from whole blood samples provided by a subsample of 42 children (8–13 years of age) and 73 parents. In children, higher conflict and lower warmth were related to greater expression of genes bearing response elements for the proinflammatory transcription factor NF-?B, and more severe URI symptoms. In parents, higher conflict and lower warmth were also related to greater NF-?B–associated gene expression. Monocytes and dendritic cells were implicated as primary cellular sources of differential gene expression in the sample. Consistent with existing conceptual frameworks, stressful family environments were related to a proinflammatory phenotype at the level of the circulating leukocyte transcriptome. En ligne : https://doi.org/10.1017/S0954579417000591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

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