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Auteur Jay BELSKY |
Documents disponibles écrits par cet auteur (42)
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Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model / Alexia JOLICOEUR-MARTINEAU in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model Type de document : Texte imprimé et/ou numérique Auteurs : Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M. T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur Article en page(s) : p.73-83 Langues : Anglais (eng) Mots-clés : diathesis-stress differential-susceptibility gene-by-environment interaction regions of significance vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.73-83[article] Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model [Texte imprimé et/ou numérique] / Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M. T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur . - p.73-83.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.73-83
Mots-clés : diathesis-stress differential-susceptibility gene-by-environment interaction regions of significance vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects / Maartje P.C.M. LUIJK in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)
[article]
Titre : Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects Type de document : Texte imprimé et/ou numérique Auteurs : Maartje P.C.M. LUIJK, Auteur ; Glenn I. ROISMAN, Auteur ; John D. HALTIGAN, Auteur ; Henning TIEMEIER, Auteur ; Cathryn BOOTH-LAFORCE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Jay BELSKY, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Anne THARNER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Année de publication : 2011 Article en page(s) : p.1295-1307 Langues : Anglais (eng) Mots-clés : Attachment Strange Situation Procedure candidate genes parenting sensitivity G × E Index. décimale : PER Périodiques Résumé : Background and methods: In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (DRD4, DRD2, COMT, 5-HTT, OXTR) on attachment security and disorganization. Parenting was assessed using observational rating scales for parental sensitivity (Ainsworth, Bell, & Stayton, 1974), and infant attachment was assessed with the Strange Situation Procedure.
Results: We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met, consistent across both samples. Children with the Val/Met genotype showed higher disorganization scores (combined effect size d = .22, CI = .10–.34, p < .001). Gene-by-environment interaction effects were not replicable across the two samples.
Conclusions: This unexpected finding might be explained by a broader range of plasticity in heterozygotes, which may increase susceptibility to environmental influences or to dysregulation of emotional arousal. This study is unique in combining the two largest attachment cohorts with molecular genetic and observed rearing environment data to date.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02440.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1295-1307[article] Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects [Texte imprimé et/ou numérique] / Maartje P.C.M. LUIJK, Auteur ; Glenn I. ROISMAN, Auteur ; John D. HALTIGAN, Auteur ; Henning TIEMEIER, Auteur ; Cathryn BOOTH-LAFORCE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Jay BELSKY, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Anne THARNER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - 2011 . - p.1295-1307.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1295-1307
Mots-clés : Attachment Strange Situation Procedure candidate genes parenting sensitivity G × E Index. décimale : PER Périodiques Résumé : Background and methods: In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (DRD4, DRD2, COMT, 5-HTT, OXTR) on attachment security and disorganization. Parenting was assessed using observational rating scales for parental sensitivity (Ainsworth, Bell, & Stayton, 1974), and infant attachment was assessed with the Strange Situation Procedure.
Results: We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met, consistent across both samples. Children with the Val/Met genotype showed higher disorganization scores (combined effect size d = .22, CI = .10–.34, p < .001). Gene-by-environment interaction effects were not replicable across the two samples.
Conclusions: This unexpected finding might be explained by a broader range of plasticity in heterozygotes, which may increase susceptibility to environmental influences or to dysregulation of emotional arousal. This study is unique in combining the two largest attachment cohorts with molecular genetic and observed rearing environment data to date.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02440.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 Editorial Perspective: Integrating exploratory and competitive–confirmatory approaches to testing person × environment interactions / Jay BELSKY in Journal of Child Psychology and Psychiatry, 59-3 (March 2018)
[article]
Titre : Editorial Perspective: Integrating exploratory and competitive–confirmatory approaches to testing person × environment interactions Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Keith WIDAMAN, Auteur Article en page(s) : p.296-298 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Students of child development and of psychopathology have long been interested in how person characteristics (e.g. genotype, temperament) might moderate the effect of environmental exposures (e.g. harsh parenting, negative life events) on development. Historically, most such research on person × environment interaction has been guided by diathesis?stress thinking, which stipulates that some individuals, due to their personal characteristics, are more susceptible to the adverse effects of contextual risk than are others (but do not function differently under supportive or even benign conditions). En ligne : https://doi.org/10.1111/jcpp.12824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339
in Journal of Child Psychology and Psychiatry > 59-3 (March 2018) . - p.296-298[article] Editorial Perspective: Integrating exploratory and competitive–confirmatory approaches to testing person × environment interactions [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Keith WIDAMAN, Auteur . - p.296-298.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-3 (March 2018) . - p.296-298
Index. décimale : PER Périodiques Résumé : Students of child development and of psychopathology have long been interested in how person characteristics (e.g. genotype, temperament) might moderate the effect of environmental exposures (e.g. harsh parenting, negative life events) on development. Historically, most such research on person × environment interaction has been guided by diathesis?stress thinking, which stipulates that some individuals, due to their personal characteristics, are more susceptible to the adverse effects of contextual risk than are others (but do not function differently under supportive or even benign conditions). En ligne : https://doi.org/10.1111/jcpp.12824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 Effects of divorce on Dutch boys' and girls' externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Dutch Tracking Adolescents' Individual Lives Survey study? / Esther NEDERHOF in Development and Psychopathology, 24-3 (August 2012)
[article]
Titre : Effects of divorce on Dutch boys' and girls' externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Dutch Tracking Adolescents' Individual Lives Survey study? Type de document : Texte imprimé et/ou numérique Auteurs : Esther NEDERHOF, Auteur ; Jay BELSKY, Auteur ; Johan ORMEL, Auteur ; Albertine J. OLDEHINKEL, Auteur Année de publication : 2012 Article en page(s) : p.929-39 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The effects of divorce on children's behavioral development have proven to be quite varied across studies, and most developmental and family scholars today appreciate the great heterogeneity in divorce effects. Thus, this inquiry sought to determine whether select dopaminergic genes previously associated with externalizing behavior and/or found to moderate diverse environmental effects (dopamine receptors D2 and D4, catechol-O-methyltransferase) might moderate divorce effects on adolescent self-reported externalizing problems; and, if so, whether evidence of gene–environment (G × E) interaction would prove consistent with diathesis–stress or differential-susceptibility models of environmental action. Data from the first and third wave of the Dutch Tracking Adolescents' Individual Lives Survey (n = 1,134) revealed some evidence of G × E interaction reflecting diathesis–stress but not differential susceptibility. It is intriguing that some evidence pointed to “vantage sensitivity,” which are benefits accruing to those with a specific genotype when their parents remained together, the exact opposite of diathesis–stress. The limits of this work are considered, especially with regard to the conditions for testing differential susceptibility, and future directions are outlined. En ligne : http://dx.doi.org/10.1017/S0954579412000454 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178
in Development and Psychopathology > 24-3 (August 2012) . - p.929-39[article] Effects of divorce on Dutch boys' and girls' externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Dutch Tracking Adolescents' Individual Lives Survey study? [Texte imprimé et/ou numérique] / Esther NEDERHOF, Auteur ; Jay BELSKY, Auteur ; Johan ORMEL, Auteur ; Albertine J. OLDEHINKEL, Auteur . - 2012 . - p.929-39.
