An Abnormal Cerebellar Network in Children with Autistic Spectrum Disorder: A Morphometric Study / Alessandro GRECUCCI in Autism - Open Access, 6-3 ([01/05/2016])  

Public ISBD [article]  inAutism - Open Access > 6-3 [01/05/2016] . - 6 p. Titre : An Abnormal Cerebellar Network in Children with Autistic Spectrum Disorder: A Morphometric Study Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro GRECUCCI, Auteur ; Edoardo PAPPAIANNI, Auteur ; Roma SIUGZDAITE, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism  Structural differences  Source based morphometry  Biological markers Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder characterized by poor social abilities, communication deficiency and restricted behavioural patterns. Recently, scholars started to consider the possibility of detecting biological markers for better and faster diagnosing autism. This problem has been approached from different perspectives considering biochemical, neurophysiological, and neuroanatomical markers. Following this perspective, our intent was to investigate whether a structural brain signature of autism can be detected in children by using a whole brain morphological analysis. To this aim, we selected 43 male children with autistic spectrum disorder and 46 male controls, matched for age. Structural brain images (T1 image), intelligence scores (Full IQ, Verbal IQ, Performance IQ), and Autism Diagnostic Observation Schedule (ADOS) scores were considered for analyses. Source-Based Morphometry, a multivariate method based on Independent Component Analysis to detect maximally independent cortical networks of gray matter differences was applied to autistic and control brains. Results showed a statistically different network between ASD children and controls, including several cerebellar regions (Inferior Semi-lunarlobule, Tuble, Uvula, Pyramis, Declive, Cerebellar Tonsil) and the Fusiform Gyrus, confirming, but, also expanding previous results. In addition, separate temporal, frontal, and parietal networks were found to be significantly correlated with the Stereotyped Behaviour ADOS scores. These morphologic differences may be particularly useful in paving the way for future objective methods to diagnose autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] An Abnormal Cerebellar Network in Children with Autistic Spectrum Disorder: A Morphometric Study [Texte imprimé et/ou numérique] / Alessandro GRECUCCI, Auteur ; Edoardo PAPPAIANNI, Auteur ; Roma SIUGZDAITE, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 6-3 [01/05/2016] . - 6 p. Mots-clés : Autism  Structural differences  Source based morphometry  Biological markers Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder characterized by poor social abilities, communication deficiency and restricted behavioural patterns. Recently, scholars started to consider the possibility of detecting biological markers for better and faster diagnosing autism. This problem has been approached from different perspectives considering biochemical, neurophysiological, and neuroanatomical markers. Following this perspective, our intent was to investigate whether a structural brain signature of autism can be detected in children by using a whole brain morphological analysis. To this aim, we selected 43 male children with autistic spectrum disorder and 46 male controls, matched for age. Structural brain images (T1 image), intelligence scores (Full IQ, Verbal IQ, Performance IQ), and Autism Diagnostic Observation Schedule (ADOS) scores were considered for analyses. Source-Based Morphometry, a multivariate method based on Independent Component Analysis to detect maximally independent cortical networks of gray matter differences was applied to autistic and control brains. Results showed a statistically different network between ASD children and controls, including several cerebellar regions (Inferior Semi-lunarlobule, Tuble, Uvula, Pyramis, Declive, Cerebellar Tonsil) and the Fusiform Gyrus, confirming, but, also expanding previous results. In addition, separate temporal, frontal, and parietal networks were found to be significantly correlated with the Stereotyped Behaviour ADOS scores. These morphologic differences may be particularly useful in paving the way for future objective methods to diagnose autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Emotional Resonance Deficits in Autistic Children / Alessandro GRECUCCI in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.616-628 Titre : Emotional Resonance Deficits in Autistic Children Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro GRECUCCI, Auteur ; Paolo BRAMBILLA, Auteur ; Roma SIUGZDAITE, Auteur ; Danielle LONDERO, Auteur ; Franco FABBRO, Auteur ; Raffaella Ida RUMIATI, Auteur Article en page(s) : p.616-628 Langues : Anglais (eng) Mots-clés : Imitation  Action resonance  Empathy  Emotions  Mirror neurons Index. décimale : PER Périodiques Résumé : According to some theories imitation, defined as an action resonance mechanism, is deficient in autism. In contrast, other theories (e.g., the “top down control of imitation” hypothesis) state that the problem is not in imitation per se but in the way social cues modulate imitative responses. In this study, 15 high-functioning children with autism and 15 matched controls were tested for their ability to imitate finger movements preceded by neutral and emotional facial expressions (primes) in a stimulus–response compatibility task. Hand movements performed after neutral expressions did not differ between the two groups (i.e., they both showed a normal imitative tendency). However, hand movements performed after emotional expressions significantly differed between the two populations, with controls, but not autistic spectrum disorder (ASD), showing enhanced imitation in the emotional condition. This study supports the view that, in ASD, imitation abilities are spared but they are not modulated according to the emotional and social context. En ligne : http://dx.doi.org/10.1007/s10803-012-1603-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Emotional Resonance Deficits in Autistic Children [Texte imprimé et/ou numérique] / Alessandro GRECUCCI, Auteur ; Paolo BRAMBILLA, Auteur ; Roma SIUGZDAITE, Auteur ; Danielle LONDERO, Auteur ; Franco FABBRO, Auteur ; Raffaella Ida RUMIATI, Auteur . - p.616-628. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.616-628 Mots-clés : Imitation  Action resonance  Empathy  Emotions  Mirror neurons Index. décimale : PER Périodiques Résumé : According to some theories imitation, defined as an action resonance mechanism, is deficient in autism. In contrast, other theories (e.g., the “top down control of imitation” hypothesis) state that the problem is not in imitation per se but in the way social cues modulate imitative responses. In this study, 15 high-functioning children with autism and 15 matched controls were tested for their ability to imitate finger movements preceded by neutral and emotional facial expressions (primes) in a stimulus–response compatibility task. Hand movements performed after neutral expressions did not differ between the two groups (i.e., they both showed a normal imitative tendency). However, hand movements performed after emotional expressions significantly differed between the two populations, with controls, but not autistic spectrum disorder (ASD), showing enhanced imitation in the emotional condition. This study supports the view that, in ASD, imitation abilities are spared but they are not modulated according to the emotional and social context. En ligne : http://dx.doi.org/10.1007/s10803-012-1603-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

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