Dépouillements

Issue Information in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.567-571 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.567-571 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1697 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Issue Information [Texte imprimé et/ou numérique] . - p.567-571. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.567-571 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1697 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Hyperactivity and male-specific sleep deficits in the 16p11.2 deletion mouse model of autism / Christopher C. ANGELAKOS in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.572-584 Titre : Hyperactivity and male-specific sleep deficits in the 16p11.2 deletion mouse model of autism Type de document : Texte imprimé et/ou numérique Auteurs : Christopher C. ANGELAKOS, Auteur ; Adam J. WATSON, Auteur ; W. Timothy O'BRIEN, Auteur ; Kyle S. KRAINOCK, Auteur ; Thomas NICKL-JOCKSCHAT, Auteur ; Ted ABEL, Auteur Article en page(s) : p.572-584 Langues : Anglais (eng) Mots-clés : autism  sleep  sex differences  ADHD  16p11.2 deletion  copy number variation Index. décimale : PER Périodiques Résumé : Sleep disturbances and hyperactivity are prevalent in several neurodevelopmental disorders, including autism spectrum disorders (ASDs) and attention deficit-hyperactivity disorder (ADHD). Evidence from genome-wide association studies indicates that chromosomal copy number variations (CNVs) are associated with increased prevalence of these neurodevelopmental disorders. In particular, CNVs in chromosomal region 16p11.2 profoundly increase the risk for ASD and ADHD, disorders that are more common in males than females. We hypothesized that mice hemizygous for the 16p11.2 deletion (16p11.2 del/+) would exhibit sex-specific sleep and activity alterations. To test this hypothesis, we recorded activity patterns using infrared beam breaks in the home-cage of adult male and female 16p11.2 del/+ and wildtype (WT) littermates. In comparison to controls, we found that both male and female 16p11.2 del/+ mice exhibited robust home-cage hyperactivity. In additional experiments, sleep was assessed by polysomnography over a 24-hr period. 16p11.2 del/+ male, but not female mice, exhibited significantly more time awake and significantly less time in non-rapid-eye-movement (NREM) sleep during the 24-hr period than wildtype littermates. Analysis of bouts of sleep and wakefulness revealed that 16p11.2 del/+ males, but not females, spent a significantly greater proportion of wake time in long bouts of consolidated wakefulness (greater than 42 min in duration) compared to controls. These changes in hyperactivity, wake time, and wake time distribution in the males resemble sleep disturbances observed in human ASD and ADHD patients, suggesting that the 16p11.2 del/+ mouse model may be a useful genetic model for studying sleep and activity problems in human neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Hyperactivity and male-specific sleep deficits in the 16p11.2 deletion mouse model of autism [Texte imprimé et/ou numérique] / Christopher C. ANGELAKOS, Auteur ; Adam J. WATSON, Auteur ; W. Timothy O'BRIEN, Auteur ; Kyle S. KRAINOCK, Auteur ; Thomas NICKL-JOCKSCHAT, Auteur ; Ted ABEL, Auteur . - p.572-584. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.572-584 Mots-clés : autism  sleep  sex differences  ADHD  16p11.2 deletion  copy number variation Index. décimale : PER Périodiques Résumé : Sleep disturbances and hyperactivity are prevalent in several neurodevelopmental disorders, including autism spectrum disorders (ASDs) and attention deficit-hyperactivity disorder (ADHD). Evidence from genome-wide association studies indicates that chromosomal copy number variations (CNVs) are associated with increased prevalence of these neurodevelopmental disorders. In particular, CNVs in chromosomal region 16p11.2 profoundly increase the risk for ASD and ADHD, disorders that are more common in males than females. We hypothesized that mice hemizygous for the 16p11.2 deletion (16p11.2 del/+) would exhibit sex-specific sleep and activity alterations. To test this hypothesis, we recorded activity patterns using infrared beam breaks in the home-cage of adult male and female 16p11.2 del/+ and wildtype (WT) littermates. In comparison to controls, we found that both male and female 16p11.2 del/+ mice exhibited robust home-cage hyperactivity. In additional experiments, sleep was assessed by polysomnography over a 24-hr period. 