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Auteur Joseph D. BUXBAUM |
Documents disponibles écrits par cet auteur (67)
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Reduced engagement of visual attention in children with autism spectrum disorder / C. S. MCLAUGHLIN in Autism, 25-7 (October 2021)
[article]
Titre : Reduced engagement of visual attention in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. S. MCLAUGHLIN, Auteur ; H. E. GROSMAN, Auteur ; S. B. GUILLORY, Auteur ; E. L. ISENSTEIN, Auteur ; E. WILKINSON, Auteur ; M. D. P. TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; P. M. SIPER, Auteur ; A. KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; J. H. FOSS-FEIG, Auteur Article en page(s) : p.2064-2073 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Humans Nonverbal Communication autism spectrum disorders eye-tracking gap effect saccade social visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-7 (October 2021) . - p.2064-2073[article] Reduced engagement of visual attention in children with autism spectrum disorder [Texte imprimé et/ou numérique] / C. S. MCLAUGHLIN, Auteur ; H. E. GROSMAN, Auteur ; S. B. GUILLORY, Auteur ; E. L. ISENSTEIN, Auteur ; E. WILKINSON, Auteur ; M. D. P. TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; P. M. SIPER, Auteur ; A. KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; J. H. FOSS-FEIG, Auteur . - p.2064-2073.
Langues : Anglais (eng)
in Autism > 25-7 (October 2021) . - p.2064-2073
Mots-clés : Autism Spectrum Disorder Child Humans Nonverbal Communication autism spectrum disorders eye-tracking gap effect saccade social visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 Reduced engagement of visual attention in children with autism spectrum disorder / Christopher S. MCLAUGHLIN in Autism, 26-7 (October 2022)
[article]
Titre : Reduced engagement of visual attention in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2064-2073 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Humans Nonverbal Communication autism spectrum disorders eye-tracking gap effect saccade social visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Autism > 26-7 (October 2022) . - p.2064-2073[article] Reduced engagement of visual attention in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2064-2073.
Langues : Anglais (eng)
in Autism > 26-7 (October 2022) . - p.2064-2073
Mots-clés : Autism Spectrum Disorder Child Humans Nonverbal Communication autism spectrum disorders eye-tracking gap effect saccade social visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 Rigor in science and science reporting: updated guidelines for submissions to Molecular Autism / Joseph D. BUXBAUM in Molecular Autism, 10 (2019)
[article]
Titre : Rigor in science and science reporting: updated guidelines for submissions to Molecular Autism Type de document : Texte imprimé et/ou numérique Auteurs : Joseph D. BUXBAUM, Auteur ; Simon BARON-COHEN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Chris ASHWIN, Auteur ; Catalina BETANCUR, Auteur ; Bhismadev CHAKRABARTI, Auteur ; J. N. CRAWLEY, Auteur ; R. A. HOEKSTRA, Auteur ; P. R. HOF, Auteur ; Meng-Chuan LAI, Auteur ; M. V. LOMBARDO, Auteur ; C. M. SCHUMANN, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1186/s13229-018-0249-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 10 (2019) . - 6 p.[article] Rigor in science and science reporting: updated guidelines for submissions to Molecular Autism [Texte imprimé et/ou numérique] / Joseph D. BUXBAUM, Auteur ; Simon BARON-COHEN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Chris ASHWIN, Auteur ; Catalina BETANCUR, Auteur ; Bhismadev CHAKRABARTI, Auteur ; J. N. CRAWLEY, Auteur ; R. A. HOEKSTRA, Auteur ; P. R. HOF, Auteur ; Meng-Chuan LAI, Auteur ; M. V. LOMBARDO, Auteur ; C. M. SCHUMANN, Auteur . - 6 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 6 p.
Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1186/s13229-018-0249-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 SHANK2 and SHANK3 Mutations Implicate Glutamate Signaling Abnormalities in Autism Spectrum Disorders / Hala HARONY-NICOLAS
Titre : SHANK2 and SHANK3 Mutations Implicate Glutamate Signaling Abnormalities in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hala HARONY-NICOLAS, Auteur ; Ozlem Bozdagi GUNAL, Auteur ; Joseph D. BUXBAUM, Auteur Année de publication : 2013 Importance : p.437-448 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The SHANK family of genes encodes proteins (Shank1, 2, 3) that are core components of the postsynaptic density. Shank proteins contain multiple domains involved in protein-protein interactions, which link glutamate receptors to the actin cytoskeleton. Recent genetic and functional data implicate mutations in the human Shank2 and Shank3 genes in autism spectrum disorders (ASD). Several genetic mutations and rare copy number variants in these genes have been identified in ASD patients, with SHANK3 disruption now being one of the most common monogenic forms of ASD. Given that Shank and Shank promote the formation, maturation, and enlargement of dendritic spines, supporting the role of synaptic pathology in ASD, it becomes important to make use of animal (typically mouse and rat) models lacking Shanks, to study the underlying synaptic and neuronal pathophysiology of ASD. To this end, different Shank3 rodent models have been generated in an effort to explain the role of SHANK3 mutations in ASD, with the aim of identifying potential therapeutic targets for ASD that can also be tested in these animal models. In the current chapter we summarize in vitro and in vivo studies on Shank proteins, and relate these findings to the dysregulation of glutamate signaling in ASD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 SHANK2 and SHANK3 Mutations Implicate Glutamate Signaling Abnormalities in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Hala HARONY-NICOLAS, Auteur ; Ozlem Bozdagi GUNAL, Auteur ; Joseph D. BUXBAUM, Auteur . - 2013 . - p.437-448.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The SHANK family of genes encodes proteins (Shank1, 2, 3) that are core components of the postsynaptic density. Shank proteins contain multiple domains involved in protein-protein interactions, which link glutamate receptors to the actin cytoskeleton. Recent genetic and functional data implicate mutations in the human Shank2 and Shank3 genes in autism spectrum disorders (ASD). Several genetic mutations and rare copy number variants in these genes have been identified in ASD patients, with SHANK3 disruption now being one of the most common monogenic forms of ASD. Given that Shank and Shank promote the formation, maturation, and enlargement of dendritic spines, supporting the role of synaptic pathology in ASD, it becomes important to make use of animal (typically mouse and rat) models lacking Shanks, to study the underlying synaptic and neuronal pathophysiology of ASD. To this end, different Shank3 rodent models have been generated in an effort to explain the role of SHANK3 mutations in ASD, with the aim of identifying potential therapeutic targets for ASD that can also be tested in these animal models. In the current chapter we summarize in vitro and in vivo studies on Shank proteins, and relate these findings to the dysregulation of glutamate signaling in ASD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Shank3?deficient rats exhibit degraded cortical responses to sound / T. ENGINEER CRYSTAL in Autism Research, 11-1 (January 2018)
[article]
Titre : Shank3?deficient rats exhibit degraded cortical responses to sound Type de document : Texte imprimé et/ou numérique Auteurs : T. ENGINEER CRYSTAL, Auteur ; C. RAHEBI KIMIYA, Auteur ; S. BORLAND MICHAEL, Auteur ; P. BUELL ELIZABETH, Auteur ; W. IM KWOK, Auteur ; Linda G. WILSON, Auteur ; Pryanka SHARMA, Auteur ; Sven VANNESTE, Auteur ; Hala HARONY-NICOLAS, Auteur ; Joseph D. BUXBAUM, Auteur ; P. KILGARD MICHAEL, Auteur Article en page(s) : p.59-68 Langues : Anglais (eng) Mots-clés : Phelan?McDermid syndrome 22q13 deletion autism SHANK3?haploinsufficiency syndromes Index. décimale : PER Périodiques Résumé : Individuals with SHANK3 mutations have severely impaired receptive and expressive language abilities. While brain responses are known to be abnormal in these individuals, the auditory cortex response to sound has remained largely understudied. In this study, we document the auditory cortex response to speech and non?speech sounds in the novel Shank3?deficient rat model. We predicted that the auditory cortex response to sounds would be impaired in Shank3?deficient rats. We found that auditory cortex responses were weaker in Shank3 heterozygous rats compared to wild?type rats. Additionally, Shank3 heterozygous responses had less spontaneous auditory cortex firing and were unable to respond well to rapid trains of noise bursts. The rat model of the auditory impairments in SHANK3 mutation could be used to test potential rehabilitation or drug therapies to improve the communication impairments observed in individuals with Phelan?McDermid syndrome. Autism Res 2018, 11: 59?68. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Individuals with SHANK3 mutations have severely impaired language abilities, yet the auditory cortex response to sound has remained largely understudied. In this study, we found that auditory cortex responses were weaker and were unable to respond well to rapid sounds in Shank3?deficient rats compared to control rats. The rat model of the auditory impairments in SHANK3 mutation could be used to test potential rehabilitation or drug therapies to improve the communication impairments observed in individuals with Phelan?McDermid syndrome. En ligne : https://doi.org/10.1002/aur.1883 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333
in Autism Research > 11-1 (January 2018) . - p.59-68[article] Shank3?deficient rats exhibit degraded cortical responses to sound [Texte imprimé et/ou numérique] / T. ENGINEER CRYSTAL, Auteur ; C. RAHEBI KIMIYA, Auteur ; S. BORLAND MICHAEL, Auteur ; P. BUELL ELIZABETH, Auteur ; W. IM KWOK, Auteur ; Linda G. WILSON, Auteur ; Pryanka SHARMA, Auteur ; Sven VANNESTE, Auteur ; Hala HARONY-NICOLAS, Auteur ; Joseph D. BUXBAUM, Auteur ; P. KILGARD MICHAEL, Auteur . - p.59-68.
