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Auteur Kurt E. WEAVER |
Documents disponibles écrits par cet auteur (1)
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Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 39-7 (July 2009)
[article]
Titre : Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Natalia M. KLEINHANS, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur ; Todd RICHARDS, Auteur ; Kurt E. WEAVER, Auteur ; Olivia LIANG, Auteur Année de publication : 2009 Article en page(s) : p.1079-1086 Langues : Anglais (eng) Mots-clés : Amygdala Autism Asperger’s-disorder MRS Index. décimale : PER Périodiques Résumé : Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0707-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770
in Journal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1079-1086[article] Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder [Texte imprimé et/ou numérique] / Natalia M. KLEINHANS, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur ; Todd RICHARDS, Auteur ; Kurt E. WEAVER, Auteur ; Olivia LIANG, Auteur . - 2009 . - p.1079-1086.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1079-1086
Mots-clés : Amygdala Autism Asperger’s-disorder MRS Index. décimale : PER Périodiques Résumé : Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0707-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770