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Auteur Bart BOETS |
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Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study / Bart BOETS in Molecular Autism, 9 (2018)
[article]
Titre : Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study Type de document : Texte imprimé et/ou numérique Auteurs : Bart BOETS, Auteur ; L. VAN EYLEN, Auteur ; K. SITEK, Auteur ; P. MOORS, Auteur ; I. NOENS, Auteur ; J. STEYAERT, Auteur ; S. SUNAERT, Auteur ; J. WAGEMANS, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Diffusion-weighted imaging Inferior longitudinal fasciculus Structural connectivity Visual processing Index. décimale : PER Périodiques Résumé : Background: One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF). This study aimed at replicating the observation of reduced FA along the right ILF in ASD, while controlling for group differences in head motion and data quality. In addition, we explored associations between reduced FA in the right ILF and quantitative ASD characteristics, and the involvement of the right ILF in visual processing, which is known to be altered in ASD. Method: Global probabilistic tractography was performed on diffusion-weighted imaging data of 17 adolescent boys with ASD and 17 typically developing boys, matched for age, performance IQ, handedness, and data quality. Four tasks were administered to measure various aspects of visual information processing, together with questionnaires assessing ASD characteristics. Group differences were examined and the neural data were integrated with previously published findings using Bayesian statistics to quantify evidence for replication and to pool data and thus increase statistical power. (Partial) correlations were calculated to investigate associations between measures. Results: The ASD group showed consistently reduced FA only in the right ILF and slower performance on the visual search task. Bayesian statistics pooling data across studies confirmed that group differences in FA were confined to the right ILF only, with the evidence for altered FA in the left ILF being indecisive. Lower FA in the right ILF tended to covary with slower visual search and a more fragmented part-oriented processing style. Individual differences in FA of the right ILF were not reliably associated with the severity of ASD traits after controlling for clinical status. Conclusion: Our findings support the growing evidence for reduced FA along a specific fiber tract in ASD, the right ILF. En ligne : http://dx.doi.org/10.1186/s13229-018-0188-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354
in Molecular Autism > 9 (2018) . - 10p.[article] Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study [Texte imprimé et/ou numérique] / Bart BOETS, Auteur ; L. VAN EYLEN, Auteur ; K. SITEK, Auteur ; P. MOORS, Auteur ; I. NOENS, Auteur ; J. STEYAERT, Auteur ; S. SUNAERT, Auteur ; J. WAGEMANS, Auteur . - 10p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 10p.
Mots-clés : Autism spectrum disorder Diffusion-weighted imaging Inferior longitudinal fasciculus Structural connectivity Visual processing Index. décimale : PER Périodiques Résumé : Background: One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF). This study aimed at replicating the observation of reduced FA along the right ILF in ASD, while controlling for group differences in head motion and data quality. In addition, we explored associations between reduced FA in the right ILF and quantitative ASD characteristics, and the involvement of the right ILF in visual processing, which is known to be altered in ASD. Method: Global probabilistic tractography was performed on diffusion-weighted imaging data of 17 adolescent boys with ASD and 17 typically developing boys, matched for age, performance IQ, handedness, and data quality. Four tasks were administered to measure various aspects of visual information processing, together with questionnaires assessing ASD characteristics. Group differences were examined and the neural data were integrated with previously published findings using Bayesian statistics to quantify evidence for replication and to pool data and thus increase statistical power. (Partial) correlations were calculated to investigate associations between measures. Results: The ASD group showed consistently reduced FA only in the right ILF and slower performance on the visual search task. Bayesian statistics pooling data across studies confirmed that group differences in FA were confined to the right ILF only, with the evidence for altered FA in the left ILF being indecisive. Lower FA in the right ILF tended to covary with slower visual search and a more fragmented part-oriented processing style. Individual differences in FA of the right ILF were not reliably associated with the severity of ASD traits after controlling for clinical status. Conclusion: Our findings support the growing evidence for reduced FA along a specific fiber tract in ASD, the right ILF. En ligne : http://dx.doi.org/10.1186/s13229-018-0188-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 Autism as a disconnection syndrome: A qualitative and quantitative review of diffusion tensor imaging studies / Margot HOPPENBROUWERS in Research in Autism Spectrum Disorders, 8-4 (April 2014)
