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Auteur Q. XU |
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Alterations in plasma cytokine levels in chinese children with autism spectrum disorder / C. C. HU in Autism Research, 11-7 (July 2018)
[article]
Titre : Alterations in plasma cytokine levels in chinese children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. C. HU, Auteur ; X. XU, Auteur ; G. L. XIONG, Auteur ; Q. XU, Auteur ; B. R. ZHOU, Auteur ; C. Y. LI, Auteur ; Q. QIN, Auteur ; C. X. LIU, Auteur ; H. P. LI, Auteur ; Y. J. SUN, Auteur ; X. YU, Auteur Article en page(s) : p.989-999 Langues : Anglais (eng) Mots-clés : TGF-beta1 TNF-alpha cytokine eotaxin immune neuroinflammation Index. décimale : PER Périodiques Résumé : Genetic alterations, together with environmental risk factors during infancy and childhood, contribute significantly to the etiology of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental condition characterized by impairments in social interaction and restricted, repetitive behaviors. Mounting evidence points to a critical contribution of immunological risk factors to the development of ASD. By affecting multiple neurodevelopmental processes, immune system dysfunction could act as a point of convergence between genetics and environmental factors in ASD. Previous studies have shown altered cytokine levels in individuals with ASD, but research in Asian populations are limited. Here, we measured the plasma levels of 11 candidate cytokines in ASD and typically developing (TD) children. The cohort included 41 TD children and 87 children with ASD, aged 1-6 years. We found that as compared to the TD group, children with ASD had higher plasma levels of Eotaxin, TGF-beta1 and TNF-alpha. The increase in TGF-beta1 level was most significant in males, while the increase in Eotaxin was most significant in females. Eotaxin level negatively correlated with the social affect score (SA) in ADOS, while TNF-alpha level positively correlated with total development quotient (DQ), measured using GMDS. These pilot findings suggest potentially important roles of Eotaxin, TGF-beta1 and TNF-alpha in ASD in the Chinese population. Autism Res 2018, 11: 989-999. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Alteration of immune system function is an important risk factor for autism spectrum disorder (ASD). Here we found that the levels of cytokines, including Eotaxin, TGF-beta1 and TNF-alpha, are elevated in Chinese children with ASD, as compared to typically developing children. The change in TGF-beta1 level was most prominent in boys, while that of Eotaxin was more significant in girls. These results provide evidence for changes in cytokine profile in Chinese children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Autism Research > 11-7 (July 2018) . - p.989-999[article] Alterations in plasma cytokine levels in chinese children with autism spectrum disorder [Texte imprimé et/ou numérique] / C. C. HU, Auteur ; X. XU, Auteur ; G. L. XIONG, Auteur ; Q. XU, Auteur ; B. R. ZHOU, Auteur ; C. Y. LI, Auteur ; Q. QIN, Auteur ; C. X. LIU, Auteur ; H. P. LI, Auteur ; Y. J. SUN, Auteur ; X. YU, Auteur . - p.989-999.
Langues : Anglais (eng)
in Autism Research > 11-7 (July 2018) . - p.989-999
Mots-clés : TGF-beta1 TNF-alpha cytokine eotaxin immune neuroinflammation Index. décimale : PER Périodiques Résumé : Genetic alterations, together with environmental risk factors during infancy and childhood, contribute significantly to the etiology of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental condition characterized by impairments in social interaction and restricted, repetitive behaviors. Mounting evidence points to a critical contribution of immunological risk factors to the development of ASD. By affecting multiple neurodevelopmental processes, immune system dysfunction could act as a point of convergence between genetics and environmental factors in ASD. Previous studies have shown altered cytokine levels in individuals with ASD, but research in Asian populations are limited. Here, we measured the plasma levels of 11 candidate cytokines in ASD and typically developing (TD) children. The cohort included 41 TD children and 87 children with ASD, aged 1-6 years. We found that as compared to the TD group, children with ASD had higher plasma levels of Eotaxin, TGF-beta1 and TNF-alpha. The increase in TGF-beta1 level was most significant in males, while the increase in Eotaxin was most significant in females. Eotaxin level negatively correlated with the social affect score (SA) in ADOS, while TNF-alpha level positively correlated with total development quotient (DQ), measured using GMDS. These pilot findings suggest potentially important roles of Eotaxin, TGF-beta1 and TNF-alpha in ASD in the Chinese population. Autism Res 2018, 11: 989-999. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Alteration of immune system function is an important risk factor for autism spectrum disorder (ASD). Here we found that the levels of cytokines, including Eotaxin, TGF-beta1 and TNF-alpha, are elevated in Chinese children with ASD, as compared to typically developing children. The change in TGF-beta1 level was most prominent in boys, while that of Eotaxin was more significant in girls. These results provide evidence for changes in cytokine profile in Chinese children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons / Q. XU in Molecular Autism, 9 (2018)