16p11.2 del/+ male, but not female mice, exhibited significantly more time awake and significantly less time in non-rapid-eye-movement (NREM) sleep during the 24-hr period than wildtype littermates. Analysis of bouts of sleep and wakefulness revealed that 16p11.2 del/+ males, but not females, spent a significantly greater proportion of wake time in long bouts of consolidated wakefulness (greater than 42 min in duration) compared to controls. These changes in hyperactivity, wake time, and wake time distribution in the males resemble sleep disturbances observed in human ASD and ADHD patients, suggesting that the 16p11.2 del/+ mouse model may be a useful genetic model for studying sleep and activity problems in human neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Neonatal thyroid hormone levels in association with autism spectrum disorder / Kristen LYALL in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.585-592 Titre : Neonatal thyroid hormone levels in association with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur ; Gayle C. WINDHAM, Auteur Article en page(s) : p.585-592 Langues : Anglais (eng) Mots-clés : risk factors  thyroid hormones  autism spectrum disorder  neonatal hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones (TH) are critical in early neurodevelopment, but few studies have examined whether neonatal TH levels influence risk of autism spectrum disorder (ASD). This study linked California neonatal screening data with live birth and Department of Developmental Services records to examine newborn TH levels in relation to ASD. Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were measured in newborn bloodspots as part of routine screening, in 1996 and 2002, respectively. Mean levels of T4 and TSH were compared between ASD cases and non-cases. Four hundred forty-seven thousand, fifty-nine screened, singleton births from 1996 and 446,424 from 2002 were examined, including 4,818 ASD cases. Binomial regression, using categories of T4 and TSH percentiles was used to calculate crude and adjusted risk ratios (RR). Covariates included maternal and child factors, gestational age, and age at blood draw. No significant associations were found with TSH levels and ASD in crude or adjusted analyses. ASD cases had significantly lower mean T4 levels than non-cases, but this association was no longer significant in adjusted analyses (RR in individuals in lowest 5th percentile of T4 levels?=?1.13, 95% 0.93–1.37). However, this association appeared stronger in certain subgroup analyses, particularly among neonates with blood draw ?48 hr from birth (RR?=?1.67, 95% CI 1.08, 2.60), when TH levels become more stable. Thus, results from this large, population-based study did not suggest strong associations between neonatal TH and ASD, but certain subgroups of newborns with the lowest T4 levels may have modestly increased ASD risk. En ligne : http://dx.doi.org/10.1002/aur.1708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Neonatal thyroid hormone levels in association with autism spectrum disorder [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur ; Gayle C. WINDHAM, Auteur . - p.585-592. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.585-592 Mots-clés : risk factors  thyroid hormones  autism spectrum disorder  neonatal hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones (TH) are critical in early neurodevelopment, but few studies have examined whether neonatal TH levels influence risk of autism spectrum disorder (ASD). This study linked California neonatal screening data with live birth and Department of Developmental Services records to examine newborn TH levels in relation to ASD. Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were measured in newborn bloodspots as part of routine screening, in 1996 and 2002, respectively. Mean levels of T4 and TSH were compared between ASD cases and non-cases. Four hundred forty-seven thousand, fifty-nine screened, singleton births from 1996 and 446,424 from 2002 were examined, including 4,818 ASD cases. Binomial regression, using categories of T4 and TSH percentiles was used to calculate crude and adjusted risk ratios (RR). Covariates included maternal and child factors, gestational age, and age at blood draw. No significant associations were found with TSH levels and ASD in crude or adjusted analyses. ASD cases had significantly lower mean T4 levels than non-cases, but this association was no longer significant in adjusted analyses (RR in individuals in lowest 5th percentile of T4 levels?=?1.13, 95% 0.93–1.37). However, this association appeared stronger in certain subgroup analyses, particularly among neonates with blood draw ?48 hr from birth (RR?