Langues : Anglais (eng)
in Autism Research > 11-1 (January 2018) . - p.59-68
Mots-clés : Phelan?McDermid syndrome 22q13 deletion autism SHANK3?haploinsufficiency syndromes Index. décimale : PER Périodiques Résumé : Individuals with SHANK3 mutations have severely impaired receptive and expressive language abilities. While brain responses are known to be abnormal in these individuals, the auditory cortex response to sound has remained largely understudied. In this study, we document the auditory cortex response to speech and non?speech sounds in the novel Shank3?deficient rat model. We predicted that the auditory cortex response to sounds would be impaired in Shank3?deficient rats. We found that auditory cortex responses were weaker in Shank3 heterozygous rats compared to wild?type rats. Additionally, Shank3 heterozygous responses had less spontaneous auditory cortex firing and were unable to respond well to rapid trains of noise bursts. The rat model of the auditory impairments in SHANK3 mutation could be used to test potential rehabilitation or drug therapies to improve the communication impairments observed in individuals with Phelan?McDermid syndrome. Autism Res 2018, 11: 59?68. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Individuals with SHANK3 mutations have severely impaired language abilities, yet the auditory cortex response to sound has remained largely understudied. In this study, we found that auditory cortex responses were weaker and were unable to respond well to rapid sounds in Shank3?deficient rats compared to control rats. The rat model of the auditory impairments in SHANK3 mutation could be used to test potential rehabilitation or drug therapies to improve the communication impairments observed in individuals with Phelan?McDermid syndrome. En ligne : https://doi.org/10.1002/aur.1883 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 SHANK3 haploinsufficiency: a common but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders / Catalina BETANCUR in Molecular Autism, (June 2013)
PermalinkShifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome / M. G. MARISCAL in Molecular Autism, 12 (2021)
PermalinkA Simplified Diagnostic Observational Assessment of Autism Spectrum Disorder in Early Childhood / David GRODBERG in Autism Research, 9-4 (April 2016)
PermalinkThe Autism Mental Status Exam: Sensitivity and Specificity Using DSM-5 Criteria for Autism Spectrum Disorder in Verbally Fluent Adults / David GRODBERG in Journal of Autism and Developmental Disorders, 44-3 (March 2014)
PermalinkThe Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses / Joseph D. BUXBAUM in Molecular Autism, (May 2014)
PermalinkThe Effect of an Autism-Associated Polymorphism in the STK39 Gene on the Autism Symptom Domains / Rick D. VAVOLIZZA in Journal of Autism and Developmental Disorders, 42-2 (February 2012)
PermalinkThe Immersive Theater Experience for Individuals with Autism Spectrum Disorder / Ivy GISERMAN-KISS in Journal of Autism and Developmental Disorders, 50-3 (March 2020)
PermalinkThe Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM
PermalinkTranscriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism / Michael S. BREEN in Molecular Autism, 11 (2020)
PermalinkTranscriptomic changes in the frontal cortex associated with paternal age / Rebecca G. SMITH in Molecular Autism, (March 2014)
PermalinkUltrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice / Neha UPPAL in Molecular Autism, (June 2015)
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