Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Hannah HAYWARD |
Documents disponibles écrits par cet auteur (5)
Faire une suggestion Affiner la recherche
Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? / C. Ellie WILSON in Autism, 20-7 (October 2016)
[article]
Titre : Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Type de document : Texte imprimé et/ou numérique Auteurs : C. Ellie WILSON, Auteur ; Clodagh M. MURPHY, Auteur ; Grainne MCALONAN, Auteur ; Dene M ROBERTSON, Auteur ; Debbie SPAIN, Auteur ; Hannah HAYWARD, Auteur ; Emma WOODHOUSE, Auteur ; Quinton DEELEY, Auteur ; Nicola GILLAN, Auteur ; J Chris OHLSEN, Auteur ; Janneke ZINKSTOK, Auteur ; Vladimira STOENCHEVA, Auteur ; Jessica FAULKNER, Auteur ; Hatice YILDIRAN, Auteur ; Vaughan BELL, Auteur ; Neil HAMMOND, Auteur ; Michael C. CRAIG, Auteur ; Declan GM MURPHY, Auteur Article en page(s) : p.808-819 Langues : Anglais (eng) Mots-clés : autism spectrum disorder diagnosis females males sex differences Index. décimale : PER Périodiques Résumé : It is unknown whether sex influences the diagnostic evaluation of autism spectrum disorder, or whether male and female adults within the spectrum have different symptom profiles. This study reports sex differences in clinical outcomes for 1244 adults (935 males and 309 females) referred for autism spectrum disorder assessment. Significantly, more males (72%) than females (66%) were diagnosed with an autism spectrum disorder of any subtype (x2?=?4.09; p?=?0.04). In high-functioning autism spectrum disorder adults (IQ?>?70; N?=?827), there were no significant sex differences in severity of socio-communicative domain symptoms. Males had significantly more repetitive behaviours/restricted interests than females (p?=?0.001, d?=?0.3). A multivariate analysis of variance indicated a significant interaction between autism spectrum disorder subtype (full-autism spectrum disorder/partial-autism spectrum disorder) and sex: in full-autism spectrum disorder, males had more severe socio-communicative symptoms than females; for partial-autism spectrum disorder, the reverse was true. There were no sex differences in prevalence of co-morbid psychopathologies. Sex influenced diagnostic evaluation in a clinical sample of adults with suspected autism spectrum disorder. The sexes may present with different manifestations of the autism spectrum disorder phenotype and differences vary by diagnostic subtype. Understanding and awareness of adult female repetitive behaviours/restricted interests warrant attention and sex-specific diagnostic assessment tools may need to be considered. En ligne : http://dx.doi.org/10.1177/1362361315611381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293
in Autism > 20-7 (October 2016) . - p.808-819[article] Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? [Texte imprimé et/ou numérique] / C. Ellie WILSON, Auteur ; Clodagh M. MURPHY, Auteur ; Grainne MCALONAN, Auteur ; Dene M ROBERTSON, Auteur ; Debbie SPAIN, Auteur ; Hannah HAYWARD, Auteur ; Emma WOODHOUSE, Auteur ; Quinton DEELEY, Auteur ; Nicola GILLAN, Auteur ; J Chris OHLSEN, Auteur ; Janneke ZINKSTOK, Auteur ; Vladimira STOENCHEVA, Auteur ; Jessica FAULKNER, Auteur ; Hatice YILDIRAN, Auteur ; Vaughan BELL, Auteur ; Neil HAMMOND, Auteur ; Michael C. CRAIG, Auteur ; Declan GM MURPHY, Auteur . - p.808-819.