=?1.67, 95% CI 1.08, 2.60), when TH levels become more stable. Thus, results from this large, population-based study did not suggest strong associations between neonatal TH and ASD, but certain subgroups of newborns with the lowest T4 levels may have modestly increased ASD risk. En ligne : http://dx.doi.org/10.1002/aur.1708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD / Russell G. PORT in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.593-607 Titre : Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Russell G. PORT, Auteur ; William GAETZ, Auteur ; Luke BLOY, Auteur ; Dah-Jyuu WANG, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Susan E. LEVY, Auteur ; Edward S. BRODKIN, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.593-607 Langues : Anglais (eng) Mots-clés : magnetoencephalography  gamma-band  GABA  MEGA-PRESS  magnetic resonance spectroscopy  auditory  autism spectrum disorder  excitatory/inhibitory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD and also corresponding rodent models. One neural process thought to be reliant on E/I balance is gamma-band activity (Gamma), with support arising from observed correlations between motor, as well as visual, Gamma and underlying GABA concentrations in healthy adults. Additionally, decreased Gamma has been observed in ASD individuals and relevant animal models, though the direct relationship between Gamma and GABA concentrations in ASD remains unexplored. This study combined magnetoencephalography (MEG) and edited magnetic resonance spectroscopy (MRS) in 27 typically developing individuals (TD) and 30 individuals with ASD. Auditory cortex localized phase-locked Gamma was compared to resting Superior Temporal Gyrus relative cortical GABA concentrations for both children/adolescents and adults. Children/adolescents with ASD exhibited significantly decreased GABA+/Creatine (Cr) levels, though typical Gamma. Additionally, these children/adolescents lacked the typical maturation of GABA+/Cr concentrations and gamma-band coherence. Furthermore, children/adolescents with ASD additionally failed to exhibit the typical GABA+/Cr to gamma-band coherence association. This altered coupling during childhood/adolescence may result in Gamma decreases observed in the adults with ASD. Therefore, individuals with ASD exhibit improper local neuronal circuitry maturation during a childhood/adolescence critical period, when GABA is involved in configuring of such circuit functioning. Provocatively a novel line of treatment is suggested (with a critical time window); by increasing neural GABA levels in children/adolescents with ASD, proper local circuitry maturation may be restored resulting in typical Gamma in adulthood. En ligne : http://dx.doi.org/10.1002/aur.1686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD [Texte imprimé et/ou numérique] / Russell G. PORT, Auteur ; William GAETZ, Auteur ; Luke BLOY, Auteur ; Dah-Jyuu WANG, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Susan E. LEVY, Auteur ; Edward S. BRODKIN, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.593-607. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.593-607 Mots-clés : magnetoencephalography  gamma-band  GABA  MEGA-PRESS  magnetic resonance spectroscopy  auditory  autism spectrum disorder  excitatory/inhibitory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD and also corresponding rodent models. One neural process thought to be reliant on E/I balance is gamma-band activity (Gamma), with support arising from observed correlations between motor, as well as visual, Gamma and underlying GABA concentrations in healthy adults. Additionally, decreased Gamma has been observed in ASD individuals and relevant animal models, though the direct relationship between Gamma and GABA concentrations in ASD remains unexplored. This study combined magnetoencephalography (MEG) and edited magnetic resonance spectroscopy (MRS) in 27 typically developing individuals (TD) and 30 individuals with ASD. Auditory cortex localized phase-locked Gamma was compared to resting Superior Temporal Gyrus relative cortical GABA concentrations for both children/adolescents and adults. Children/adolescents with ASD exhibited significantly decreased GABA+/Creatine (Cr) levels, though typical Gamma. Additionally, these children/adolescents lacked the typical maturation of GABA+/Cr concentrations and gamma-band coherence. Furthermore, children/adolescents with ASD additionally failed to exhibit the typical GABA+/Cr to gamma-band coherence association. This altered coupling during childhood/adolescence may result in Gamma decreases observed in the adults with ASD. Therefore, individuals with ASD exhibit improper local neuronal circuitry maturation during a childhood/adolescence critical period, when GABA is involved in configuring of such circuit functioning. Provocatively a novel line of treatment is suggested (with a critical time window); by increasing neural GABA levels in children/adolescents with ASD, proper local circuitry maturation may be restored resulting in typical Gamma in adulthood. En ligne : http://dx.doi.org/10.1002/aur.1686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Reduced GABA and altered somatosensory function in children with autism spectrum disorder / Nicolaas A. J. PUTS in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.608-619 Titre : Reduced GABA and altered somatosensory function in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur Article en page(s) : p.608-619 Langues : Anglais (eng) Mots-clés : autism  somatosensory  GABA  magnetic resonance spectroscopy  tactile  MRS  touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Reduced GABA and altered somatosensory function in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur . - p.608-619. