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Auteur Brian R. PIKE |
Documents disponibles écrits par cet auteur (1)
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Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 / Robert J. HAMM in Cognitive Brain Research, 1-4 (December 1993)
[article]
Titre : Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 Type de document : Texte imprimé et/ou numérique Auteurs : Robert J. HAMM, Auteur ; Dianne M. O'DELL, Auteur ; Brian R. PIKE, Auteur ; Bruce G. LYETH, Auteur Année de publication : 1993 Article en page(s) : p.223-226 Langues : Anglais (eng) Mots-clés : Traumatic-brain-injury Morris-water-maze Scopolamine;MK-801 Rat Index. décimale : PER Périodiques Résumé : In order to examine the effectiveness of pre- and post-injury administration of muscarinic cholinergic and NMDA antagonists in reducing cognitive deficits following traumatic brain injury (TBI), rats were injected with either scopolamine (1 mg/kg) or MK-801 (0.3 mg/kg) 15 min prior to or 15 min after fluid percussion TBI. Cognitive performance was assessed with the Morris water maze procedure on days 11–15 after TBI or sham injury. When scopolamine and MK-801 were injected 15 min before injury, Morris water maze deficits were significantly reduced (P < 0.01 and P < 0.05, respectively). When scopolamine and MK-801 were injected 15 min after TBI, neither drug was effective in attenuating Morris water maze deficits. Consistent with other research, these results suggest that the cognitive deficits produced by TBI are the consequence of a brief period of excessive excitation of cholinergic and NMDA receptor systems. The results of this experiment also suggest that the temporal therapeutic window for the treatment of cognitive dysfunction with receptor antagonist intervention appears to be quite brief ( < 15 min) in the rat. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782
in Cognitive Brain Research > 1-4 (December 1993) . - p.223-226[article] Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 [Texte imprimé et/ou numérique] / Robert J. HAMM, Auteur ; Dianne M. O'DELL, Auteur ; Brian R. PIKE, Auteur ; Bruce G. LYETH, Auteur . - 1993 . - p.223-226.
Langues : Anglais (eng)
in Cognitive Brain Research > 1-4 (December 1993) . - p.223-226
Mots-clés : Traumatic-brain-injury Morris-water-maze Scopolamine;MK-801 Rat Index. décimale : PER Périodiques Résumé : In order to examine the effectiveness of pre- and post-injury administration of muscarinic cholinergic and NMDA antagonists in reducing cognitive deficits following traumatic brain injury (TBI), rats were injected with either scopolamine (1 mg/kg) or MK-801 (0.3 mg/kg) 15 min prior to or 15 min after fluid percussion TBI. Cognitive performance was assessed with the Morris water maze procedure on days 11–15 after TBI or sham injury. When scopolamine and MK-801 were injected 15 min before injury, Morris water maze deficits were significantly reduced (P < 0.01 and P < 0.05, respectively). When scopolamine and MK-801 were injected 15 min after TBI, neither drug was effective in attenuating Morris water maze deficits. Consistent with other research, these results suggest that the cognitive deficits produced by TBI are the consequence of a brief period of excessive excitation of cholinergic and NMDA receptor systems. The results of this experiment also suggest that the temporal therapeutic window for the treatment of cognitive dysfunction with receptor antagonist intervention appears to be quite brief ( < 15 min) in the rat. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782