Langues : Anglais (eng)
in Autism > 20-7 (October 2016) . - p.808-819
Mots-clés : autism spectrum disorder diagnosis females males sex differences Index. décimale : PER Périodiques Résumé : It is unknown whether sex influences the diagnostic evaluation of autism spectrum disorder, or whether male and female adults within the spectrum have different symptom profiles. This study reports sex differences in clinical outcomes for 1244 adults (935 males and 309 females) referred for autism spectrum disorder assessment. Significantly, more males (72%) than females (66%) were diagnosed with an autism spectrum disorder of any subtype (x2?=?4.09; p?=?0.04). In high-functioning autism spectrum disorder adults (IQ?>?70; N?=?827), there were no significant sex differences in severity of socio-communicative domain symptoms. Males had significantly more repetitive behaviours/restricted interests than females (p?=?0.001, d?=?0.3). A multivariate analysis of variance indicated a significant interaction between autism spectrum disorder subtype (full-autism spectrum disorder/partial-autism spectrum disorder) and sex: in full-autism spectrum disorder, males had more severe socio-communicative symptoms than females; for partial-autism spectrum disorder, the reverse was true. There were no sex differences in prevalence of co-morbid psychopathologies. Sex influenced diagnostic evaluation in a clinical sample of adults with suspected autism spectrum disorder. The sexes may present with different manifestations of the autism spectrum disorder phenotype and differences vary by diagnostic subtype. Understanding and awareness of adult female repetitive behaviours/restricted interests warrant attention and sex-specific diagnostic assessment tools may need to be considered. En ligne : http://dx.doi.org/10.1177/1362361315611381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 Mapping the link between socio-economic factors, autistic traits and mental health across different settings / Teresa DEL BIANCO in Autism, 28-5 (May 2024)
[article]
Titre : Mapping the link between socio-economic factors, autistic traits and mental health across different settings Type de document : Texte imprimé et/ou numérique Auteurs : Teresa DEL BIANCO, Auteur ; Georgia LOCKWOOD ESTRIN, Auteur ; Julian TILLMANN, Auteur ; Bethany F. OAKLEY, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Hannah HAYWARD, Auteur ; Mandy POTTER, Auteur ; Wendy MACKAY, Auteur ; Petrusa SMIT, Auteur ; Carlie DU PLESSIS, Auteur ; Lucy BRINK, Auteur ; Priscilla SPRINGER, Auteur ; Hein ODENDAAL, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Mark JOHNSON, Auteur ; Declan MURPHY, Auteur ; Jan BUITELAAR, Auteur ; Eva LOTH, Auteur ; Emily JH JONES, Auteur Article en page(s) : p.1280-1296 Langues : Anglais (eng) Mots-clés : autism spectrum disorders environmental factors Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher rates of externalising and internalising symptoms that may vary with environmental factors. However, there is limited research on variation across settings that may highlight common factors with globally generalisable effects. Data were taken from two cohorts: a multinational European sample (n = 764; 453 autistic; 311 non-autistic; 6-30?years), and a South African sample (n = 100 non-autistic; 3-11?years). An exploratory factor analysis aggregated clinical (Verbal Comprehension and Perceptual Index), adaptive traits (Vineland Adaptive Behaviour Scale) and socio-economic variables (parental employment and education, home and family characteristics) in each cohort separately. With regression, we investigated the effect of these factors and autistic traits on internalising and externalising scores (measured with the Strengths and Difficulties Questionnaire). Cohorts showed similar four-factor structures (Person Characteristics, Family System, Parental and Material Resources). The 'Family System' factor captured family size and maternal factors and was associated with lower internalising and externalising symptoms in both cohorts. In the European cohort, high autistic traits reduced this effect; the opposite was found in the South Africa cohort. Our exploratory findings from two separate analyses represent consistent evidence that Family System is associated with internalising and externalising symptoms, with a context-specific impact in persons with high autism traits. Lay Abstract Autistic individuals are more likely than non-autistic individuals to experience a mental health condition in their lifetime, and this includes externalising and internalising symptoms. We know very little about how different environments and family conditions impact these symptoms for autistic individuals. Improving our understanding of these relationships is important so that we can identify individuals who may be in greater need of support. In this article, we seek to improve our understanding of how environmental and family conditions impact externalising and internalising symptoms in autistic and non-autistic people. To do this, we conducted analyses with two cohorts in very different settings - in Europe and South Africa - to ensure