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.608-619 Mots-clés : autism  somatosensory  GABA  magnetic resonance spectroscopy  tactile  MRS  touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Diagnostic model generated by MRI-derived brain features in toddlers with autism spectrum disorder / Xiang XIAO in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.620-630 Titre : Diagnostic model generated by MRI-derived brain features in toddlers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xiang XIAO, Auteur ; Hui FANG, Auteur ; Jiansheng WU, Auteur ; ChaoYong XIAO, Auteur ; Ting XIAO, Auteur ; Lu QIAN, Auteur ; Fengjing LIANG, Auteur ; Zhou XIAO, Auteur ; Kangkang CHU, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.620-630 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  toddler  magnetic resonance imaging  cortical thickness  predictive model Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder mainly showed atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests and activities. Now clinic diagnosis of ASD is mostly based on psychological evaluation, clinical observation and medical history. All these behavioral indexes could not avoid defects such as subjectivity and reporter-dependency. Therefore researchers devoted themselves to seek relatively stable biomarkers of ASD as supplementary diagnostic evidence. The goal of present study is to generate relatively stable predictive model based on anatomical brain features by using machine learning technique. Forty-six ASD children and thirty-nine development delay children aged from 18 to 37 months were evolved in. As a result, the predictive model generated by regional average cortical thickness of regions with top 20 highest importance of random forest classifier showed best diagnostic performance. And random forest was proved to be the optimal approach for neuroimaging data mining in small size set and thickness-based classification outperformed volume-based classification and surface area-based classification in ASD. The brain regions selected by the models might attract attention and the idea of considering biomarkers as a supplementary evidence of ASD diagnosis worth exploring. En ligne : http://dx.doi.org/10.1002/aur.1711 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Diagnostic model generated by MRI-derived brain features in toddlers with autism spectrum disorder [Texte imprimé et/ou numérique] / Xiang XIAO, Auteur ; Hui FANG, Auteur ; Jiansheng WU, Auteur ; ChaoYong XIAO, Auteur ; Ting XIAO, Auteur ; Lu QIAN, Auteur ; Fengjing LIANG, Auteur ; Zhou XIAO, Auteur ; Kangkang CHU, Auteur ; Xiaoyan KE, Auteur . - p.620-630. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.620-630 Mots-clés : autism spectrum disorder  toddler  magnetic resonance imaging  cortical thickness  predictive model Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder mainly showed atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests and activities. Now clinic diagnosis of ASD is mostly based on psychological evaluation, clinical observation and medical history. All these behavioral indexes could not avoid defects such as subjectivity and reporter-dependency. Therefore researchers devoted themselves to seek relatively stable biomarkers of ASD as supplementary diagnostic evidence. The goal of present study is to generate relatively stable predictive model based on anatomical brain features by using machine learning technique. Forty-six ASD children and thirty-nine development delay children aged from 18 to 37 months were evolved in. As a result, the predictive model generated by regional average cortical thickness of regions with top 20 highest importance of random forest classifier showed best diagnostic performance. And random forest was proved to be the optimal approach for neuroimaging data mining in small size set and thickness-based classification outperformed volume-based classification and surface area-based classification in ASD. The brain regions selected by the models might attract attention and the idea of considering biomarkers as a supplementary evidence of ASD diagnosis worth exploring. En ligne : http://dx.doi.org/10.1002/aur.1711 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder / Fahimeh MAMASHLI in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.631-647 Titre : Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Hari BHARADWAJ, Auteur ; Konstantinos MICHMIZOS, Auteur ; Santosh GANESAN, Auteur ; Keri-Lee A. GAREL, Auteur ; Javeria ALI HASHMI, Auteur ; Martha R. HERBERT, Auteur ; Matti HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.631-647 Langues : Anglais (eng) Mots-clés : autism  MEG  auditory  noise  connectivity  feedback  top-down Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations. In the quiet condition, we found common neural sources of the MMF response