Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Molly B. DUBRAY |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Atypical diffusion tensor hemispheric asymmetry in autism / Nicholas LANGE in Autism Research, 3-6 (December 2010)
[article]
Titre : Atypical diffusion tensor hemispheric asymmetry in autism Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2010 Article en page(s) : p.350-358 Langues : Anglais (eng) Mots-clés : adaptive functioning classification diffusion tensor imaging hemispheric asymmetry language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-6 (December 2010) . - p.350-358[article] Atypical diffusion tensor hemispheric asymmetry in autism [Texte imprimé et/ou numérique] / Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2010 . - p.350-358.
Langues : Anglais (eng)
in Autism Research > 3-6 (December 2010) . - p.350-358
Mots-clés : adaptive functioning classification diffusion tensor imaging hemispheric asymmetry language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Intact prototype formation but impaired generalization in autism / A.H. FROEHLICH in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)
[article]
Titre : Intact prototype formation but impaired generalization in autism Type de document : Texte imprimé et/ou numérique Auteurs : A.H. FROEHLICH, Auteur ; Jeffrey S. ANDERSON, Auteur ; Erin D. BIGLER, Auteur ; J. S. MILLER, Auteur ; N. T. LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; J. A. NIELSEN, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2012 Article en page(s) : p.921-930 Langues : Anglais (eng) Mots-clés : Prototype Autism Categorization Recognition Generalization fMRI Index. décimale : PER Périodiques Résumé : Cognitive processing in autism has been characterized by a difficulty with the abstraction of information across multiple stimuli or situations and subsequent generalization to new stimuli or situations. This apparent difficulty leads to the suggestion that prototype formation, a process of creating a mental summary representation of multiple experienced stimuli that go together in a category, may be impaired in autism. Adults with high functioning autism and a typically developing comparison group matched on age and IQ completed a random dot pattern categorization task. Participants with autism demonstrated intact prototype formation in all four ways it was operationally defined, and this performance was not significantly different from that of control participants. However, participants with autism categorized dot patterns that were more highly distorted from the category prototypes less accurately than did control participants. These findings suggest, at least within the constraints of the random dot pattern task, that although prototype formation may not be impaired in autism, difficulties may exist with the generalization of what has been learned about a category to novel stimuli, particularly as they become less similar to the category's prototype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150
in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.921-930[article] Intact prototype formation but impaired generalization in autism [Texte imprimé et/ou numérique] / A.H. FROEHLICH, Auteur ; Jeffrey S. ANDERSON, Auteur ; Erin D. BIGLER, Auteur ; J. S. MILLER, Auteur ; N. T. LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; J. A. NIELSEN, Auteur ; Janet E. LAINHART, Auteur . - 2012 . - p.921-930.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.921-930
Mots-clés : Prototype Autism Categorization Recognition Generalization fMRI Index. décimale : PER Périodiques Résumé : Cognitive processing in autism has been characterized by a difficulty with the abstraction of information across multiple stimuli or situations and subsequent generalization to new stimuli or situations. This apparent difficulty leads to the suggestion that prototype formation, a process of creating a mental summary representation of multiple experienced stimuli that go together in a category, may be impaired in autism. Adults with high functioning autism and a typically developing comparison group matched on age and IQ completed a random dot pattern categorization task. Participants with autism demonstrated intact prototype formation in all four ways it was operationally defined, and this performance was not significantly different from that of control participants. However, participants with autism categorized dot patterns that were more highly distorted from the category prototypes less accurately than did control participants. These findings suggest, at least within the constraints of the random dot pattern task, that although prototype formation may not be impaired in autism, difficulties may exist with the generalization of what has been learned about a category to novel stimuli, particularly as they become less similar to the category's prototype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150