our findings are globally representative. We used advanced statistical methods to establish environmental and family conditions that were similar to each other, and which could be combined into specific 'factors'. We found that four similar 'factors' could be identified in the two cohorts. These were distinguished by personal characteristics and environmental conditions of individuals, and were named Person Characteristics, Family System, Parental and Material Resources. Interestingly, just 'Family System' was associated with internalising and externalising symptoms, and this was the same in both cohorts. We also found that having high traits of autism impacted this relationship between Family System and mental health conditions with opposite directions in the two settings. These results show that characteristics in the Family System are associated with internalising and externalising symptoms, and autistic persons are particularly impacted, reinforcing the notion that family stressors are important to consider when implementing policy and practice related to improving the mental health of autistic people. En ligne : https://dx.doi.org/10.1177/13623613231200297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=527
in Autism > 28-5 (May 2024) . - p.1280-1296[article] Mapping the link between socio-economic factors, autistic traits and mental health across different settings [Texte imprimé et/ou numérique] / Teresa DEL BIANCO, Auteur ; Georgia LOCKWOOD ESTRIN, Auteur ; Julian TILLMANN, Auteur ; Bethany F. OAKLEY, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Hannah HAYWARD, Auteur ; Mandy POTTER, Auteur ; Wendy MACKAY, Auteur ; Petrusa SMIT, Auteur ; Carlie DU PLESSIS, Auteur ; Lucy BRINK, Auteur ; Priscilla SPRINGER, Auteur ; Hein ODENDAAL, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Mark JOHNSON, Auteur ; Declan MURPHY, Auteur ; Jan BUITELAAR, Auteur ; Eva LOTH, Auteur ; Emily JH JONES, Auteur . - p.1280-1296.
Langues : Anglais (eng)
in Autism > 28-5 (May 2024) . - p.1280-1296
Mots-clés : autism spectrum disorders environmental factors Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher rates of externalising and internalising symptoms that may vary with environmental factors. However, there is limited research on variation across settings that may highlight common factors with globally generalisable effects. Data were taken from two cohorts: a multinational European sample (n = 764; 453 autistic; 311 non-autistic; 6-30?years), and a South African sample (n = 100 non-autistic; 3-11?years). An exploratory factor analysis aggregated clinical (Verbal Comprehension and Perceptual Index), adaptive traits (Vineland Adaptive Behaviour Scale) and socio-economic variables (parental employment and education, home and family characteristics) in each cohort separately. With regression, we investigated the effect of these factors and autistic traits on internalising and externalising scores (measured with the Strengths and Difficulties Questionnaire). Cohorts showed similar four-factor structures (Person Characteristics, Family System, Parental and Material Resources). The 'Family System' factor captured family size and maternal factors and was associated with lower internalising and externalising symptoms in both cohorts. In the European cohort, high autistic traits reduced this effect; the opposite was found in the South Africa cohort. Our exploratory findings from two separate analyses represent consistent evidence that Family System is associated with internalising and externalising symptoms, with a context-specific impact in persons with high autism traits. Lay Abstract Autistic individuals are more likely than non-autistic individuals to experience a mental health condition in their lifetime, and this includes externalising and internalising symptoms. We know very little about how different environments and family conditions impact these symptoms for autistic individuals. Improving our understanding of these relationships is important so that we can identify individuals who may be in greater need of support. In this article, we seek to improve our understanding of how environmental and family conditions impact externalising and internalising symptoms in autistic and non-autistic people. To do this, we conducted analyses with two cohorts in very different settings - in Europe and South Africa - to ensure our findings are globally representative. We used advanced statistical methods to establish environmental and family conditions that were similar to each other, and which could be combined into specific 'factors'. We found that four similar 'factors' could be identified in the two cohorts. These were distinguished by personal characteristics and environmental conditions of individuals, and were named Person Characteristics, Family System, Parental and Material Resources. Interestingly, just 'Family System' was associated with internalising and externalising symptoms, and this was the same in both cohorts. We also found that having high traits of autism impacted this relationship between Family System and mental health conditions with opposite directions in the two settings. These results show that characteristics in the Family System are associated with internalising and externalising symptoms, and autistic persons are particularly impacted, reinforcing the notion that family stressors are important to consider when implementing policy and practice related to improving the mental health of autistic people. En ligne : https://dx.doi.org/10.1177/13623613231200297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=527 Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study / James FINDON in Autism Research, 9-12 (December 2016)