in both groups, in the right temporal gyrus and inferior frontal gyrus (IFG). In the noise condition, the MMF response in the right IFG was preserved in the TD group, but reduced relative to the quiet condition in ASD group. The MMF response in the right IFG also correlated with severity of ASD. Moreover, in noise, we found significantly reduced normalized coherence (deviant normalized by standard) in ASD relative to TD, in the beta band (14–25 Hz), between left temporal and left inferior frontal sub-regions. However, unnormalized coherence (coherence during deviant or standard) was significantly increased in ASD relative to TD, in multiple frequency bands. Our findings suggest increased recruitment of neural resources in ASD irrespective of the task difficulty, alongside a reduction in top-down modulations, usually mediated by the beta band, needed to mitigate the impact of noise on auditory processing. En ligne : http://dx.doi.org/10.1002/aur.1714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder [Texte imprimé et/ou numérique] / Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Hari BHARADWAJ, Auteur ; Konstantinos MICHMIZOS, Auteur ; Santosh GANESAN, Auteur ; Keri-Lee A. GAREL, Auteur ; Javeria ALI HASHMI, Auteur ; Martha R. HERBERT, Auteur ; Matti HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.631-647. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.631-647 Mots-clés : autism  MEG  auditory  noise  connectivity  feedback  top-down Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations. In the quiet condition, we found common neural sources of the MMF response in both groups, in the right temporal gyrus and inferior frontal gyrus (IFG). In the noise condition, the MMF response in the right IFG was preserved in the TD group, but reduced relative to the quiet condition in ASD group. The MMF response in the right IFG also correlated with severity of ASD. Moreover, in noise, we found significantly reduced normalized coherence (deviant normalized by standard) in ASD relative to TD, in the beta band (14–25 Hz), between left temporal and left inferior frontal sub-regions. However, unnormalized coherence (coherence during deviant or standard) was significantly increased in ASD relative to TD, in multiple frequency bands. Our findings suggest increased recruitment of neural resources in ASD irrespective of the task difficulty, alongside a reduction in top-down modulations, usually mediated by the beta band, needed to mitigate the impact of noise on auditory processing. En ligne : http://dx.doi.org/10.1002/aur.1714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Dyspraxia in ASD: Impaired coordination of movement elements / Danielle MCAULIFFE in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.648-652 Titre : Dyspraxia in ASD: Impaired coordination of movement elements Type de document : Texte imprimé et/ou numérique Auteurs : Danielle MCAULIFFE, Auteur ; Ajay S. PILLAI, Auteur ; Alyssa TIEDEMANN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.648-652 Langues : Anglais (eng) Mots-clés : dyspraxia  autism  motor planning  divided attention  multiple task interference Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially. There was indeed a group × gesture-type interaction (P? En ligne : http://dx.doi.org/10.1002/aur.1693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Dyspraxia in ASD: Impaired coordination of movement elements [Texte imprimé et/ou numérique] / Danielle MCAULIFFE, Auteur ; Ajay S. PILLAI, Auteur ; Alyssa TIEDEMANN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Joshua B. EWEN, Auteur . - p.648-652. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.648-652 Mots-clés : dyspraxia  autism  motor planning  divided attention  multiple task interference Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially. There was indeed a group × gesture-type interaction (P? En ligne : http://dx.doi.org/10.1002/aur.1693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

“Frank” presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder / Ashley DE MARCHENA in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.653-662 Titre : “Frank” presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ashley DE MARCHENA, Auteur ; Judith MILLER, Auteur Article en page(s) : p.653-662 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  diagnostic decision-making  behavioral phenotype Index. décimale : PER Périodiques Résumé : Many individuals with ASD have a distinctive behavioral presentation that is recognizable within moments, a phenomenon we call “frank” ASD. This phenomenon has been discussed informally for decades, perhaps as “classic” ASD; however, there is no unitary “classic” presentation, and classic autism does not seem to correspond to level of functioning. Thus, neither “frank” nor “classic” autism has been delineated or studied as a research construct. To initiate the empirical study of frank ASD, we surveyed 151 clinicians, from a range