Atypical Tactile Perception in Early Childhood Autism / Svenja ESPENHAHN in Journal of Autism and Developmental Disorders, 53-7 (July 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2891-2904 Titre : Atypical Tactile Perception in Early Childhood Autism Type de document : Texte imprimé et/ou numérique Auteurs : Svenja ESPENHAHN, Auteur ; Kate J. GODFREY, Auteur ; Sakshi KAUR, Auteur ; Carly MCMORRIS, Auteur ; Kara MURIAS, Auteur ; Mark TOMMERDAHL, Auteur ; Signe BRAY, Auteur ; Ashley D. HARRIS, Auteur Article en page(s) : p.2891-2904 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We assessed different aspects of tactile perception in young children (3-6 years) with autism. Autistic and neurotypical children completed vibrotactile tasks assessing reaction time, amplitude discrimination (sequential and simultaneous) and temporal discrimination (temporal order judgment and duration discrimination). Autistic children had elevated and more variable reaction times, suggesting slower perceptual-motor processing speed and/or greater distractibility. Children with autism also showed higher amplitude discrimination and temporal order judgement thresholds compared to neurotypical children. Tactile perceptual metrics did not associate with social or tactile sensitivities measured by parent-reports. Altered tactile behavioral responses appear in early childhood, can be quantified but appear dissociated from sensitivity. This implies these measures are complementary, but not necessarily related, phenomena of atypical tactile perception in autism. En ligne : https://doi.org/10.1007/s10803-022-05570-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Atypical Tactile Perception in Early Childhood Autism [Texte imprimé et/ou numérique] / Svenja ESPENHAHN, Auteur ; Kate J. GODFREY, Auteur ; Sakshi KAUR, Auteur ; Carly MCMORRIS, Auteur ; Kara MURIAS, Auteur ; Mark TOMMERDAHL, Auteur ; Signe BRAY, Auteur ; Ashley D. HARRIS, Auteur . - p.2891-2904. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2891-2904 Index. décimale : PER Périodiques Résumé : We assessed different aspects of tactile perception in young children (3-6 years) with autism. Autistic and neurotypical children completed vibrotactile tasks assessing reaction time, amplitude discrimination (sequential and simultaneous) and temporal discrimination (temporal order judgment and duration discrimination). Autistic children had elevated and more variable reaction times, suggesting slower perceptual-motor processing speed and/or greater distractibility. Children with autism also showed higher amplitude discrimination and temporal order judgement thresholds compared to neurotypical children. Tactile perceptual metrics did not associate with social or tactile sensitivities measured by parent-reports. Altered tactile behavioral responses appear in early childhood, can be quantified but appear dissociated from sensitivity. This implies these measures are complementary, but not necessarily related, phenomena of atypical tactile perception in autism. En ligne : https://doi.org/10.1007/s10803-022-05570-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Reduced GABA and altered somatosensory function in children with autism spectrum disorder / Nicolaas A. J. PUTS in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.608-619 Titre : Reduced GABA and altered somatosensory function in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur Article en page(s) : p.608-619 Langues : Anglais (eng) Mots-clés : autism  somatosensory  GABA  magnetic resonance spectroscopy  tactile  MRS  touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Reduced GABA and altered somatosensory function in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur . - p.608-619. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.608-619 Mots-clés : autism  somatosensory  GABA  magnetic resonance spectroscopy  tactile  MRS  touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

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