[article]
Titre : Autism as a disconnection syndrome: A qualitative and quantitative review of diffusion tensor imaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Margot HOPPENBROUWERS, Auteur ; Maaike VANDERMOSTEN, Auteur ; Bart BOETS, Auteur Article en page(s) : p.387-412 Mots-clés : Autism spectrum disorder Diffusion tensor imaging Review Brain connectivity Fibre tracking Index. décimale : PER Périodiques Résumé : This review aims at evaluating the leading hypothesis of lower long-range and greater short-range cortical connectivity in individuals with autism spectrum disorder (ASD) by the available literature on diffusion tensor imaging (DTI) studies. DTI, coupled with tractography, assesses the structural connections between cortical regions and quantifies their white matter integrity. First, we provide an extensive qualitative overview of DTI findings in ASD. Next, to reveal convergence between studies, results are quantitatively analyzed using Activation Likelihood Estimation (ALE) and fibre tracking is performed to visualize the white matter tracts running through the obtained ALE clusters. Finally, findings from DTI research are related to specific symptoms characteristic of ASD. Overall, the qualitative analysis yields a widespread disruption of white matter integrity in the brain of individuals with ASD as compared to typically developing controls. This is the case for both the long-range and the local short-range connections, partially contradicting the leading hypothesis. However, several studies investigating very young children with ASD report greater structural connectivity, suggesting a developmental switch in white matter integrity in the ASD brain. Based on the combined qualitative and quantitative analysis, the corpus callosum and the ventral tracts emerge as particularly affected connections in individuals with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226
in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.387-412[article] Autism as a disconnection syndrome: A qualitative and quantitative review of diffusion tensor imaging studies [Texte imprimé et/ou numérique] / Margot HOPPENBROUWERS, Auteur ; Maaike VANDERMOSTEN, Auteur ; Bart BOETS, Auteur . - p.387-412.
in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.387-412
Mots-clés : Autism spectrum disorder Diffusion tensor imaging Review Brain connectivity Fibre tracking Index. décimale : PER Périodiques Résumé : This review aims at evaluating the leading hypothesis of lower long-range and greater short-range cortical connectivity in individuals with autism spectrum disorder (ASD) by the available literature on diffusion tensor imaging (DTI) studies. DTI, coupled with tractography, assesses the structural connections between cortical regions and quantifies their white matter integrity. First, we provide an extensive qualitative overview of DTI findings in ASD. Next, to reveal convergence between studies, results are quantitatively analyzed using Activation Likelihood Estimation (ALE) and fibre tracking is performed to visualize the white matter tracts running through the obtained ALE clusters. Finally, findings from DTI research are related to specific symptoms characteristic of ASD. Overall, the qualitative analysis yields a widespread disruption of white matter integrity in the brain of individuals with ASD as compared to typically developing controls. This is the case for both the long-range and the local short-range connections, partially contradicting the leading hypothesis. However, several studies investigating very young children with ASD report greater structural connectivity, suggesting a developmental switch in white matter integrity in the ASD brain. Based on the combined qualitative and quantitative analysis, the corpus callosum and the ventral tracts emerge as particularly affected connections in individuals with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up / Sylvie BERNAERTS in Molecular Autism, 11 (2020)
[article]
