Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples / Russell SCHACHAR in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.881-889 Titre : Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples Type de document : Texte imprimé et/ou numérique Auteurs : Russell SCHACHAR, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Noam SORENI, Auteur ; Paul D. ARNOLD, Auteur ; Christie L. BURTON, Auteur ; Jennifer CROSBIE, Auteur Article en page(s) : p.881-889 Langues : Anglais (eng) Mots-clés : Adolescent  Attention  Child  Comorbidity  Humans  Obsessive-Compulsive Disorder/diagnosis  Phenotype  Reaction Time/physiology  Ocd  Stop-signal task  executive function  neurocognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurocognitive impairments are common in OCD, although not well studied in children and youth with the disorder. METHOD: Using the stop-signal task (SST), we measured response inhibition (stop-signal reaction time-SSRT), sustained attention (reaction time variability-RTV), reaction time (RT), and performance monitoring (post-error slowing-PES) in OCD cases and controls from two samples of children and youth. A Clinic OCD group (n=171, aged 7-17years) was recruited from a specialty clinic after rigorous assessment. A typically developing (Clinic TD, n=157) group was enlisted through advertisement. A community OCD sample (Community OCD, n=147) and controls (Community TD n=13,832, aged 6-17 years) were recruited at a science museum. We also identified a community group with high OCD traits without an OCD diagnosis (Community High Trait; n=125). RESULTS: Clinic OCD participants had longer SSRT and greater RTV than Clinic TD. These effects were greater in younger OCD participants and, for SSRT, in those on medication for OCD. The Community OCD group did not differ from Controls but was similar to the Clinic OCD group in ADHD and ASD comorbidity and medication usage. The Community High Trait group had longer SSRT and atypical PES suggesting that symptom severity predicts neurocognitive function. No group differences were found in RT. CONCLUSIONS: In the largest study of neurocognitive performance in children with OCD to date, we found impaired response inhibition and sustained attention in OCD participants in comparison to typically developing peers. Performance was worse in younger OCD participants. In the community sample, participants with high OCD trait scores but no OCD diagnosis had impaired response inhibition and error processing, suggesting that OCD might be under-recognized. En ligne : http://dx.doi.org/10.1111/jcpp.13533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples [Texte imprimé et/ou numérique] / Russell SCHACHAR, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Noam SORENI, Auteur ; Paul D. ARNOLD, Auteur ; Christie L. BURTON, Auteur ; Jennifer CROSBIE, Auteur . - p.881-889. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.881-889 Mots-clés : Adolescent  Attention  Child  Comorbidity  Humans  Obsessive-Compulsive Disorder/diagnosis  Phenotype  Reaction Time/physiology  Ocd  Stop-signal task  executive function  neurocognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurocognitive impairments are common in OCD, although not well studied in children and youth with the disorder. METHOD: Using the stop-signal task (SST), we measured response inhibition (stop-signal reaction time-SSRT), sustained attention (reaction time variability-RTV), reaction time (RT), and performance monitoring (post-error slowing-PES) in OCD cases and controls from two samples of children and youth. A Clinic OCD group (n=171, aged 7-17years) was recruited from a specialty clinic after rigorous assessment. A typically developing (Clinic TD, n=157) group was enlisted through advertisement. A community OCD sample (Community OCD, n=147) and controls (Community TD n=13,832, aged 6-17 years) were recruited at a science museum. We also identified a community group with high OCD traits without an OCD diagnosis (Community High Trait; n=125). RESULTS: Clinic OCD participants had longer SSRT and greater RTV than Clinic TD. These effects were greater in younger OCD participants and, for SSRT, in those on medication for OCD. The Community OCD group did not differ from Controls but was similar to the Clinic OCD group in ADHD and ASD comorbidity and medication usage. The Community High Trait group had longer SSRT and atypical PES suggesting that symptom severity predicts neurocognitive function. No group differences were found in RT. CONCLUSIONS: In the largest study of neurocognitive performance in children with OCD to date, we found impaired response inhibition and sustained attention in OCD participants in comparison to typically developing peers. Performance was worse in younger OCD participants. In the community sample, participants with high OCD trait scores but no OCD diagnosis had impaired response inhibition and error processing, suggesting that OCD might be under-recognized. En ligne : http://dx.doi.org/10.1111/jcpp.13533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

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