[article]
Titre : Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons Type de document : Texte imprimé et/ou numérique Auteurs : Q. XU, Auteur ; Y. Y. LIU, Auteur ; X. WANG, Auteur ; G. H. TAN, Auteur ; H. P. LI, Auteur ; S. W. HULBERT, Auteur ; C. Y. LI, Auteur ; C. C. HU, Auteur ; Z. Q. XIONG, Auteur ; X. XU, Auteur ; Y. H. JIANG, Auteur Article en page(s) : 65 p. Langues : Anglais (eng) Mots-clés : Animals Autistic Disorder/*genetics/pathology Cells, Cultured Cerebral Cortex/cytology/growth & development DNA-Binding Proteins/*genetics/metabolism Humans Mice Mice, Inbred C57BL *Neurogenesis Neurons/cytology/*metabolism/physiology *Autism spectrum disorder (ASD) *chd8 *Chromatin remodeling *Neurite growth *Neurodevelopment Animal Care and Use Committee-approved protocols both at Children's Hospital of Fudan University ethics approval ID: 2015-87 and Duke University. Human postmortem brain tissues: The use of archived human postmortem brain tissues is approved by Institute Review Board at Duke University.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruiting histone H1 to target genes. The mechanism by which deficiency of CHD8 causes ASD has not been fully elucidated. Methods: We examined the expression of CHD8 in human and mouse brains using both immunohistochemistry and RNA in situ hybridization. We performed in utero electroporation, neuronal culture, and biochemical analysis using RNAi to examine the functional consequences of CHD8 deficiency. Results: We discovered that CHD8 is expressed highly in neurons and at low levels in glia cells in both humans and mice. Specifically, CHD8 is localized predominately in the nucleus of both MAP2 and parvalbumin-positive neurons. In the developing mouse brain, expression of Chd8 peaks from E16 to E18 and then decreases significantly at P14 to adulthood. Knockdown of Chd8 results in reduced axon and dendritic growth, disruption of axon projections to the contralateral cortex, and delayed neuronal migration at E18.5 which recovers by P3 and P7. Conclusion: Our findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. En ligne : https://dx.doi.org/10.1186/s13229-018-0244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 9 (2018) . - 65 p.[article] Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons [Texte imprimé et/ou numérique] / Q. XU, Auteur ; Y. Y. LIU, Auteur ; X. WANG, Auteur ; G. H. TAN, Auteur ; H. P. LI, Auteur ; S. W. HULBERT, Auteur ; C. Y. LI, Auteur ; C. C. HU, Auteur ; Z. Q. XIONG, Auteur ; X. XU, Auteur ; Y. H. JIANG, Auteur . - 65 p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 65 p.
Mots-clés : Animals Autistic Disorder/*genetics/pathology Cells, Cultured Cerebral Cortex/cytology/growth & development DNA-Binding Proteins/*genetics/metabolism Humans Mice Mice, Inbred C57BL *Neurogenesis Neurons/cytology/*metabolism/physiology *Autism spectrum disorder (ASD) *chd8 *Chromatin remodeling *Neurite growth *Neurodevelopment Animal Care and Use Committee-approved protocols both at Children's Hospital of Fudan University ethics approval ID: 2015-87 and Duke University. Human postmortem brain tissues: The use of archived human postmortem brain tissues is approved by Institute Review Board at Duke University.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruiting histone H1 to target genes. The mechanism by which deficiency of CHD8 causes ASD has not been fully elucidated. Methods: We examined the expression of CHD8 in human and mouse brains using both immunohistochemistry and RNA in situ hybridization. We performed in utero electroporation, neuronal culture, and biochemical analysis using RNAi to examine the functional consequences of CHD8 deficiency. Results: We discovered that CHD8 is expressed highly in neurons and at low levels in glia cells in both humans and mice. Specifically, CHD8 is localized predominately in the nucleus of both MAP2 and parvalbumin-positive neurons. In the developing mouse brain, expression of Chd8 peaks from E16 to E18 and then decreases significantly at P14 to adulthood. Knockdown of Chd8 results in reduced axon and dendritic growth, disruption of axon projections to the contralateral cortex, and delayed neuronal migration at E18.5 which recovers by P3 and P7. Conclusion: Our findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. En ligne : https://dx.doi.org/10.1186/s13229-018-0244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Effects of Parent-Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non-Randomized Controlled Trial / B. ZHOU in Autism Research, 11-4 (April 2018)
[article]