Titre : Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up Type de document : Texte imprimé et/ou numérique Auteurs : Sylvie BERNAERTS, Auteur ; Bart BOETS, Auteur ; Guy BOSMANS, Auteur ; Jean STEYAERT, Auteur ; Kaat ALAERTS, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Attachment Autism spectrum disorder Oxytocin Repetitive and restricted behavior Social responsiveness Index. décimale : PER Périodiques Résumé : BACKGROUND: Intranasal administration of the "prosocial" neuropeptide oxytocin is increasingly explored as a potential treatment for targeting the core characteristics of autism spectrum disorder (ASD). However, long-term follow-up studies, evaluating the possibility of long-lasting retention effects, are currently lacking. METHODS: Using a double-blind, randomized, placebo-controlled, parallel design, this pilot clinical trial explored the possibility of long-lasting behavioral effects of 4 weeks of intranasal oxytocin treatment (24 International Units once daily in the morning) in 40 adult men with ASD. To do so, self-report and informant-based questionnaires assessing core autism symptoms and characterizations of attachment were administered at baseline, immediately after 4 weeks of treatment (approximately 24 h after the last nasal spray administration), and at two follow-up sessions, 4 weeks and 1 year post-treatment. RESULTS: No treatment-specific effects were identified in the primary outcome assessing social symptoms (Social Responsiveness Scale, self- and informant-rated). In particular, with respect to self-reported social responsiveness, improvements were evident both in the oxytocin and in the placebo group, yielding no significant between-group difference (p = .37). Also informant-rated improvements in social responsiveness were not significantly larger in the oxytocin, compared to the placebo group (between-group difference: p = .19). Among the secondary outcome measures, treatment-specific improvements were identified in the Repetitive Behavior Scale and State Adult Attachment Measure, indicating reductions in self-reported repetitive behaviors (p = .04) and reduced feelings of avoidance toward others (p = .03) in the oxytocin group compared to the placebo group, up to 1 month and even 1 year post-treatment. Treatment-specific effects were also revealed in screenings of mood states (Profile of Mood States), indicating higher reports of "vigor" (feeling energetic, active, lively) in the oxytocin, compared to the placebo group (p = .03). CONCLUSIONS: While no treatment-specific improvements were evident in terms of core social symptoms, the current observations of long-term beneficial effects on repetitive behaviors and feelings of avoidance are promising and suggestive of a therapeutic potential of oxytocin treatment for ASD. However, given the exploratory nature of this pilot study, future studies are warranted to evaluate the long-term effects of OT administration further. TRIAL REGISTRATION: The trial was registered with the European Clinical Trial Registry (Eudract 2014-000586-45) on January 22, 2014 (https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-000586-45/BE). En ligne : http://dx.doi.org/10.1186/s13229-020-0313-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 6 p.[article] Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up [Texte imprimé et/ou numérique] / Sylvie BERNAERTS, Auteur ; Bart BOETS, Auteur ; Guy BOSMANS, Auteur ; Jean STEYAERT, Auteur ; Kaat ALAERTS, Auteur . - 6 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 6 p.
Mots-clés : Attachment Autism spectrum disorder Oxytocin Repetitive and restricted behavior Social responsiveness Index. décimale : PER Périodiques Résumé : BACKGROUND: Intranasal administration of the "prosocial" neuropeptide oxytocin is increasingly explored as a potential treatment for targeting the core characteristics of autism spectrum disorder (ASD). However, long-term follow-up studies, evaluating the possibility of long-lasting retention effects, are currently lacking. METHODS: Using a double-blind, randomized, placebo-controlled, parallel design, this pilot clinical trial explored the possibility of long-lasting behavioral effects of 4 weeks of intranasal oxytocin treatment (24 International Units once daily in the morning) in 40 adult men with ASD. To do so, self-report and informant-based questionnaires assessing core autism symptoms and characterizations of attachment were administered at baseline, immediately after 4 weeks of treatment (approximately 24 h after the last nasal spray administration), and at two follow-up sessions, 4 weeks and 1 year post-treatment. RESULTS: No treatment-specific effects