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Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model / Alexia JOLICOEUR-MARTINEAU in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model Type de document : Texte imprimé et/ou numérique Auteurs : Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M. T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur Article en page(s) : p.73-83 Langues : Anglais (eng) Mots-clés : diathesis-stress differential-susceptibility gene-by-environment interaction regions of significance vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.73-83[article] Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model [Texte imprimé et/ou numérique] / Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M. T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur . - p.73-83.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.73-83
Mots-clés : diathesis-stress differential-susceptibility gene-by-environment interaction regions of significance vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Parenting x Brain Development interactions as predictors of adolescent depressive symptoms and well-being: Differential susceptibility or diathesis-stress? / Camille DEANE in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : Parenting x Brain Development interactions as predictors of adolescent depressive symptoms and well-being: Differential susceptibility or diathesis-stress? Type de document : Texte imprimé et/ou numérique Auteurs : Camille DEANE, Auteur ; Nandita VIJAYAKUMAR, Auteur ; Nicholas B. ALLEN, Auteur ; Orli SCHWARTZ, Auteur ; Julian G. SIMMONS, Auteur ; Chad A. BOUSMAN, Auteur ; Christos PANTELIS, Auteur ; Sarah WHITTLE, Auteur Article en page(s) : p.139-150 Langues : Anglais (eng) Mots-clés : brain development depression diathesis-stress differential susceptibility well-being Index. décimale : PER Périodiques Résumé : It is unclear how individual differences in parenting and brain development interact to influence adolescent mental health outcomes. This study examined interactions between structural brain development and observed maternal parenting behavior in the prediction of adolescent depressive symptoms and psychological well-being. Whether findings supported diathesis-stress or differential susceptibility frameworks was tested. Participants completed observed interactions with their mothers during early adolescence (age 13), and the frequency of positive and aggressive maternal behavior were coded. Adolescents also completed structural magnetic resonance imaging scans at three time points: mean ages 13, 17, and 19. Regression models analyzed interactions between maternal behavior and longitudinal brain development in the prediction of late adolescent (age 19) outcomes. Indices designed to distinguish between diathesis-stress and differential susceptibility effects were employed. Results supported differential susceptibility: less thinning of frontal regions was associated with higher well-being in the context of low levels of aggressive maternal behavior, and lower well-being in the context of high levels of aggressive maternal behavior. Findings suggest that reduced frontal cortical thinning during adolescence may underlie increased sensitivity to maternal aggressive behavior for better and worse and highlight the importance of investigating biological vulnerability versus susceptibility. En ligne : http://dx.doi.org/10.1017/s0954579418001475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.139-150[article] Parenting x Brain Development interactions as predictors of adolescent depressive symptoms and well-being: Differential susceptibility or diathesis-stress? [Texte imprimé et/ou numérique] / Camille DEANE, Auteur ; Nandita VIJAYAKUMAR, Auteur ; Nicholas B. ALLEN, Auteur ; Orli SCHWARTZ, Auteur ; Julian G. SIMMONS, Auteur ; Chad A. BOUSMAN, Auteur ; Christos PANTELIS, Auteur ; Sarah WHITTLE, Auteur . - p.139-150.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.139-150
Mots-clés : brain development depression diathesis-stress differential susceptibility well-being Index. décimale : PER Périodiques Résumé : It is unclear how individual differences in parenting and brain development interact to influence adolescent mental health outcomes. This study examined interactions between structural brain development and observed maternal parenting behavior in the prediction of adolescent depressive symptoms and psychological well-being. Whether findings supported diathesis-stress or differential susceptibility frameworks was tested. Participants completed observed interactions with their mothers during early adolescence (age 13), and the frequency of positive and aggressive maternal behavior were coded. Adolescents also completed structural magnetic resonance imaging scans at three time points: mean ages 13, 17, and 19. Regression models analyzed interactions between maternal behavior and longitudinal brain development in the prediction of late adolescent (age 19) outcomes. Indices designed to distinguish between diathesis-stress and differential susceptibility effects were employed. Results supported differential susceptibility: less thinning of frontal regions was associated with higher well-being in the context of low levels of aggressive maternal behavior, and lower well-being in the context of high levels of aggressive maternal behavior. Findings suggest that reduced frontal cortical thinning during adolescence may underlie increased sensitivity to maternal aggressive behavior for better and worse and highlight the importance of investigating biological vulnerability versus susceptibility. En ligne : http://dx.doi.org/10.1017/s0954579418001475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses / Jay BELSKY in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)
[article]
Titre : Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur Article en page(s) : p.1135-1143 Langues : Anglais (eng) Mots-clés : Gene-environment interaction diathesis-stress differential susceptibility child care DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143[article] Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur . - p.1135-1143.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143
Mots-clés : Gene-environment interaction diathesis-stress differential susceptibility child care DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder / Jenni ROSENBERG in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)
[article]