[article]
Titre : Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : James FINDON, Auteur ; Tim CADMAN, Auteur ; Catherine S. STEWART, Auteur ; Emma WOODHOUSE, Auteur ; Hanna EKLUND, Auteur ; Hannah HAYWARD, Auteur ; Daniel DE LE HARPE GOLDEN, Auteur ; Eddie CHAPLIN, Auteur ; Karen GLASER, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Patrick BOLTON, Auteur ; Fiona S. MCEWEN, Auteur Article en page(s) : p.1353-1363 Langues : Anglais (eng) Mots-clés : autism spectrum disorder co-occurring disorder co-morbid disorder hyperactivity attention deficit hyperactivity disorder anxiety depression obsessive–compulsive disorder Index. décimale : PER Périodiques Résumé : Adolescents and adults with autism spectrum disorder (ASD) are at elevated risk of co-occurring mental health problems. These are often undiagnosed, can cause significant impairment, and place a very high burden on family and carers. Detecting co-occurring disorders is extremely important. However, there is no validated screening tool for this purpose. The aim of this pilot study is to test the utility of the strengths and difficulties questionnaire (SDQ) to screen for co-occurring emotional disorders and hyperactivity in adolescents and adults with ASD. The SDQ was completed by 126 parents and 98 individuals with ASD (in 79 cases both parent and self-report were available from the same families). Inter-rater reliability, test-retest stability, internal consistency, and construct validity were examined. SDQ subscales were also compared to clinically utilized measures of emotional disorders and hyperactivity to establish the ability to predict risk of disorder. Inter-rater reliability (r?=?0.42), test-retest stability (r?=?0.64), internal consistency (??=?0.52–0.81) and construct validity (r?=?0.42–0.57) for the SDQ subscales were comparable to general population samples. Parent- and self-report SDQ subscales were significantly associated with measures of anxiety, depression and hyperactivity (62–74% correctly classified). Parent-report performed significantly better than self-report; adults with ASD under-reported difficulties. The SDQ shows promise as a simple and efficient way to screen for emotional disorders and hyperactivity in adolescents and adults with ASD that could help reduce the impact of these disorders on individuals and their families. However, further more systematic attempts at validation are warranted. En ligne : http://dx.doi.org/10.1002/aur.1625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Autism Research > 9-12 (December 2016) . - p.1353-1363[article] Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study [Texte imprimé et/ou numérique] / James FINDON, Auteur ; Tim CADMAN, Auteur ; Catherine S. STEWART, Auteur ; Emma WOODHOUSE, Auteur ; Hanna EKLUND, Auteur ; Hannah HAYWARD, Auteur ; Daniel DE LE HARPE GOLDEN, Auteur ; Eddie CHAPLIN, Auteur ; Karen GLASER, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Patrick BOLTON, Auteur ; Fiona S. MCEWEN, Auteur . - p.1353-1363.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1353-1363
Mots-clés : autism spectrum disorder co-occurring disorder co-morbid disorder hyperactivity attention deficit hyperactivity disorder anxiety depression obsessive–compulsive disorder Index. décimale : PER Périodiques Résumé : Adolescents and adults with autism spectrum disorder (ASD) are at elevated risk of co-occurring mental health problems. These are often undiagnosed, can cause significant impairment, and place a very high burden on family and carers. Detecting co-occurring disorders is extremely important. However, there is no validated screening tool for this purpose. The aim of this pilot study is to test the utility of the strengths and difficulties questionnaire (SDQ) to screen for co-occurring emotional disorders and hyperactivity in adolescents and adults with ASD. The SDQ was completed by 126 parents and 98 individuals with ASD (in 79 cases both parent and self-report were available from the same families). Inter-rater reliability, test-retest stability, internal consistency, and construct validity were examined. SDQ subscales were also compared to clinically utilized measures of emotional disorders and hyperactivity to establish the ability to predict risk of disorder. Inter-rater reliability (r?=?0.42), test-retest stability (r?=?0.64), internal consistency (??=?0.52–0.81) and construct validity (r?=?0.42–0.57) for the SDQ subscales were comparable to general population samples. Parent- and self-report SDQ subscales were significantly associated with measures of anxiety, depression and hyperactivity (62–74% correctly classified). Parent-report performed significantly better than self-report; adults with ASD under-reported difficulties. The SDQ shows promise as a simple and efficient way to screen for emotional disorders and hyperactivity in adolescents and adults with ASD that could help reduce the impact of these disorders on individuals and their families. However, further more systematic attempts at validation are warranted. En ligne : http://dx.doi.org/10.1002/aur.1625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project / Carolin MOESSNANG in Molecular Autism, 11 (2020)