were identified in the primary outcome assessing social symptoms (Social Responsiveness Scale, self- and informant-rated). In particular, with respect to self-reported social responsiveness, improvements were evident both in the oxytocin and in the placebo group, yielding no significant between-group difference (p = .37). Also informant-rated improvements in social responsiveness were not significantly larger in the oxytocin, compared to the placebo group (between-group difference: p = .19). Among the secondary outcome measures, treatment-specific improvements were identified in the Repetitive Behavior Scale and State Adult Attachment Measure, indicating reductions in self-reported repetitive behaviors (p = .04) and reduced feelings of avoidance toward others (p = .03) in the oxytocin group compared to the placebo group, up to 1 month and even 1 year post-treatment. Treatment-specific effects were also revealed in screenings of mood states (Profile of Mood States), indicating higher reports of "vigor" (feeling energetic, active, lively) in the oxytocin, compared to the placebo group (p = .03). CONCLUSIONS: While no treatment-specific improvements were evident in terms of core social symptoms, the current observations of long-term beneficial effects on repetitive behaviors and feelings of avoidance are promising and suggestive of a therapeutic potential of oxytocin treatment for ASD. However, given the exploratory nature of this pilot study, future studies are warranted to evaluate the long-term effects of OT administration further. TRIAL REGISTRATION: The trial was registered with the European Clinical Trial Registry (Eudract 2014-000586-45) on January 22, 2014 (https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-000586-45/BE). En ligne : http://dx.doi.org/10.1186/s13229-020-0313-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? A randomized controlled trial / Matthijs MOERKERKE in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)
[article]
Titre : Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? A randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Matthijs MOERKERKE, Auteur ; Nicky DANIELS, Auteur ; Stephanie VAN DER DONCK, Auteur ; Laura TIBERMONT, Auteur ; Tiffany TANG, Auteur ; Edward DEBBAUT, Auteur ; Annelies BAMPS, Auteur ; Jellina PRINSEN, Auteur ; Jean STEYAERT, Auteur ; Kaat ALAERTS, Auteur ; Bart BOETS, Auteur Article en page(s) : p.1583-1595 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and interaction. Crucial for efficient social interaction is the ability to quickly and accurately extract information from a person's face. Frequency-tagging electroencephalography (EEG) is a novel tool to quantify face-processing sensitivity in a robust and implicit manner. In terms of intervention approaches, intranasal administration of oxytocin (OT) is increasingly considered as a potential pharmacological approach for improving socio-communicative difficulties in ASD, through enhancing social salience and/or reducing (social) stress and anxiety. Methods In this randomized, double-blind, placebo-controlled, mechanistic pharmaco-neuroimaging clinical trial, we implemented frequency-tagging EEG to conduct an exploratory investigation into the impact of repeated OT administration (4?weeks, 12?IU, twice daily) on neural sensitivity towards happy and fearful facial expressions in children with ASD (8-12?years old; OT: n=29; placebo: n=32). Neural effects were assessed at baseline, post-nasal spray (24?hr after the last nasal spray) and at a follow-up session, 4?weeks after the OT administration period. At baseline, neural assessments of children with ASD were compared with those of an age- and gender-matched cohort of neurotypical (NT) children (n=39). Results Children with ASD demonstrated reduced neural sensitivity towards expressive faces, as compared to NT children. Upon nasal spray administration, children with ASD displayed a significant increase in neural sensitivity at the post- and follow-up sessions, but only in the placebo group, likely reflecting an implicit learning effect. Strikingly, in the OT group, neural sensitivity remained unaffected from the baseline to the post-session, likely reflecting a dampening of an otherwise typically occurring implicit learning effect. Conclusions First, we validated the robustness of the frequency-tagging EEG approach to assess reduced neural sensitivity towards expressive faces in children with ASD. Furthermore, in contrast to social salience effects observed after single-dose administrations, repeated OT administration dampened typically occurring learning effects in neural sensitivity. In line with OT's social anxiolytic account, these observations possibly reflect a predominant (social) stress regulatory effect towards emotionally evocative faces after repeated OT administration. En ligne : https://doi.org/10.1111/jcpp.13850 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512