Titre : Effects of Parent-Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non-Randomized Controlled Trial Type de document : Texte imprimé et/ou numérique Auteurs : B. ZHOU, Auteur ; Q. XU, Auteur ; H. LI, Auteur ; Y. ZHANG, Auteur ; Y. WANG, Auteur ; Sally J ROGERS, Auteur ; X. XU, Auteur Article en page(s) : p.654-666 Langues : Anglais (eng) Mots-clés : Parent-implemented Early Start Denver Model (P-ESDM) autism spectrum disorder early intervention parenting stress toddler Index. décimale : PER Périodiques Résumé : To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age-matched toddlers with ASD (n = 20) was recruited from other areas. Subjects of the P-ESDM group attended 1.5-hr parent coaching per week for 26 weeks, and those in the community group received interventions available from communities. Assessments were conducted at baseline (T1) and 26 weeks later (T2). After adjusting for baseline differences between the two groups, P-ESDM group demonstrated greater improvement than the community group in general development, especially in Language domain. Neither group demonstrated significant change in ASD severity, but the P-ESDM group showed greater improvement in social affect, parent-reported social communication and symbolic play than community group did. Finally, parents in P-ESDM group experienced decreased parenting stress while those in community group showed an opposite trend, though the differences did not reach significant association with the P-ESDM intervention. Chinese toddlers with ASD receiving 26 weeks of P-ESDM via regular coaching sessions showed significant greater improvement than those receiving community interventions in multiple aspects of development including social communications. These findings add support to the importance of providing early screening, diagnosis, and immediate referral for evidence-based interventions to improve outcome of young children with ASD. Autism Res 2018, 11: 654-666. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The development of early screening and diagnosis of autism spectrum disorder (ASD) in China has highlighted the importance of early intervention for young children with ASD. Our current study demonstrated that parent-implemented Early Start Denver Model (P-ESDM) via coaching from professionals improved developmental outcomes, especially in the language domain, and social communicational behaviors of Chinese toddlers with ASD. P-ESDM may help parents in China provide effective early intervention to their children with ASD via improving their skills when they are still at a waiting list for services or lack access to intervention, and has the potential to alleviate their parenting stress. En ligne : http://dx.doi.org/10.1002/aur.1917 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358
in Autism Research > 11-4 (April 2018) . - p.654-666[article] Effects of Parent-Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non-Randomized Controlled Trial [Texte imprimé et/ou numérique] / B. ZHOU, Auteur ; Q. XU, Auteur ; H. LI, Auteur ; Y. ZHANG, Auteur ; Y. WANG, Auteur ; Sally J ROGERS, Auteur ; X. XU, Auteur . - p.654-666.
Langues : Anglais (eng)
in Autism Research > 11-4 (April 2018) . - p.654-666
Mots-clés : Parent-implemented Early Start Denver Model (P-ESDM) autism spectrum disorder early intervention parenting stress toddler Index. décimale : PER Périodiques Résumé : To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age-matched toddlers with ASD (n = 20) was recruited from other areas. Subjects of the P-ESDM group attended 1.5-hr parent coaching per week for 26 weeks, and those in the community group received interventions available from communities. Assessments were conducted at baseline (T1) and 26 weeks later (T2). After adjusting for baseline differences between the two groups, P-ESDM group demonstrated greater improvement than the community group in general development, especially in Language domain. Neither group demonstrated significant change in ASD severity, but the P-ESDM group showed greater improvement in social affect, parent-reported social communication and symbolic play than community group did. Finally, parents in P-ESDM group experienced decreased parenting stress while those in community group showed an opposite trend, though the differences did not reach significant association with the P-ESDM intervention. Chinese toddlers with ASD receiving 26 weeks of P-ESDM via regular coaching sessions showed significant greater improvement than those receiving community interventions in multiple aspects of development including social communications. These findings add support to the importance of providing early screening, diagnosis, and immediate referral for evidence-based interventions to improve outcome of young children with ASD. Autism Res 2018, 11: 654-666. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The development of early screening and diagnosis of autism spectrum disorder (ASD) in China has highlighted the importance of early intervention for young children with ASD. Our current study demonstrated that parent-implemented Early Start Denver Model (P-ESDM) via coaching from professionals improved developmental outcomes, especially in the language domain, and social communicational behaviors of Chinese toddlers with ASD. P-ESDM may help parents in China provide effective early intervention to their children with ASD via improving their skills when they are still at a waiting list for services or lack access to intervention, and has the potential to alleviate their parenting stress. En ligne : http://dx.doi.org/10.1002/aur.1917 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai / C. LI in Autism Research, 11-9 (September 2018)
[article]