[article]
Titre : Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : Carolin MOESSNANG, Auteur ; Sarah BAUMEISTER, Auteur ; Julian TILLMANN, Auteur ; David GOYARD, Auteur ; Tony CHARMAN, Auteur ; Sara AMBROSINO, Auteur ; Simon BARON-COHEN, Auteur ; Christian F. BECKMANN, Auteur ; Sven BÖLTE, Auteur ; Carsten BOURS, Auteur ; Daisy CRAWLEY, Auteur ; Flavio DELL'ACQUA, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Vincent FROUIN, Auteur ; Hannah HAYWARD, Auteur ; Rosemary HOLT, Auteur ; Mark H. JOHNSON, Auteur ; Emily JONES, Auteur ; Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Luke MASON, Auteur ; Marianne OLDENHINKEL, Auteur ; Antonio PERSICO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Will SPOOREN, Auteur ; Eva LOTH, Auteur ; Declan G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur Article en page(s) : 17 p. Langues : Anglais (eng) Mots-clés : Animated shapes Autism Autism spectrum disorder Development Mentalizing Multi-site Social brain Theory of mind fMRI Science, Atheneum Partners, Blueprint Partnership, Boehringer Ingelheim, Daimler und Benz Stiftung, Elsevier, F. Hoffmann-La Roche, ICARE Schizophrenia, K. G. Jebsen Foundation, L.E.K Consulting, Lundbeck International Foundation (LINF), R. Adamczak, Roche Pharma, Science Foundation, Sumitomo Dainippon Pharma, Synapsis Foundation–Alzheimer Research Switzerland, and System Analytics, and has received lectures fees including travel fees from Boehringer Ingelheim, Fama Public Relations, Institut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Janssen-Cilag, Klinikum Christophsbad, Göppingen, Lilly Deutschland, Luzerner Psychiatrie, LVR Klinikum Düsseldorf, LWL Psychiatrie Verbund Westfalen-Lippe, Otsuka Pharmaceuticals, Reunions i Ciencia S. L., Spanish Society of Psychiatry, Südwestrundfunk Fernsehen, Stern TV, and Vitos Klinikum Kurhessen. WM has received lecture or travel fees from Pfizer, Grünenthal, University of Zürich, International Association for the Study on Pain (IASP), and European Federation of IASP Chapters (EFIC). SB discloses that he has in the last 5?years acted as an author, consultant or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Ability Partner, Kompetento, Expo Medica, Clarion Healthcare, and Prophase. He receives royalties for textbooks and diagnostic tools from Huber/Hogrefe, Kohlhammer, and UTB. The other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD. METHODS: As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189) aged 6 to 30?years. We presented an animated shapes task to assess and comprehensively characterize social brain activation during mentalizing. We tested for effects of age, diagnosis, and their association with symptom measures, including a continuous measure of autistic traits. RESULTS: We observed robust effects of task. Within the ASD sample, autistic traits were moderately associated with functional activation in one of the key regions of the social brain, the dorsomedial prefrontal cortex. However, there were no significant effects of diagnosis on task performance and no effects of age and diagnosis on social brain responses. Besides a lack of mean group differences, our data provide no evidence for meaningful differences in the distribution of brain response measures. Extensive control analyses suggest that the lack of case-control differences was not due to a variety of potential confounders. CONCLUSIONS: Contrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition. En ligne : http://dx.doi.org/10.1186/s13229-020-0317-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 17 p.[article] Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project [Texte imprimé et/ou numérique] / Carolin MOESSNANG, Auteur ; Sarah BAUMEISTER, Auteur ; Julian TILLMANN, Auteur ; David GOYARD, Auteur ; Tony CHARMAN, Auteur ; Sara AMBROSINO, Auteur ; Simon BARON-COHEN, Auteur ; Christian F. BECKMANN, Auteur ; Sven BÖLTE, Auteur ; Carsten BOURS, Auteur ; Daisy CRAWLEY, Auteur ; Flavio DELL'ACQUA, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Vincent FROUIN, Auteur ; Hannah HAYWARD, Auteur ; Rosemary HOLT, Auteur ; Mark H. JOHNSON, Auteur ; Emily JONES, Auteur ; Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Luke MASON, Auteur ; Marianne OLDENHINKEL, Auteur ; Antonio PERSICO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Will SPOOREN, Auteur ; Eva LOTH, Auteur ; Declan G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur . - 17 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 17 p.