in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1583-1595[article] Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? A randomized controlled trial [Texte imprimé et/ou numérique] / Matthijs MOERKERKE, Auteur ; Nicky DANIELS, Auteur ; Stephanie VAN DER DONCK, Auteur ; Laura TIBERMONT, Auteur ; Tiffany TANG, Auteur ; Edward DEBBAUT, Auteur ; Annelies BAMPS, Auteur ; Jellina PRINSEN, Auteur ; Jean STEYAERT, Auteur ; Kaat ALAERTS, Auteur ; Bart BOETS, Auteur . - p.1583-1595.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1583-1595
Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and interaction. Crucial for efficient social interaction is the ability to quickly and accurately extract information from a person's face. Frequency-tagging electroencephalography (EEG) is a novel tool to quantify face-processing sensitivity in a robust and implicit manner. In terms of intervention approaches, intranasal administration of oxytocin (OT) is increasingly considered as a potential pharmacological approach for improving socio-communicative difficulties in ASD, through enhancing social salience and/or reducing (social) stress and anxiety. Methods In this randomized, double-blind, placebo-controlled, mechanistic pharmaco-neuroimaging clinical trial, we implemented frequency-tagging EEG to conduct an exploratory investigation into the impact of repeated OT administration (4?weeks, 12?IU, twice daily) on neural sensitivity towards happy and fearful facial expressions in children with ASD (8-12?years old; OT: n=29; placebo: n=32). Neural effects were assessed at baseline, post-nasal spray (24?hr after the last nasal spray) and at a follow-up session, 4?weeks after the OT administration period. At baseline, neural assessments of children with ASD were compared with those of an age- and gender-matched cohort of neurotypical (NT) children (n=39). Results Children with ASD demonstrated reduced neural sensitivity towards expressive faces, as compared to NT children. Upon nasal spray administration, children with ASD displayed a significant increase in neural sensitivity at the post- and follow-up sessions, but only in the placebo group, likely reflecting an implicit learning effect. Strikingly, in the OT group, neural sensitivity remained unaffected from the baseline to the post-session, likely reflecting a dampening of an otherwise typically occurring implicit learning effect. Conclusions First, we validated the robustness of the frequency-tagging EEG approach to assess reduced neural sensitivity towards expressive faces in children with ASD. Furthermore, in contrast to social salience effects observed after single-dose administrations, repeated OT administration dampened typically occurring learning effects in neural sensitivity. In line with OT's social anxiolytic account, these observations possibly reflect a predominant (social) stress regulatory effect towards emotionally evocative faces after repeated OT administration. En ligne : https://doi.org/10.1111/jcpp.13850 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 Cognitive flexibility in autism spectrum disorder: Explaining the inconsistencies? / Lien VAN EYLEN in Research in Autism Spectrum Disorders, 5-4 (October-December 2011)
[article]
Titre : Cognitive flexibility in autism spectrum disorder: Explaining the inconsistencies? Type de document : Texte imprimé et/ou numérique Auteurs : Lien VAN EYLEN, Auteur ; Bart BOETS, Auteur ; Jean STEYAERT, Auteur ; Kris EVERS, Auteur ; Johan WAGEMANS, Auteur ; Ilse L.J. NOENS, Auteur Année de publication : 2011 Article en page(s) : p.1390-1401 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Cognitive flexibility Task-switching Wisconsin Card Sorting Task Disengagement Task instructions Index. décimale : PER Périodiques Résumé : The Wisconsin Card Sorting Task (WCST) is the only cognitive flexibility task that has consistently shown deficits in individuals with an autism spectrum disorder (ASD). As this is the only task characterized by limited explicit task instructions and a high degree of disengagement required to perform the switch, we hypothesized that cognitive flexibility deficits of individuals with ASD might only become apparent in situations fulfilling these requirements. However, the WCST involves various additional cognitive processes besides switching, making it uncertain whether difficulties are indeed