of disciplines that diagnose ASD, about this phenomenon. Respondents completed a 13-item questionnaire about frank ASD, which was analyzed using a mixed-methods approach. Ninety-seven percentage of respondents were familiar with the phenomenon. Respondents estimated that 40% of the ASD population has a frank presentation. Respondents reported the most highly specific behaviors associated with frank presentations were a general sense of impaired reciprocity, quality of eye contact, atypical vocal prosody, presence of motor mannerisms, and atypical gait or posture. In general, respondents reported detecting frank features rapidly, with the majority forming their impressions within the first ten minutes of interaction or observation. Although unstudied empirically, “frank” presentations of ASD are familiar to diagnosing clinicians, and appear to be based on behaviors both central to ASD diagnostic criteria (e.g., impaired reciprocity), and absent from diagnostic criteria (e.g., atypical gait or posture). We discuss these findings within the context of diagnostic decision-making and behavioral phenotyping of ASD. En ligne : http://dx.doi.org/10.1002/aur.1706 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] “Frank” presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder [Texte imprimé et/ou numérique] / Ashley DE MARCHENA, Auteur ; Judith MILLER, Auteur . - p.653-662. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.653-662 Mots-clés : autism spectrum disorder  diagnostic decision-making  behavioral phenotype Index. décimale : PER Périodiques Résumé : Many individuals with ASD have a distinctive behavioral presentation that is recognizable within moments, a phenomenon we call “frank” ASD. This phenomenon has been discussed informally for decades, perhaps as “classic” ASD; however, there is no unitary “classic” presentation, and classic autism does not seem to correspond to level of functioning. Thus, neither “frank” nor “classic” autism has been delineated or studied as a research construct. To initiate the empirical study of frank ASD, we surveyed 151 clinicians, from a range of disciplines that diagnose ASD, about this phenomenon. Respondents completed a 13-item questionnaire about frank ASD, which was analyzed using a mixed-methods approach. Ninety-seven percentage of respondents were familiar with the phenomenon. Respondents estimated that 40% of the ASD population has a frank presentation. Respondents reported the most highly specific behaviors associated with frank presentations were a general sense of impaired reciprocity, quality of eye contact, atypical vocal prosody, presence of motor mannerisms, and atypical gait or posture. In general, respondents reported detecting frank features rapidly, with the majority forming their impressions within the first ten minutes of interaction or observation. Although unstudied empirically, “frank” presentations of ASD are familiar to diagnosing clinicians, and appear to be based on behaviors both central to ASD diagnostic criteria (e.g., impaired reciprocity), and absent from diagnostic criteria (e.g., atypical gait or posture). We discuss these findings within the context of diagnostic decision-making and behavioral phenotyping of ASD. En ligne : http://dx.doi.org/10.1002/aur.1706 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Social participation and its relation to internalizing symptoms among youth with autism spectrum disorder as they transition from high school / Julie LOUNDS TAYLOR in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.663-672 Titre : Social participation and its relation to internalizing symptoms among youth with autism spectrum disorder as they transition from high school Type de document : Texte imprimé et/ou numérique Auteurs : Julie LOUNDS TAYLOR, Auteur ; Ryan E. ADAMS, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.663-672 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  transition to adulthood  social participation  internalizing Index. décimale : PER Périodiques Résumé : In the present study, we examined how unstructured (e.g., spending time with friends or co-workers) and structured (e.g., attending social events at a place of workshop, sports teams) social participation changed from before to after high school for youth with autism spectrum disorders (ASD), as well as the longitudinal and concurrent relations between social participation and internalizing symptoms. Participants included 36 families of youth with ASD who were all in their last year of high school at the first time point of data collection, and who were out of high school for an average of 9 months at the second time point. Social participation and internalizing symptoms were determined using parental report. There was no average change in the amount of unstructured social participation after high school exit, although substantial individual variability was observed. Participation in structured social activities significantly