Mots-clés : Animated shapes Autism Autism spectrum disorder Development Mentalizing Multi-site Social brain Theory of mind fMRI Science, Atheneum Partners, Blueprint Partnership, Boehringer Ingelheim, Daimler und Benz Stiftung, Elsevier, F. Hoffmann-La Roche, ICARE Schizophrenia, K. G. Jebsen Foundation, L.E.K Consulting, Lundbeck International Foundation (LINF), R. Adamczak, Roche Pharma, Science Foundation, Sumitomo Dainippon Pharma, Synapsis Foundation–Alzheimer Research Switzerland, and System Analytics, and has received lectures fees including travel fees from Boehringer Ingelheim, Fama Public Relations, Institut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Janssen-Cilag, Klinikum Christophsbad, Göppingen, Lilly Deutschland, Luzerner Psychiatrie, LVR Klinikum Düsseldorf, LWL Psychiatrie Verbund Westfalen-Lippe, Otsuka Pharmaceuticals, Reunions i Ciencia S. L., Spanish Society of Psychiatry, Südwestrundfunk Fernsehen, Stern TV, and Vitos Klinikum Kurhessen. WM has received lecture or travel fees from Pfizer, Grünenthal, University of Zürich, International Association for the Study on Pain (IASP), and European Federation of IASP Chapters (EFIC). SB discloses that he has in the last 5?years acted as an author, consultant or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Ability Partner, Kompetento, Expo Medica, Clarion Healthcare, and Prophase. He receives royalties for textbooks and diagnostic tools from Huber/Hogrefe, Kohlhammer, and UTB. The other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD. METHODS: As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189) aged 6 to 30?years. We presented an animated shapes task to assess and comprehensively characterize social brain activation during mentalizing. We tested for effects of age, diagnosis, and their association with symptom measures, including a continuous measure of autistic traits. RESULTS: We observed robust effects of task. Within the ASD sample, autistic traits were moderately associated with functional activation in one of the key regions of the social brain, the dorsomedial prefrontal cortex. However, there were no significant effects of diagnosis on task performance and no effects of age and diagnosis on social brain responses. Besides a lack of mean group differences, our data provide no evidence for meaningful differences in the distribution of brain response measures. Extensive control analyses suggest that the lack of case-control differences was not due to a variety of potential confounders. CONCLUSIONS: Contrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition. En ligne : http://dx.doi.org/10.1186/s13229-020-0317-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Unique dynamic profiles of social attention in autistic females / Teresa DEL BIANCO in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
[article]
Titre : Unique dynamic profiles of social attention in autistic females Type de document : Texte imprimé et/ou numérique Auteurs : Teresa DEL BIANCO, Auteur ; Luke MASON, Auteur ; Meng-Chuan LAI, Auteur ; Eva LOTH, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Hannah HAYWARD, Auteur ; Teresa GLEISSL, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G. M. MURPHY, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur Article en page(s) : p.1602-1614 Langues : Anglais (eng) Mots-clés : Female Humans Attention Autistic Disorder/diagnosis Cohort Studies Learning Sex Characteristics Child Adolescent Young Adult Adult Autism eye-tracking male sex differences social attention Index. décimale : PER Périodiques Résumé : BACKGROUND: Social attention affords learning opportunities across development and may contribute to individual differences in developmental trajectories, such as between male and female individuals, and in neurodevelopmental conditions, such as autism. METHODS: Using eye-tracking, we measured social attention in a large cohort of autistic (n=123) and nonautistic females (n=107), and autistic (n=330) and nonautistic males (n=204), aged 6-30 years. Using mixed Growth Curve Analysis, we modelled sex and diagnostic effects on the temporal dynamics of proportional looking time to three types of social stimuli (lean-static, naturalistic-static, and naturalistic-dynamic) and examined the link between individual differences and