Langues : Anglais (eng)
in Development and Psychopathology > 24-3 (August 2012) . - p.929-39
Index. décimale : PER Périodiques Résumé : The effects of divorce on children's behavioral development have proven to be quite varied across studies, and most developmental and family scholars today appreciate the great heterogeneity in divorce effects. Thus, this inquiry sought to determine whether select dopaminergic genes previously associated with externalizing behavior and/or found to moderate diverse environmental effects (dopamine receptors D2 and D4, catechol-O-methyltransferase) might moderate divorce effects on adolescent self-reported externalizing problems; and, if so, whether evidence of gene–environment (G × E) interaction would prove consistent with diathesis–stress or differential-susceptibility models of environmental action. Data from the first and third wave of the Dutch Tracking Adolescents' Individual Lives Survey (n = 1,134) revealed some evidence of G × E interaction reflecting diathesis–stress but not differential susceptibility. It is intriguing that some evidence pointed to “vantage sensitivity,” which are benefits accruing to those with a specific genotype when their parents remained together, the exact opposite of diathesis–stress. The limits of this work are considered, especially with regard to the conditions for testing differential susceptibility, and future directions are outlined. En ligne : http://dx.doi.org/10.1017/S0954579412000454 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 Effects of divorce on Dutch boys’ and girls’ externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Tracking Adolescents’ Individual Lives Survey study?—CORRIGENDUM / Esther NEDERHOF in Development and Psychopathology, 26-2 (May 2014)
[article]
Titre : Effects of divorce on Dutch boys’ and girls’ externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Tracking Adolescents’ Individual Lives Survey study?—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Esther NEDERHOF, Auteur ; Jay BELSKY, Auteur ; Johan ORMEL, Auteur ; Albertine J. OLDEHINKEL, Auteur Article en page(s) : p.555-555 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230
in Development and Psychopathology > 26-2 (May 2014) . - p.555-555[article] Effects of divorce on Dutch boys’ and girls’ externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Tracking Adolescents’ Individual Lives Survey study?—CORRIGENDUM [Texte imprimé et/ou numérique] / Esther NEDERHOF, Auteur ; Jay BELSKY, Auteur ; Johan ORMEL, Auteur ; Albertine J. OLDEHINKEL, Auteur . - p.555-555.
in Development and Psychopathology > 26-2 (May 2014) . - p.555-555
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 Effects of maternal sensitivity on low birth weight children's academic achievement: a test of differential susceptibility versus diathesis stress / Julia JAEKEL in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)
PermalinkEnvironmental harshness and unpredictability: Do they affect the same parents and children? / Xiaoya ZHANG in Development and Psychopathology, 34-2 (May 2022)
PermalinkExternal-environmental and internal-health early life predictors of adolescent development / Sarah HARTMAN in Development and Psychopathology, 29-5 (December 2017)
PermalinkGenetic moderation of effects of maternal sensitivity on girl's age of menarche: Replication of the Manuck et al. study / Sarah HARTMAN in Development and Psychopathology, 27-3 (August 2015)
PermalinkHomotypic and heterotypic continuity of symptoms of psychiatric disorders from age 4 to 10 years: a dynamic panel model / Lars WICHSTRØM in Journal of Child Psychology and Psychiatry, 58-11 (November 2017)
PermalinkIndirect effects, via parental factors, of income harshness and unpredictability on kindergarteners? socioemotional functioning / Zhi LI in Development and Psychopathology, 34-2 (May 2022)
PermalinkInfant–mother attachment and the growth of externalizing problems across the primary-school years / Richard M. PASCO FEARON in Journal of Child Psychology and Psychiatry, 52-7 (July 2011)
PermalinkInfant temperament, early-childhood parenting, and early-adolescent development: Testing alternative models of Parenting x Temperament interaction / Xiaoya ZHANG in Development and Psychopathology, 34-3 (August 2022)
PermalinkInteractive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood / Sara R. JAFFEE in Journal of Child Psychology and Psychiatry, 56-2 (February 2015)
PermalinkNeural correlates of face familiarity in institutionalised children and links to attachment disordered behaviour / Paula S. OLIVEIRA in Journal of Child Psychology and Psychiatry, 64-5 (May 2023)
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