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Détail de l'auteur
Auteur Malcolm HOOPER |
Documents disponibles écrits par cet auteur (1)
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How Could a Gluten- and Casein-Free Diet Ameliorate Symptoms Associated with Autism Spectrum Conditions? / Paul WHITELEY in Autism Insights, 2 ([01/01/2010])
[article]
Titre : How Could a Gluten- and Casein-Free Diet Ameliorate Symptoms Associated with Autism Spectrum Conditions? Type de document : Application, site Internet Auteurs : Paul WHITELEY, Auteur ; Paul SHATTOCK, Auteur ; Kevin CARR, Auteur ; Malcolm HOOPER, Auteur ; Lynda TODD, Auteur Année de publication : 2010 Article en page(s) : p.39-53 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There is a considerable body of experimental evidence suggesting potential efficacy of a diet devoid of gluten and casein in ameliorating some of the core and peripheral symptoms of autism spectrum conditions. Although phenotypic details of best- and non-responders to dietary change remain under investigation, the range of biological mechanisms implicated during intervention is growing. The question of how diet works remains unanswered. We discuss three prospective modes of action used alone and in combination to explain the effects of a gluten- and casein-free diet on autism spectrum conditions focussed on direct or co-morbid consequences of: i) gluten sensitive enteropathy or coeliac disease, ii) food allergy and/or atopic disease, and iii) underlying hyperpermeability of the gastrointestinal tract (leaky gut) and subsequent passage of biologically-active peptide and related species into the central nervous system. No single theory offers a universal explanation for the biological basis of dietary effectiveness despite individual associations with various cases of autism. Impaired intestinal barrier function is a common denominator and represents a promising area for investigation. Furthermore, a number of key points derived from each model offer testable markers for experimental evaluation onwards to ascertaining potential responsiveness to such dietary intervention in autism. En ligne : http://dx.doi.org/10.4137/AUI.S6275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118
in Autism Insights > 2 [01/01/2010] . - p.39-53[article] How Could a Gluten- and Casein-Free Diet Ameliorate Symptoms Associated with Autism Spectrum Conditions? [Application, site Internet] / Paul WHITELEY, Auteur ; Paul SHATTOCK, Auteur ; Kevin CARR, Auteur ; Malcolm HOOPER, Auteur ; Lynda TODD, Auteur . - 2010 . - p.39-53.
Langues : Anglais (eng)
in Autism Insights > 2 [01/01/2010] . - p.39-53
Index. décimale : PER Périodiques Résumé : There is a considerable body of experimental evidence suggesting potential efficacy of a diet devoid of gluten and casein in ameliorating some of the core and peripheral symptoms of autism spectrum conditions. Although phenotypic details of best- and non-responders to dietary change remain under investigation, the range of biological mechanisms implicated during intervention is growing. The question of how diet works remains unanswered. We discuss three prospective modes of action used alone and in combination to explain the effects of a gluten- and casein-free diet on autism spectrum conditions focussed on direct or co-morbid consequences of: i) gluten sensitive enteropathy or coeliac disease, ii) food allergy and/or atopic disease, and iii) underlying hyperpermeability of the gastrointestinal tract (leaky gut) and subsequent passage of biologically-active peptide and related species into the central nervous system. No single theory offers a universal explanation for the biological basis of dietary effectiveness despite individual associations with various cases of autism. Impaired intestinal barrier function is a common denominator and represents a promising area for investigation. Furthermore, a number of key points derived from each model offer testable markers for experimental evaluation onwards to ascertaining potential responsiveness to such dietary intervention in autism. En ligne : http://dx.doi.org/10.4137/AUI.S6275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118