due to cognitive flexibility impairments. The aim of this study was to investigate whether individuals with ASD show cognitive flexibility impairments on a more controlled task-switching variant of the WCST, still fulfilling both requirements. We therefore developed such a task and administered it to 40 high-functioning children with ASD and 40 age- and IQ- matched typically developing controls. As predicted, individuals with ASD made more perseveration errors and had a significantly higher switch cost than typically developing controls, but they performed equally well on the control measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.01.025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125
in Research in Autism Spectrum Disorders > 5-4 (October-December 2011) . - p.1390-1401[article] Cognitive flexibility in autism spectrum disorder: Explaining the inconsistencies? [Texte imprimé et/ou numérique] / Lien VAN EYLEN, Auteur ; Bart BOETS, Auteur ; Jean STEYAERT, Auteur ; Kris EVERS, Auteur ; Johan WAGEMANS, Auteur ; Ilse L.J. NOENS, Auteur . - 2011 . - p.1390-1401.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 5-4 (October-December 2011) . - p.1390-1401
Mots-clés : Autism spectrum disorders Cognitive flexibility Task-switching Wisconsin Card Sorting Task Disengagement Task instructions Index. décimale : PER Périodiques Résumé : The Wisconsin Card Sorting Task (WCST) is the only cognitive flexibility task that has consistently shown deficits in individuals with an autism spectrum disorder (ASD). As this is the only task characterized by limited explicit task instructions and a high degree of disengagement required to perform the switch, we hypothesized that cognitive flexibility deficits of individuals with ASD might only become apparent in situations fulfilling these requirements. However, the WCST involves various additional cognitive processes besides switching, making it uncertain whether difficulties are indeed due to cognitive flexibility impairments. The aim of this study was to investigate whether individuals with ASD show cognitive flexibility impairments on a more controlled task-switching variant of the WCST, still fulfilling both requirements. We therefore developed such a task and administered it to 40 high-functioning children with ASD and 40 age- and IQ- matched typically developing controls. As predicted, individuals with ASD made more perseveration errors and had a significantly higher switch cost than typically developing controls, but they performed equally well on the control measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.01.025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 Combined frequency-tagging EEG and eye-tracking measures provide no support for the "excess mouth/diminished eye attention" hypothesis in autism / Sofie VETTORI in Molecular Autism, 11 (2020)
PermalinkCorrigendum to “Cognitive flexibility in autism spectrum disorder: Explaining the inconsistencies?” [Res. Autism Spectr. Disord. 5 (2011) 1390–1401] / Lien VAN EYLEN in Research in Autism Spectrum Disorders, 23 (March 2016)
PermalinkEffects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial / Matthijs MOERKERKE ; Jean STEYAERT ; Annelies BAMPS ; Edward DEBBAUT ; Jellina PRINSEN ; Tiffany TANG ; Stephanie VAN DER DONCK ; Bart BOETS ; Kaat ALAERTS in Molecular Autism, 14 (2023)
PermalinkExecutive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? / Lien VAN EYLEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)
PermalinkFast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism / S. VAN DER DONCK in Journal of Autism and Developmental Disorders, 49-11 (November 2019)
PermalinkFragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay / Bart BOETS in Journal of Autism and Developmental Disorders, 45-6 (June 2015)
PermalinkIntact neural representations of affective meaning of touch but lack of embodied resonance in autism: a multi-voxel pattern analysis study / H. LEE MASSON in Molecular Autism, 10 (2019)
PermalinkInvestigating automatic emotion processing in boys with autism via eye tracking and facial mimicry recordings / S. VAN DER DONCK in Autism Research, 14-7 (July 2021)
PermalinkLocal and Global Visual Processing in Autism Spectrum Disorders: Influence of Task and Sample Characteristics and Relation to Symptom Severity / L. VAN EYLEN in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
PermalinkNeural sensitivity to facial identity and facial expression discrimination in adults with autism / Michelle HENDRIKS ; Silke VOS ; Hans OP DE BEECK ; Bart BOETS in Autism Research, 16-11 (November 2023)
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