dimensional social and nonsocial autistic traits in autistic females and males. RESULTS: In the lean-static stimulus, average face-looking was higher in females than in males of both autistic and nonautistic groups. Differences in the dynamic pattern of face-looking were seen in autistic vs. nonautistic females, but not males, with face-looking peaking later in the trial in autistic females. In the naturalistic-dynamic stimulus, average face-looking was higher in females than in males of both groups; changes in the dynamic pattern of face looking were seen in autistic vs. nonautistic males, but not in females, with a steeper peak in nonautistic males. Lower average face-looking was associated with higher observer-measured autistic characteristics in autistic females, but not in males. CONCLUSIONS: Overall, we found stronger social attention in females to a similar degree in both autistic and nonautistic groups. Nonetheless, the dynamic profiles of social attention differed in different ways in autistic females and males compared to their nonautistic peers, and autistic traits predicted trends of average face-looking in autistic females. These findings support the role of social attention in the emergence of sex-related differences in autistic characteristics, suggesting an avenue to phenotypic stratification. En ligne : http://dx.doi.org/10.1111/jcpp.13630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1602-1614[article] Unique dynamic profiles of social attention in autistic females [Texte imprimé et/ou numérique] / Teresa DEL BIANCO, Auteur ; Luke MASON, Auteur ; Meng-Chuan LAI, Auteur ; Eva LOTH, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Hannah HAYWARD, Auteur ; Teresa GLEISSL, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G. M. MURPHY, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur . - p.1602-1614.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1602-1614
Mots-clés : Female Humans Attention Autistic Disorder/diagnosis Cohort Studies Learning Sex Characteristics Child Adolescent Young Adult Adult Autism eye-tracking male sex differences social attention Index. décimale : PER Périodiques Résumé : BACKGROUND: Social attention affords learning opportunities across development and may contribute to individual differences in developmental trajectories, such as between male and female individuals, and in neurodevelopmental conditions, such as autism. METHODS: Using eye-tracking, we measured social attention in a large cohort of autistic (n=123) and nonautistic females (n=107), and autistic (n=330) and nonautistic males (n=204), aged 6-30 years. Using mixed Growth Curve Analysis, we modelled sex and diagnostic effects on the temporal dynamics of proportional looking time to three types of social stimuli (lean-static, naturalistic-static, and naturalistic-dynamic) and examined the link between individual differences and dimensional social and nonsocial autistic traits in autistic females and males. RESULTS: In the lean-static stimulus, average face-looking was higher in females than in males of both autistic and nonautistic groups. Differences in the dynamic pattern of face-looking were seen in autistic vs. nonautistic females, but not males, with face-looking peaking later in the trial in autistic females. In the naturalistic-dynamic stimulus, average face-looking was higher in females than in males of both groups; changes in the dynamic pattern of face looking were seen in autistic vs. nonautistic males, but not in females, with a steeper peak in nonautistic males. Lower average face-looking was associated with higher observer-measured autistic characteristics in autistic females, but not in males. CONCLUSIONS: Overall, we found stronger social attention in females to a similar degree in both autistic and nonautistic groups. Nonetheless, the dynamic profiles of social attention differed in different ways in autistic females and males compared to their nonautistic peers, and autistic traits predicted trends of average face-looking in autistic females. These findings support the role of social attention in the emergence of sex-related differences in autistic characteristics, suggesting an avenue to phenotypic stratification. En ligne : http://dx.doi.org/10.1111/jcpp.13630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490