Abnormal lateralization of functional connectivity between language and default mode regions in autism / Jared A. NIELSEN in Molecular Autism, (February 2014)  

Public ISBD [article]  inMolecular Autism > (February 2014) Titre : Abnormal lateralization of functional connectivity between language and default mode regions in autism Type de document : texte imprimé Auteurs : Jared A. NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Abnormal lateralization of functional connectivity between language and default mode regions in autism [texte imprimé] / Jared A. NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation / Brittany G. TRAVERS in Molecular Autism, (March 2015)  

Public ISBD [article]  inMolecular Autism > (March 2015) . - p.1-15 Titre : Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation Type de document : texte imprimé Auteurs : Brittany G. TRAVERS, Auteur ; Do P.M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly D.B. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur Article en page(s) : p.1-15 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation [texte imprimé] / Brittany G. TRAVERS, Auteur ; Do P.M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly D.B. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur . - p.1-15. Langues : Anglais (eng) in Molecular Autism > (March 2015) . - p.1-15 Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Corpus callosum area in children and adults with autism / Molly D.B. PRIGGE in Research in Autism Spectrum Disorders, 7-2 (February 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Titre : Corpus callosum area in children and adults with autism Type de document : texte imprimé Auteurs : Molly D.B. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2013 Article en page(s) : p.221-234 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Corpus callosum area in children and adults with autism [texte imprimé] / Molly D.B. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2013 . - p.221-234. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Functional MRI in Autism / Jeffrey S. ANDERSON

Public ISBD in Imaging the Brain in Autism / Manuel F. CASANOVA Titre : Functional MRI in Autism Type de document : texte imprimé Auteurs : Jeffrey S. ANDERSON, Auteur ; Michael A. FERGUSON, Auteur ; Jared A. NIELSEN, Auteur Année de publication : 2013 Importance : p.289-323 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 in Imaging the Brain in Autism / Manuel F. CASANOVA Functional MRI in Autism [texte imprimé] / Jeffrey S. ANDERSON, Auteur ; Michael A. FERGUSON, Auteur ; Jared A. NIELSEN, Auteur . - 2013 . - p.289-323. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

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Intact prototype formation but impaired generalization in autism / A.H. FROEHLICH in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.921-930 Titre : Intact prototype formation but impaired generalization in autism Type de document : texte imprimé Auteurs : A.H. FROEHLICH, Auteur ; Jeffrey S. ANDERSON, Auteur ; Erin D. BIGLER, Auteur ; Judith S. MILLER, Auteur ; Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Jared A. NIELSEN, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2012 Article en page(s) : p.921-930 Langues : Anglais (eng) Mots-clés : Prototype  Autism  Categorization  Recognition  Generalization  fMRI Index. décimale : PER Périodiques Résumé : Cognitive processing in autism has been characterized by a difficulty with the abstraction of information across multiple stimuli or situations and subsequent generalization to new stimuli or situations. This apparent difficulty leads to the suggestion that prototype formation, a process of creating a mental summary representation of multiple experienced stimuli that go together in a category, may be impaired in autism. Adults with high functioning autism and a typically developing comparison group matched on age and IQ completed a random dot pattern categorization task. Participants with autism demonstrated intact prototype formation in all four ways it was operationally defined, and this performance was not significantly different from that of control participants. However, participants with autism categorized dot patterns that were more highly distorted from the category prototypes less accurately than did control participants. These findings suggest, at least within the constraints of the random dot pattern task, that although prototype formation may not be impaired in autism, difficulties may exist with the generalization of what has been learned about a category to novel stimuli, particularly as they become less similar to the category's prototype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] Intact prototype formation but impaired generalization in autism [texte imprimé] / A.H. FROEHLICH, Auteur ; Jeffrey S. ANDERSON, Auteur ; Erin D. BIGLER, Auteur ; Judith S. MILLER, Auteur ; Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Jared A. NIELSEN, Auteur ; Janet E. LAINHART, Auteur . - 2012 . - p.921-930. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.921-930 Mots-clés : Prototype  Autism  Categorization  Recognition  Generalization  fMRI Index. décimale : PER Périodiques Résumé : Cognitive processing in autism has been characterized by a difficulty with the abstraction of information across multiple stimuli or situations and subsequent generalization to new stimuli or situations. This apparent difficulty leads to the suggestion that prototype formation, a process of creating a mental summary representation of multiple experienced stimuli that go together in a category, may be impaired in autism. Adults with high functioning autism and a typically developing comparison group matched on age and IQ completed a random dot pattern categorization task. Participants with autism demonstrated intact prototype formation in all four ways it was operationally defined, and this performance was not significantly different from that of control participants. However, participants with autism categorized dot patterns that were more highly distorted from the category prototypes less accurately than did control participants. These findings suggest, at least within the constraints of the random dot pattern task, that although prototype formation may not be impaired in autism, difficulties may exist with the generalization of what has been learned about a category to novel stimuli, particularly as they become less similar to the category's prototype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Longitudinal Heschl's Gyrus Growth During Childhood and Adolescence in Typical Development and Autism / Molly D.B. PRIGGE in Autism Research, 6-2 (April 2013)  

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Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years / Nicholas LANGE in Autism Research, 8-1 (February 2015)  

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Structural Imaging in Autism / Brandon A. ZIELINSKI

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Violence: heightened brain attentional network response is selectively muted in Down syndrome / Jeffrey S. ANDERSON in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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