declined after high school exit. Youth who had more structured social participation while in high school were significantly more likely to have gains in their unstructured social participation after high school exit. Turning to relationships between internalizing and social activities, more internalizing symptoms while youth with ASD were in high school significantly predicted increasing social isolation after high school exit (both in terms of structured and unstructured activities). Results point to the likely need for additional supports during the transition to adulthood for youth with ASD who have internalizing problems. En ligne : http://dx.doi.org/10.1002/aur.1709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Social participation and its relation to internalizing symptoms among youth with autism spectrum disorder as they transition from high school [Texte imprimé et/ou numérique] / Julie LOUNDS TAYLOR, Auteur ; Ryan E. ADAMS, Auteur ; Somer L. BISHOP, Auteur . - p.663-672. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.663-672 Mots-clés : autism spectrum disorder  transition to adulthood  social participation  internalizing Index. décimale : PER Périodiques Résumé : In the present study, we examined how unstructured (e.g., spending time with friends or co-workers) and structured (e.g., attending social events at a place of workshop, sports teams) social participation changed from before to after high school for youth with autism spectrum disorders (ASD), as well as the longitudinal and concurrent relations between social participation and internalizing symptoms. Participants included 36 families of youth with ASD who were all in their last year of high school at the first time point of data collection, and who were out of high school for an average of 9 months at the second time point. Social participation and internalizing symptoms were determined using parental report. There was no average change in the amount of unstructured social participation after high school exit, although substantial individual variability was observed. Participation in structured social activities significantly declined after high school exit. Youth who had more structured social participation while in high school were significantly more likely to have gains in their unstructured social participation after high school exit. Turning to relationships between internalizing and social activities, more internalizing symptoms while youth with ASD were in high school significantly predicted increasing social isolation after high school exit (both in terms of structured and unstructured activities). Results point to the likely need for additional supports during the transition to adulthood for youth with ASD who have internalizing problems. En ligne : http://dx.doi.org/10.1002/aur.1709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: A one-year follow-up / Hidetoshi TAKAHASHI in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.673-679 Titre : Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: A one-year follow-up Type de document : Texte imprimé et/ou numérique Auteurs : Hidetoshi TAKAHASHI, Auteur ; Takayuki NAKAHACHI, Auteur ; Andrew STICKLEY, Auteur ; Makoto ISHITOBI, Auteur ; Yoko KAMIO, Auteur Article en page(s) : p.673-679 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  acoustic startle response  prepulse inhibition  sensory-motor gating  habituation  startle latency  long-term stability  test–retest reliability Index. décimale : PER Périodiques Résumé : Auditory hyper-reactivity is a common sensory–perceptual abnormality that interrupts behavioral adaptations in autism spectrum disorders (ASD). Recently, prolonged acoustic startle response (ASR) latency and hyper-reactivity to weak acoustic stimuli were reported in children with ASD. Indexes of ASR and its modulation are known to be stable biological markers for translational research in the adult population. However, little is known about the stability of these indexes in children. Thus, the objective of our study was to investigate the stability of neurophysiological ASR indexes in children with ASD and typical development (TD). Participants included 12 children with ASD and 24 with TD. Mean startle magnitudes to acoustic stimuli presented at 65–105 dB in increments of 10 dB were analyzed. Average peak startle latency (PSL), ASR modulation of habituation, and prepulse inhibition were also analyzed. These startle measures were examined after a follow-up period of 15.7?±?5.1 months from baseline. At both baseline and in the follow-up period, children with ASD had significantly greater startle magnitudes to weak stimuli of 65–85 dB and more prolonged PSL compared with controls. Intraclass correlation coefficients for these ASR measures between both periods were 0.499–0.705. None of the ASR measures differed significantly between the two periods. Our results suggest that prolonged PSL and greater startle magnitudes to weak stimuli in children with ASD might serve as moderately stable neurophysiological indexes of ASD. En ligne : http://dx.doi.org/10.1002/aur.1710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: A one-year follow-up [Texte imprimé et/ou numérique] / Hidetoshi TAKAHASHI, Auteur ; Takayuki NAKAHACHI, Auteur ; Andrew STICKLEY, Auteur ; Makoto ISHITOBI, Auteur ; Yoko KAMIO, Auteur . - p.673-679. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.673-679 Mots-clés : autism spectrum disorders  acoustic startle response  prepulse inhibition  sensory-motor gating  habituation  startle latency  long-term stability  test–retest reliability Index. décimale : PER Périodiques Résumé : Auditory hyper-reactivity is a common sensory–perceptual abnormality that interrupts behavioral adaptations in autism spectrum disorders (ASD). Recently, prolonged acoustic startle response (ASR) latency and hyper-reactivity to weak acoustic stimuli were reported in children with ASD. Indexes of ASR and its modulation are known to be stable biological markers for translational research in the adult population. However, little is known about the stability of these indexes in children. Thus, the objective of our study was to investigate the stability of neurophysiological ASR indexes in children with ASD and typical development (TD). Participants included 12 children with ASD and 24 with TD. Mean startle magnitudes to acoustic stimuli presented at 65–105 dB in increments of 10 dB were analyzed. Average peak startle latency (PSL), ASR modulation of habituation, and prepulse inhibition were also analyzed. These startle measures were examined after a follow-up period of 15.7?±?5.1 months from baseline. At both baseline and in the follow-up period, children with ASD had significantly greater startle magnitudes to weak stimuli of 65–85 dB and more prolonged PSL compared with controls. Intraclass correlation coefficients for these ASR measures between both periods were 0.499–0.705. None of the ASR measures differed significantly between the two periods. Our results suggest that prolonged PSL and greater startle magnitudes to weak stimuli in children with ASD might serve as moderately stable neurophysiological indexes of ASD. En ligne : http://dx.doi.org/10.1002/aur.1710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Gender differences in autism spectrum disorders: Divergence among specific core symptoms / Anita BEGGIATO in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.680-689 Titre : Gender differences in autism spectrum disorders: Divergence among specific core symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Anita BEGGIATO, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Isabelle SCHEID, Auteur ; Maria RASTAM, Auteur ; Frédérique AMSELLEM, Auteur ; Carina I. GILLBERG, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Christopher GILLBERG, Auteur ; Richard DELORME, Auteur Article en page(s) : p.680-689 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  sex  gender  autism diagnosis interview-revised Index. décimale : PER Périodiques Résumé : Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P? En ligne : http://dx.doi.org/10.1002/aur.1715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Gender differences in autism spectrum disorders: Divergence among specific core symptoms [Texte imprimé et/ou numérique] / Anita BEGGIATO, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Isabelle SCHEID, Auteur ; Maria RASTAM, Auteur ; Frédérique AMSELLEM, Auteur ; Carina I. GILLBERG, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Christopher GILLBERG, Auteur ; Richard DELORME, Auteur . - p.680-689. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.680-689 Mots-clés : autism spectrum disorders  sex  gender  autism diagnosis interview-revised Index. décimale : PER Périodiques Résumé : Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P? En ligne : http://dx.doi.org/10.1002/aur.1715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Scientific Summaries for Families with ASD in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.690-694 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.690-694 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.690-694. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.690-694 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

International Society for Autism Research News www.autism-insar.org in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.695-696 Titre : International Society for Autism Research News www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.695-696 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1805 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] International Society for Autism Research News www.autism-insar.org [Texte imprimé et/ou numérique] . - p.695-696. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.695-696 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1805 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307