Titre : Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai Type de document : Texte imprimé et/ou numérique Auteurs : C. LI, Auteur ; G. ZHU, Auteur ; J. FENG, Auteur ; Q. XU, Auteur ; Z. ZHOU, Auteur ; B. ZHOU, Auteur ; C. HU, Auteur ; C. LIU, Auteur ; H. LI, Auteur ; Y. WANG, Auteur ; W. YAN, Auteur ; X. GE, Auteur ; X. XU, Auteur Article en page(s) : p.1206-1217 Langues : Anglais (eng) Mots-clés : Chat-23 China autism spectrum disorder community-based early screening Index. décimale : PER Périodiques Résumé : Most children with autism spectrum disorder (ASD) are not diagnosed until the age of 4, thus missing the opportunity for early intervention. The objective of this study was to investigate the feasibility of an early screening program for ASD applied during well-child visits in a community-based sample. The study lasted for 4 years and was divided into two stages. Stage I involved the implementation of the basic screening model in 2014. Toddlers received level 1 screening via section A of the Chinese-validated version of the Checklist for Autism in Toddlers (CHAT-23) during 18- and 24-month well-child visits in Xuhui District, Shanghai, China. Screen-positive children were referred to receive section B of the CHAT-23 for level 2 screening, and those still screen-positive were referred to undergo diagnosis and evaluation. Stage II involved the implementation of the improved screening model from 2015 to 2017 with the following modifications: (a) an added observational component in level 1 screening; (b) telephone follow-ups with the screen-positive families; and (c) dissemination of information on ASD to families. The results showed that 42 of 22,247 screened children were diagnosed with ASD. The ASD diagnosis rates were 0.1% in Stage I and 0.21% in Stage II. The screen-positive rate and the show rate of referral for level 1 screening increased by 76.92% and 58.43%, respectively, in Stage II compared to Stage I. Our results suggest that with appropriate logistic support, this two-level screening model is feasible and effective for the early screening of ASD during well-child visits. Autism Res 2018, 11: 1206-1217. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Difficulty in the timely identification of autism spectrum disorder (ASD) results in missed opportunities for many ASD children to receive early intervention. In this study, we established an early screening model for ASD among children aged 18-24 months in the community by relying on the three-level child healthcare system in China. The results showed that this model can effectively identify and diagnose ASD in children at an early age and thus enable early intervention. En ligne : http://dx.doi.org/10.1002/aur.1984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-9 (September 2018) . - p.1206-1217[article] Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai [Texte imprimé et/ou numérique] / C. LI, Auteur ; G. ZHU, Auteur ; J. FENG, Auteur ; Q. XU, Auteur ; Z. ZHOU, Auteur ; B. ZHOU, Auteur ; C. HU, Auteur ; C. LIU, Auteur ; H. LI, Auteur ; Y. WANG, Auteur ; W. YAN, Auteur ; X. GE, Auteur ; X. XU, Auteur . - p.1206-1217.
Langues : Anglais (eng)
in Autism Research > 11-9 (September 2018) . - p.1206-1217
Mots-clés : Chat-23 China autism spectrum disorder community-based early screening Index. décimale : PER Périodiques Résumé : Most children with autism spectrum disorder (ASD) are not diagnosed until the age of 4, thus missing the opportunity for early intervention. The objective of this study was to investigate the feasibility of an early screening program for ASD applied during well-child visits in a community-based sample. The study lasted for 4 years and was divided into two stages. Stage I involved the implementation of the basic screening model in 2014. Toddlers received level 1 screening via section A of the Chinese-validated version of the Checklist for Autism in Toddlers (CHAT-23) during 18- and 24-month well-child visits in Xuhui District, Shanghai, China. Screen-positive children were referred to receive section B of the CHAT-23 for level 2 screening, and those still screen-positive were referred to undergo diagnosis and evaluation. Stage II involved the implementation of the improved screening model from 2015 to 2017 with the following modifications: (a) an added observational component in level 1 screening; (b) telephone follow-ups with the screen-positive families; and (c) dissemination of information on ASD to families. The results showed that 42 of 22,247 screened children were diagnosed with ASD. The ASD diagnosis rates were 0.1% in Stage I and 0.21% in Stage II. The screen-positive rate and the show rate of referral for level 1 screening increased by 76.92% and 58.43%, respectively, in Stage II compared to Stage I. Our results suggest that with appropriate logistic support, this two-level screening model is feasible and effective for the early screening of ASD during well-child visits. Autism Res 2018, 11: 1206-1217. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Difficulty in the timely identification of autism spectrum disorder (ASD) results in missed opportunities for many ASD children to receive early intervention. In this study, we established an early screening model for ASD among children aged 18-24 months in the community by relying on the three-level child healthcare system in China. The results showed that this model can effectively identify and diagnose ASD in children at an early age and thus enable early intervention. En ligne : http://dx.doi.org/10.1002/aur.1984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369