Titre : Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jenni ROSENBERG, Auteur ; Bruce F. PENNINGTON, Auteur ; Erik G. WILLCUTT, Auteur ; Richard K. OLSON, Auteur Année de publication : 2012 Article en page(s) : p.243-251 Langues : Anglais (eng) Mots-clés : Gene environment interactions reading disability attention deficit/hyperactivity disorder bioecological diathesis-stress Index. décimale : PER Périodiques Résumé : Background: Reading disability (RD) and attention deficit/hyperactivity disorder (ADHD) are comorbid and genetically correlated, especially the inattentive dimension of ADHD (ADHD-I). However, previous research indicates that RD and ADHD enter into opposite gene by environment (G × E) interactions. Methods: This study used behavioral genetic methods to replicate these opposite G × E interactions in a sample of same-sex monozygotic and dizygotic twin pairs from the Colorado Learning Disabilities Research Center (CLDRC; DeFries et al., 1997) and to test a genetic hypothesis for why these opposite interactions occur. Results: We replicated opposite G × E interactions for RD (bioecological) and ADHD-I (diathesis-stress) with parental education in the same sample of participants. The genetic hypothesis for this opposite pattern of interactions is that only genes specific to each disorder enter into these opposite interactions, not the shared genes underlying their comorbidity. To test this hypothesis, we used single models with an exploratory three-way interaction, in which the G × E interactions for each disorder were moderated by comorbidity. Neither three-way interaction was significant. The heritability of RD did not vary as a function of parental education and ADHD-I. Similarly, the heritability of ADHD-I did not vary as a function of parental education and RD. Conclusions: We documented opposite G × E interactions in RD and ADHD-I in the same overall twin sample, but the explanation for this apparent paradox remains unclear. Examining specific genes and more specific environmental factors may help resolve the paradox. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02452.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.243-251[article] Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Jenni ROSENBERG, Auteur ; Bruce F. PENNINGTON, Auteur ; Erik G. WILLCUTT, Auteur ; Richard K. OLSON, Auteur . - 2012 . - p.243-251.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.243-251
Mots-clés : Gene environment interactions reading disability attention deficit/hyperactivity disorder bioecological diathesis-stress Index. décimale : PER Périodiques Résumé : Background: Reading disability (RD) and attention deficit/hyperactivity disorder (ADHD) are comorbid and genetically correlated, especially the inattentive dimension of ADHD (ADHD-I). However, previous research indicates that RD and ADHD enter into opposite gene by environment (G × E) interactions. Methods: This study used behavioral genetic methods to replicate these opposite G × E interactions in a sample of same-sex monozygotic and dizygotic twin pairs from the Colorado Learning Disabilities Research Center (CLDRC; DeFries et al., 1997) and to test a genetic hypothesis for why these opposite interactions occur. Results: We replicated opposite G × E interactions for RD (bioecological) and ADHD-I (diathesis-stress) with parental education in the same sample of participants. The genetic hypothesis for this opposite pattern of interactions is that only genes specific to each disorder enter into these opposite interactions, not the shared genes underlying their comorbidity. To test this hypothesis, we used single models with an exploratory three-way interaction, in which the G × E interactions for each disorder were moderated by comorbidity. Neither three-way interaction was significant. The heritability of RD did not vary as a function of parental education and ADHD-I. Similarly, the heritability of ADHD-I did not vary as a function of parental education and RD. Conclusions: We documented opposite G × E interactions in RD and ADHD-I in the same overall twin sample, but the explanation for this apparent paradox remains unclear. Examining specific genes and more specific environmental factors may help resolve the paradox. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02452.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 Infant temperament, early-childhood parenting, and early-adolescent development: Testing alternative models of Parenting x Temperament interaction / Xiaoya ZHANG in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Infant temperament, early-childhood parenting, and early-adolescent development: Testing alternative models of Parenting x Temperament interaction Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoya ZHANG, Auteur ; Kristina SAYLER, Auteur ; Sarah HARTMAN, Auteur ; Jay BELSKY, Auteur Année de publication : 2022 Article en page(s) : p.784-795 Langues : Anglais (eng) Mots-clés : temperament-X-parenting interaction differential-susceptibility diathesis-stress re-parameterized model comparison ALSPAC Index. décimale : PER Périodiques Résumé : Here we evaluate whether infant difficult temperament (6 months) functions as a vulnerability or more general plasticity factor when investigating effects of early-childhood parenting (8 “42 months) on both positive and negative early-adolescent socioemotional development (age 8 “11 years). Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 14,541) and a re-parameterized model-testing approach to distinguish alternative person × environment conceptual models, results indicated that temperament × parenting interacted in predicting externalizing (i.e., hyperactivity, conduct problems), but not other behavior (i.e., emotional symptoms, peer problems), in a (weak) differential susceptibility manner. While more and less supportive parenting predicted, respectively, fewer and more behavior problems, it did so more strongly for children who were more difficult as infants. En ligne : http://dx.doi.org/10.1017/S0954579420002096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Development and Psychopathology > 34-3 (August 2022) . - p.784-795[article] Infant temperament, early-childhood parenting, and early-adolescent development: Testing alternative models of Parenting x Temperament interaction [Texte imprimé et/ou numérique] / Xiaoya ZHANG, Auteur ; Kristina SAYLER, Auteur ; Sarah HARTMAN, Auteur ; Jay BELSKY, Auteur . - 2022 . - p.784-795.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.784-795
Mots-clés : temperament-X-parenting interaction differential-susceptibility diathesis-stress re-parameterized model comparison ALSPAC Index. décimale : PER Périodiques Résumé : Here we evaluate whether infant difficult temperament (6 months) functions as a vulnerability or more general plasticity factor when investigating effects of early-childhood parenting (8 “42 months) on both positive and negative early-adolescent socioemotional development (age 8 “11 years). Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 14,541) and a re-parameterized model-testing approach to distinguish alternative person × environment conceptual models, results indicated that temperament × parenting interacted in predicting externalizing (i.e., hyperactivity, conduct problems), but not other behavior (i.e., emotional symptoms, peer problems), in a (weak) differential susceptibility manner. While more and less supportive parenting predicted, respectively, fewer and more behavior problems, it did so more strongly for children who were more difficult as infants. En ligne : http://dx.doi.org/10.1017/S0954579420002096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484